TY  - JOUR
A1  - Bender, Oliver
A1  - Roth, Charlotte E.
A1  - Job, Hubert
T1  - Protected areas and population development in the alps
JF  - eco.mont : Journal on Protected Mountain Areas Research and Management
N2  - Nearly a quarter of the Alpine area is covered by a dense network of large protected areas (LPAs) of the four categories national park(NP), biosphere reserve (BR), nature park and world natural heritage site (WNHS). From the time of early industrialization, the Alpine area has undergone a mixed and increasingly polarized demographic development between the poles of immigration and emigration. This article investigates the possible mutual impact of population development and the existence of LPAs. The research design includes a quantitative survey of all Alpine LPAs in terms of their population development and the structure of immigration in the first decade of the 21st century. This will be linked with qualitative expert interviews in four selected NPs. The overall results allow an interpretation of the statistical
correlations between type of LPA and migration.
KW  - geography
KW  - amenity migration
KW  - national parks
KW  - population
KW  - protected areas
KW  - regional development
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-181901
VL  - 9
IS  - Special issue
ER  - 
TY  - JOUR
A1  - Wille, Michael
A1  - Schümann, Antje
A1  - Kreutzer, Michael
A1  - Glocker, Michael O
A1  - Wree, Andreas
A1  - Mutzbauer, Grit
A1  - Schmitt, Oliver
T1  - The proteome profiles of the olfactory bulb of juvenile, adult and aged rats - an ontogenetic study
JF  - Proteome Science
N2  - Background: 
In this study, we searched for proteins that change their expression in the olfactory bulb (oB) of rats during ontogenesis. Up to now, protein expression differences in the developing animal are not fully understood. Our investigation focused on the question whether specific proteins exist which are only expressed during different development stages. This might lead to a better characterization of the microenvironment and to a better determination of factors and candidates that influence the differentiation of neuronal progenitor cells. 

Results: 
After analyzing the samples by two-dimensional polyacrylamide gel electrophoresis (2DE) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS), it could be shown that the number of expressed proteins differs depending on the developmental stages. Especially members of the functional classes, like proteins of biosynthesis, regulatory proteins and structural proteins, show the highest differential expression in the stages of development analyzed. 

Conclusion: 
In this study, quantitative changes in the expression of proteins in the oB at different developmental stages (postnatal days (P) 7, 90 and 637) could be observed. Furthermore, the expression of many proteins was found at specific developmental stages. It was possible to identify these proteins which are involved in processes like support of cell migration and differentiation.
KW  - axonally transported proteins
KW  - hippocampal stem cells
KW  - cerebral cortex
KW  - regional development
KW  - development
KW  - brain
KW  - olfactory bulb
KW  - proteomics
KW  - rat
KW  - growth-associated protein
KW  - messenger-RNA transport
KW  - goldfish optic nerve
KW  - postnatal development
KW  - subventricular zone
KW  - neuronal differentiation
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-144073
VL  - 13
IS  - 8
ER  -