TY  - JOUR
A1  - Chumduri, Cindrilla
A1  - Turco, Margherita Y.
T1  - Organoids of the female reproductive tract
JF  - Journal of Molecular Medicine
N2  - Healthy functioning of the female reproductive tract (FRT) depends on balanced and dynamic regulation by hormones during the menstrual cycle, pregnancy and childbirth. The mucosal epithelial lining of different regions of the FRT—ovaries, fallopian tubes, uterus, cervix and vagina—facilitates the selective transport of gametes and successful transfer of the zygote to the uterus where it implants and pregnancy takes place. It also prevents pathogen entry. Recent developments in three-dimensional (3D) organoid systems from the FRT now provide crucial experimental models that recapitulate the cellular heterogeneity and physiological, anatomical and functional properties of the organ in vitro. In this review, we summarise the state of the art on organoids generated from different regions of the FRT. We discuss the potential applications of these powerful in vitro models to study normal physiology, fertility, infections, diseases, drug discovery and personalised medicine.
KW  - female reproductive tract
KW  - organoids
KW  - reproductive health
KW  - pregnancy
KW  - fertility
KW  - infection
KW  - cancers
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-328374
VL  - 99
IS  - 4
ER  -