TY  - THES
A1  - Xiao, Zheng
T1  - Blimp-1 Regulates Terminal Differentiation of T Cells
T1  - Regulation der terminalen Differenzierung von T-Zellen durch Blimp-1
N2  - The transcriptional repressor-Blimp-1 terminates differentiation of B lymphocytes as well as myeloid cells. Our data show that Blimp-1 is highly expressed in freshly isolated murine primary T lymphocytes, particularly its minor splice variant. Ectopic expression of Blimp-1 by retroviral transduction neither dramatically altered secretion of IFN-ã or IL-4 nor did it induce the ability to suppress as regulatory T cells. However, induction of Blimp-1 resulted in not only a significant reduction in the production of IL-2 but also an inability to proliferate as well as in the reduced viability. These results demonstrate that Blimp-1 might mark end stages of lineage differentiation in T cells.
KW  - Blimp-1
KW  - T- Zelle
KW  - Regluation
KW  - Blimp-1
KW  - T cell
KW  - Regulation
Y1  - 2004
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-10530
ER  -