TY - JOUR A1 - Falk, W. A1 - Ulrichs, Karin A1 - Müller-Ruchholtz, W. T1 - 15-Deoxyspergualin (a new guanidine-like drug) blocks T lymphocyte proliferation N2 - No abstract available KW - Chirurgie Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45215 ER - TY - JOUR A1 - Müller-Buchholtz, W. A1 - Leyhausen, G. A1 - Peterson, P. A1 - Schubert, G. A1 - Ulrichs, Karin T1 - A simple methodological principle for large scale extraction and purification of collagenase-digested islets N2 - No abstract available KW - Chirurgie Y1 - 1987 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44770 ER - TY - JOUR A1 - Ulrichs, Karin A1 - Winoto-Morbach, S. A1 - Hering, B. A1 - Müller-Ruchholtz, W. T1 - A Useful Biotechnological Approach to Solve the Problem of Graft Purity in Human Pancreatic Islet Transplantation N2 - No abstract available KW - Chirurgie Y1 - 1990 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45619 ER - TY - THES A1 - Fuhr, Sebastian T1 - Behandlungsoptionen Offene Abdomen Therapie - Entwicklung und Validierung eines multizentrischen Registers T1 - Treatment options Open Abdomen Therapy - Development and validation of a multicenter registry N2 - Die Offene Abdomen Therapie (OAT) stellt eine der größten Herausforderungen im Bereich der Chirurgie dar. Ziel war es ein offenes, kostenloses und internationales Register zu entwickeln, um eine Basis für zukünftige Therapien und den Weg zu einer evidenzbasierten Leitlinie zu legen. Es wurden 630 Fälle identifiziert welche mittels OAT behandelt wurden und im Rahmen einer gemischt retrospektiven als auch prospektiven Datenauswertung in das von uns entwickelte Register eingetragen. Schwerpunkte waren dabei einerseits die Praktikabilität des Registers zu testen als auch Einflussfaktoren für eine erfolgreiche OAT zu finden. Es konnte gezeigt werden, dass das Register in seiner Konzeption funktioniert und in der ersten Auswertungen Einflussfaktoren für eine erhöhte Faszienverschlussrate gefunden werden konnten. Der verbesserte Faszienverschluss am Ende der Therapie mit zeitgleich reduzierter Komplikationsrate ist möglich. Aus diesem Grund besitzt die konsequente Nutzung des Registers von behandelnden Einrichtungen, die wo immer mögliche lückenlose Dokumentation, sowie die multizentrische Auswertung der Daten einen hohen Stellenwert in Hinsicht auf Prävention, Therapie und Nachsorge der OAT. N2 - Open abdomen therapy (OAT) represents one of the greatest challenges in the field of surgery. The aim was to develop an open, free and international registry to provide a basis for future therapies and to pave the way for an evidence-based guideline. We identified 630 cases treated with OAT and entered them into the registry in a mixed retrospective and prospective data analysis. The main focus was to test the practicability of the registry as well as to find influencing factors for a successful OAT. It could be shown that the register works in its conception and in the first evaluations influencing factors for an increased fascial closure rate could be found. Improved fascial closure at the end of therapy with a simultaneously reduced complication rate is possible. For this reason, the consistent use of the registry by treating institutions, the complete documentation wherever possible, as well as the multicenter evaluation of the data is of high importance with regard to prevention, therapy and follow-up of OAT. KW - Chirurgie KW - Laparostomie KW - Laparotomie KW - Offene Abdomen Therapie KW - Open abdomen therapy KW - Registerstudie KW - Multizentrisches Register Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-257080 ER - TY - JOUR A1 - Laus, R. A1 - Ulrichs, Karin A1 - Müller-Ruchholtz, W. T1 - Carbohydrate-specific human heterophile antibodies in normal human sera that react with xenogeneic cells N2 - Human heterophile antibodies (HHA) that are present in normal human sera (NHS)play an important role in hyperacute xenograft rejection. The aim of this study was to analyze the occurrence, mode of action and molecular specificity of HHA in NHS that are directed against xenogeneic Iymphocytes (isolated from mouse, rat, guinea pig, rabbit, cattle and pig) and isolated rat pancreatic islets. All sera contained variable amounts of HHA that killed the target cells via the classical complement pathway. The cytotoxic activity of these HHA was specifically inhibited by certain carbohydrates (a-D-melibiose, ß-Iactose, ß-gentiobiose, ß-cellobiose, D-mannose, N-acetyl-ß-D-mannosamine and a-D-rhamnose) and by rat IgM. By means of affinity chromatography with immobilized inhibitors we obtained an antibody preparation of mainly IgG type from NHS (up to 3.5 mg/IO ml serum) that reacted strongly with rat lymphocytes and isolated rat pancreatic islets. Though thus far residual xenospecific antibody activity has remained in the sera even after multiple affinity chromatography, these data suggest that specific elimination of HHA is feasible and that it may be