TY  - JOUR
A1  - Siegl, Christine
A1  - Prusty, Bhupesh K.
A1  - Karunakaran, Karthika
A1  - Wischhusen, Jörg
A1  - Rudel, Thomas
T1  - Tumor Suppressor p53 Alters Host Cell Metabolism to Limit Chlamydia trachomatis Infection
JF  - Cell Reports
N2  - Obligate intracellular bacteria depend entirely on nutrients from the host cell for their reproduction. Here, we show that obligate intracellular Chlamydia downregulate the central tumor suppressor p53 in human cells. This reduction of p53 levels is mediated by the PI3K-Akt signaling pathway, activation of HDM2, and subsequent proteasomal degradation of p53. The stabilization of p53 in human cells severely impaired chlamydial development and caused the loss of infectious particle formation. DNA-damage-induced p53 interfered with chlamydial development through downregulation of the pentose phosphate pathway (PPP). Increased expression of the PPP key enzyme glucose-6-phosphate dehydrogenase rescued the inhibition of chlamydial growth induced by DNA damage or stabilized p53. Thus, downregulation of p53 is a key event in the chlamydial life cycle that reprograms the host cell to create a metabolic environment supportive of chlamydial growth.
KW  - chlamydia trachomatis
KW  - tumor
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-118200
SN  - 2211-1247
VL  - 9
IS  - 3
ER  -