TY  - JOUR
A1  - Schneider-Schaulies, Jürgen
A1  - Knauer, R.
A1  - Hünig, T.
A1  - Schimpl, A.
A1  - Wecker, E.
T1  - Induction of c-onc expression in polyclonally activated mouse lymphocytes
N2  - No abstract available
KW  - Lymphozyt
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54784
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Jürgen
A1  - Knauer, R.
A1  - Schimpl, A.
A1  - Wecker, E.
T1  - Cellular Oncogenes and lymphocyte activation
N2  - No abstract available
KW  - Lymphozyt
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54836
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Jürgen
A1  - Schimpl, A.
A1  - Wecker, E.
T1  - Kinetics of cellular oncogene expression in mouse lymphocytes II. Regulation of c-fos and c-myc gene expression
N2  - Newly isolated lymphocytes from mousespleensexpress the c-fos oncogene even in the absence of mitogen with maximal mRNA levels 60 min post preparation of single cell suspension, whereas c-myc mRNA Ievels increase only after mitogenic Stimulation with maximal mRNA Ievels 6 h post Stimulation. The half-lives of c-fos mRNA are generally very short; they increase from 14 min (after 30 min of culture) to 70 min (after 2 h of culture). The half-lives of c-myc mRNA decrease from 50 min (at 2 and 6 h post stimulation with concanavalin A) to 12 min (at 48 h post stimulation). The c-fos gene transcription is already tumed on in time-0 lymphocytes 10 min after disruption of the organ structure of the spleens and is down-regulated after 2 h and later. In nuclear run-on experiments with nonstimulated lymphocytes there is already significant transcription of the first exon of c-myc, but almost no elongation of the transcript to exon 2 and 3. In concanavalin A-treated lymphocytes elongation is stimulated about 5-fold within 6 h and returns to background levels at 48 h post Stimulation. · The nuclear run-on analyses of nonactivated lymphocytes showed a signal for RNA complementary to c-myc mRNA detected with a probe specific for the exon 1/intron 1 boundary of c-myc, which disappeared with increasing time of concanavalin A Stimulation. This anti-sense transcription may play a role in regulating the elongation of cmyc transcripts.
KW  - Lymphozyt
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54823
ER  -