thus possible to overcome a major obstacle to xenotransplantation. KW - Immunobiologie KW - Chirurgie Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78271 ER - TY - THES A1 - Schäfer, Jeanette T1 - Carl Gustav Himly (1772-1837) : Vorlesungen über medicinische Chirurgie und Gehörkrankheiten ; Kommentierte Edition zweier studentischer Mitschriften T1 - Carl Gustav Himly (1772-1837) : Medical Surgery and Otology N2 - Inhaltsangabe zweier medizinischer Vorlesungen zur Medicinischen Chirurgie und Gehörkrankheiten von Carl Gustav Himly (1773 - 1835) um 1820 an der Universität Göttingen N2 - Medical lecture about medical surgery and otolgy, 19 th century KW - Hals-Nasen-Ohren-Heilkunde KW - Chirurgie KW - Göttingen / Universität KW - Carl Gustav Himly KW - Medizin 19. Jahrhundert KW - Carl Gustav Himly KW - Medical Surgery KW - 19. Century Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54574 ER - TY - JOUR A1 - Deltz, E. A1 - Müller-Hermelink, HK A1 - Ulrichs, Karin A1 - Thiede, A. A1 - Müller-Ruchholtz, W. T1 - Development of graft-versus-host reaction in various target organs after small intestine transplantation N2 - The GVHRIL foHowing transplantation of small intestine are different from those found after bone marrow transplantation or spleen cell injections in that they show a remarka ble, significant prevalence of lesions within the intestinal mucosa. These findings are consistent with the observation that jntestinal lymphocytes newly formed in mesenteric lymph nodes predominantly home in on the intestine again.& The degree of histologic alteration within different tissues indicates that the graft and the host may survive the lesions of the lymphatic tissues, whereas the severe intestinal lesions following GVHR may easily cause death of the recipient. With regard to clinical sman bowel transplantation two statements can be made: (l) GVHRIL play a significant role in small bowel trans~ plantation. (2) To minimize their biologic importance, a selective elimination of the graft's Jymph nodes by irradiation or surgical resection should be considered in view of the remarkable difference between GVHRIL in lymph nodes and in the graft's intestinal wall itself. KW - Chirurgie Y1 - 1981 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45459 ER - TY - JOUR A1 - Ulrichs, Karin A1 - Wang, H. A1 - Müller-Buchholtz, W. T1 - Down-regulation of xenophile antibodies by 15-deoxyspergualin in an experimental animal model N2 - No abstract available KW - Chirurgie Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44733 ER - TY - JOUR A1 - Wiegering, Armin A1 - Korb, Doreen A1 - Thalheimer, Andreas A1 - Kämmerer, Ulrike A1 - Allmanritter, Jan A1 - Matthes, Niels A1 - Linnebacher, Michael A1 - Schlegel, Nicolas A1 - Klein, Ingo A1 - Ergün, Süleyman A1 - Germer, Christoph-Thomas A1 - Otto, Christoph T1 - E7080 (Lenvatinib), a Multi-Targeted Tyrosine Kinase Inhibitor, Demonstrates Antitumor Activities Against Colorectal Cancer Xenografts N2 - Clinical prognosis of metastasized colorectal carcinoma (CRC) is still not at desired levels and novel drugs are needed. Here, we focused on the multi-tyrosine kinase inhibitor E7080 (Lenvatinib) and assessed its therapeutic efficacy against human CRC cell lines in vitro and human CRC xenografts in vivo. The effect of E7080 on cell viability was examined on 10 humanCRCcell lines and humanendothelial cells (HUVEC). The inhibitory effect of E7080 on VEGF-induced angiogenesis was studied in an ex vivo mouse aortic ring angiogenesis assay. In addition, the efficacy of E7080 against xenografts derived fromCRC cell lines and CRC patient resection specimenswithmutated KRASwas investigated in vivo. Arelatively low cytotoxic effect of E7080 on CRC cell viabilitywas observed in vitro. Endothelial cells (HUVEC)weremore susceptible to the incubation with E7080. This is in line with the observation that E7080 demonstrated an anti-angiogenic effect in a three-dimensional ex vivo mouse aortic ring angiogenesis assay. E7080 effectively disrupted CRC cell-mediated VEGF-stimulated growth of HUVEC in vitro. Daily in vivo treatment with E7080 (5 mg/kg) significantly delayed the growth of KRAS mutated CRC xenografts with decreased density of tumor-associated vessel formations and without tumor regression. This observation is in line with results that E7080 did not significantly reduce the number of Ki67-positive cells in CRC xenografts. The results suggest antiangiogenic activity of E7080 at a dosage thatwas well tolerated by nudemice. E7080 may provide therapeutic benefits in the treatment of CRC with mutated KRAS. KW - Chirurgie Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-111165 ER - TY - JOUR A1 - Ulrichs, Karin A1 - Müller-Ruchholtz, W. T1 - Expression of MHC Structures on Immunologically Reactive and Non Reactive Cells in Islets of Langerhans and Other Tissues N2 - No abstract available KW - Chirurgie Y1 - 1988 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45557 ER -