TY  - JOUR
A1  - Wiegering, V.
A1  - Schlegel, P. G.
A1  - Winkler, B.
A1  - Lazarus, M.
A1  - Wirth, C.
A1  - Ernestus, K.
A1  - Walles, T.
A1  - Liese, J.
T1  - Persisting Cough as the Single Presenting Symptom of an Intrathoracic Tumor in a Nine-Month-Old Child with Adenovirus Airway Infection
JF  - Journal of Case Reports and Studies
N2  - We report on a nine-month-old girl who presented with persisting cough, and diminished ventilation of the left hemithorax. Viral pneumonia was suspected after Adenovirus detection by PCR, but chest X-rays showed a persistent shadowing of the left hemithorax and persistent coughing despite clinical improvement. Because of the discrepancy between clinical and radiological signs further investigations by ultrasound and CT scan were performed, which visualized an intrathroracic tumor. Histopathology confirmed diagnosis of a teratoma.

This case highlights the need for careful evaluation by the treating physicians. If the chest X-ray provides a discrepancy to the clinical findings or persistent pathologies exist, differential diagnosis should be discussed and further diagnostics be performed.
KW  - tumor
KW  - children
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-125536
VL  - 3
IS  - 2
ER  - 
TY  - JOUR
A1  - Sagiv, Jitka Y.
A1  - Michaeli, Janna
A1  - Assi, Simaan
A1  - Mishalian, Inbal
A1  - Kisos, Hen
A1  - Levy, Liran
A1  - Damti, Pazzit
A1  - Lumbroso, Delphine
A1  - Polyansky, Lola
A1  - Sionov, Ronit V.
A1  - Ariel, Amiram
A1  - Hovav, Avi-Hai
A1  - Henke, Erik
A1  - Fridlender, Zvi G.
A1  - Granot, Zvi
T1  - Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer
JF  - Cell Reports
N2  - Controversy surrounds neutrophil function in cancer because neutrophils were shown to provide both pro-and antitumor functions. We identified a heterogeneous subset of low-density neutrophils (LDNs) that appear transiently in self-resolving inflammation but accumulate continuously with cancer progression. LDNs display impaired neutrophil function and immunosuppressive properties, characteristics that are in stark contrast to those of mature, high-density neutrophils (HDNs). LDNs consist of both immature myeloid-derived suppressor cells (MDSCs) and mature cells that are derived from HDNs in a TGF-beta-dependent mechanism. Our findings identify three distinct populations of circulating neutrophils and challenge the concept that mature neutrophils have limited plasticity. Furthermore, our findings provide a mechanistic explanation to mitigate the controversy surrounding neutrophil function in cancer.
KW  - tumorigenic properties
KW  - innate immunity
KW  - adenocarcinoma
KW  - inhibition
KW  - model
KW  - suppressor cells
KW  - tumor
KW  - TGF-beta
KW  - mice
KW  - lung
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-144102
VL  - 10
IS  - 4
ER  -