TY  - JOUR
A1  - Nagai, Michiaki
A1  - Förster, Carola Yvette
A1  - Dote, Keigo
T1  - Sex hormone-specific neuroanatomy of Takotsubo syndrome: is the insular cortex a moderator?
JF  - Biomolecules
N2  - Takotsubo syndrome (TTS), a transient form of dysfunction in the heart's left ventricle, occurs predominantly in postmenopausal women who have emotional stress. Earlier studies support the concept that the human circulatory system is modulated by a cortical network (consisting of the anterior cingulate gyrus, amygdala, and insular cortex (Ic)) that plays a pivotal role in the central autonomic nervous system in relation to emotional stressors. The Ic plays a crucial role in the sympathovagal balance, and decreased levels of female sex hormones have been speculated to change functional cerebral asymmetry, with a possible link to autonomic instability. In this review, we focus on the Ic as an important moderator of the human brain–heart axis in association with sex hormones. We also summarize the current knowledge regarding the sex-specific neuroanatomy in TTS.
KW  - insular cortex
KW  - autonomic nervous system
KW  - laterality
KW  - sex hormone
KW  - central autonomic network
KW  - Takotsubo cardiomyopathy
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-254776
SN  - 2218-273X
VL  - 12
IS  - 1
ER  - 
TY  - JOUR
A1  - Dakroub, Mohamad
A1  - Verma-Fuehring, Raoul
A1  - Agorastou, Vaia
A1  - Schön, Julian
A1  - Hillenkamp, Jost
A1  - Puppe, Frank
A1  - Loewen, Nils A.
T1  - Inter-eye correlation analysis of 24-h IOPs and glaucoma progression
JF  - Graefe’s Archive for Clinical and Experimental Ophthalmology
N2  - Purpose
To determine whether 24-h IOP monitoring can be a predictor for glaucoma progression and to analyze the inter-eye relationship of IOP, perfusion, and progression parameters.

Methods
We extracted data from manually drawn IOP curves with HIOP-Reader, a software suite we developed. The relationship between measured IOPs and mean ocular perfusion pressures (MOPP) to retinal nerve fiber layer (RNFL) thickness was analyzed. We determined the ROC curves for peak IOP (T\(_{max}\)), average IOP(T\(_{avg}\)), IOP variation (IOP\(_{var}\)), and historical IOP cut-off levels to detect glaucoma progression (rate of RNFL loss). Bivariate analysis was also conducted to check for various inter-eye relationships.

Results
Two hundred seventeen eyes were included. The average IOP was 14.8 ± 3.5 mmHg, with a 24-h variation of 5.2 ± 2.9 mmHg. A total of 52% of eyes with RNFL progression data showed disease progression. There was no significant difference in T\(_{max}\), T\(_{avg}\), and IOP\(_{var}\) between progressors and non-progressors (all p > 0.05). Except for T\(_{avg}\) and the temporal RNFL, there was no correlation between disease progression in any quadrant and T\(_{max}\), T\(_{avg}\), and IOP\(_{var}\). Twenty-four-hour and outpatient IOP variables had poor sensitivities and specificities in detecting disease progression. The correlation of inter-eye parameters was moderate; correlation with disease progression was weak.

Conclusion
In line with our previous study, IOP data obtained during a single visit (outpatient or inpatient monitoring) make for a poor diagnostic tool, no matter the method deployed. Glaucoma progression and perfusion pressure in left and right eyes correlated weakly to moderately with each other.

Key messages
What is known:
● Our prior study showed that manually obtained 24-hour inpatient IOP measurements in right eyes are poor predictors for glaucoma progression. The inter-eye relationship of 24-hour IOP parameters and disease progression on optical coherence tomography (OCT) has not been examined.
What we found:
● 24-hour IOP profiles of left eyes from the same study were a poor diagnostic tool to detect worsening glaucoma.
● Significant inter-eye correlations of various strengths were found for all tested parameters
KW  - glaucoma progression
KW  - nycthemeral intraocular pressure
KW  - right-left comparison
KW  - laterality
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-323831
VL  - 260
IS  - 10
ER  -