TY  - JOUR
A1  - Schmitt, Andrea
A1  - Tatsch, Laura
A1  - Vollhardt, Alisa
A1  - Schneider-Axmann, Thomas
A1  - Raabe, Florian J.
A1  - Roell, Lukas
A1  - Heinsen, Helmut
A1  - Hof, Patrick R.
A1  - Falkai, Peter
A1  - Schmitz, Christoph
T1  - Decreased oligodendrocyte number in hippocampal subfield CA4 in schizophrenia: a replication study
JF  - Cells
N2  - Hippocampus-related cognitive deficits in working and verbal memory are frequent in schizophrenia, and hippocampal volume loss, particularly in the cornu ammonis (CA) subregions, was shown by magnetic resonance imaging studies. However, the underlying cellular alterations remain elusive. By using unbiased design-based stereology, we reported a reduction in oligodendrocyte number in CA4 in schizophrenia and of granular neurons in the dentate gyrus (DG). Here, we aimed to replicate these findings in an independent sample. We used a stereological approach to investigate the numbers and densities of neurons, oligodendrocytes, and astrocytes in CA4 and of granular neurons in the DG of left and right hemispheres in 11 brains from men with schizophrenia and 11 brains from age- and sex-matched healthy controls. In schizophrenia, a decreased number and density of oligodendrocytes was detected in the left and right CA4, whereas mean volumes of CA4 and the DG and the numbers and density of neurons, astrocytes, and granular neurons were not different in patients and controls, even after adjustment of variables because of positive correlations with postmortem interval and age. Our results replicate the previously described decrease in oligodendrocytes bilaterally in CA4 in schizophrenia and point to a deficit in oligodendrocyte maturation or a loss of mature oligodendrocytes. These changes result in impaired myelination and neuronal decoupling, both of which are linked to altered functional connectivity and subsequent cognitive dysfunction in schizophrenia.
KW  - schizophrenia
KW  - hippocampus
KW  - CA4
KW  - dentate gyrus
KW  - postmortem
KW  - stereology
KW  - oligodendrocyte
KW  - neuron
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-290360
SN  - 2073-4409
VL  - 11
IS  - 20
ER  - 
TY  - JOUR
A1  - Tiane, Assia
A1  - Schepers, Melissa
A1  - Rombaut, Ben
A1  - Hupperts, Raymond
A1  - Prickaerts, Jos
A1  - Hellings, Niels
A1  - van den Hove, Daniel
A1  - Vanmierlo, Tim
T1  - From OPC to oligodendrocyte: an epigenetic journey
JF  - Cells
N2  - Oligodendrocytes provide metabolic and functional support to neuronal cells, rendering them key players in the functioning of the central nervous system. Oligodendrocytes need to be newly formed from a pool of oligodendrocyte precursor cells (OPCs). The differentiation of OPCs into mature and myelinating cells is a multistep process, tightly controlled by spatiotemporal activation and repression of specific growth and transcription factors. While oligodendrocyte turnover is rather slow under physiological conditions, a disruption in this balanced differentiation process, for example in case of a differentiation block, could have devastating consequences during ageing and in pathological conditions, such as multiple sclerosis. Over the recent years, increasing evidence has shown that epigenetic mechanisms, such as DNA methylation, histone modifications, and microRNAs, are major contributors to OPC differentiation. In this review, we discuss how these epigenetic mechanisms orchestrate and influence oligodendrocyte maturation. These insights are a crucial starting point for studies that aim to identify the contribution of epigenetics in demyelinating diseases and may thus provide new therapeutic targets to induce myelin repair in the long run.
KW  - oligodendrocyte
KW  - epigenetics
KW  - myelination
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193267
SN  - 2073-4409
VL  - 8
IS  - 10
ER  -