TY - CHAP A1 - Toepfer, Regina T1 - Sympathie und Tragik: Rezeptionslenkung im Hildebrandslied. T2 - Techniken der Sympathiesteuerung in Erzähltexten der Vormoderne: Potentiale und Probleme. N2 - Die Autorin verknüpft die Frage nach der Sympathiesteuerung mit dem Aspekt der Tragik, um auf diese Weise eine neue Perspektive auf den alt vertrauten und viel gedeuteten Erzähltext des 9. Jahrhunderts zu werfen. Indem sie zuerst das Verhältnis von Sympathie und Tragik allgemein bestimmt, dann die Steuerungselemente im ‘Hildebrandslied’ untersucht, die eine tragödienspezifische Wirkung hervorrufen, und sich schließlich mit der Rezeptionsgeschichte des ‘Hildebrandslieds’ auseinandersetzt, kann sie grundlegende Schlussfolgerungen zur Sympathielenkung durch tragisches Handeln ableiten. KW - Narratologie KW - Tragödie KW - Tragik KW - Althochdeutsche Literatur KW - Erzähltechnik KW - Rezeptionssteuerung KW - Sympathie Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-299178 SN - 978-3-8253-6491-5 PB - Universitätsverlag Winter CY - Heidelberg ER - TY - CHAP A1 - Kraft, Stephan T1 - Vom Umgang mit einem unerhörten Ereignis. Andreas Gryphius: "Ermordete Majestät. Oder Carolus Stuardus" T2 - Geschichte in Geschichten N2 - Kein Abstract verfügbar. KW - Andreas Gryphius: "Ermordete Majestät. Oder Carolus Stuardus" Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-282531 PB - Königshausen & Neumann CY - Würzburg ER - TY - JOUR A1 - Vaiopoulos, Aristeidis G. A1 - Kanakis, Meletios A. A1 - Kapsimali, Violetta A1 - Vaiopoulos, Georgios A1 - Kaklamanis, Phedon G. A1 - Zouboulis, Christos C. T1 - Juvenile Adamantiades-Behçet disease JF - Dermatology N2 - Adamantiades-Behçet disease (ABD) is a chronic, multisystemic, recurrent, inflammatory vascular disorder of unknown etiology. Patients with symptoms initially appearing at the age of 16 or less are considered as cases of juvenile-onset ABD (JABD). JABD is relatively rare compared to ABD of adults, and only case reports and case studies have been published regarding this subtype of the disease. Epidemiology, clinical features, diagnosis and treatment of JABD are discussed in this review. KW - Aphthae KW - Childhood KW - Epidemiological study KW - Genitoanal region KW - Adamantiades-Behçet disease KW - Behçet’s disease KW - Uveitis Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196616 SN - 1018-8665 SN - 1421-9832 N1 - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. VL - 232 IS - 2 SP - 129 EP - 136 ER - TY - JOUR A1 - Tomasek, Stefan T1 - Frauen- und Männerrollen in mittelhochdeutscher Kreuzzugslyrik JF - Das Mittelalter N2 - This article focuses on the effects that crusade motives woven into Middle High German courtly lovesongs have on gender binarism in these text. The analysis draws on two examples from the first period of Middle High German crusade poetry: Friedrich von Hausen, ‘Si darf mich des zîhen niet’ and Albrecht von Johansdorf, ‘Guote liute, holt die gâbe’. I examine whether the relation between lady and male speaker is altered by the crusader’s divine service and whether this affects the gender binarism in the songs. The article concludes with a discussion of the repercussions gender binarism has on the concepts of crusading in the two texts. KW - German crusade poetry KW - Friedrich von Hausen KW - Albrecht von Johansdorf KW - deutsche Kreuzzugslyrik KW - Friedrich von Hausen KW - Albrecht von Johansdorf Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-193356 SN - 2196-6869 SN - 0949-0345 N1 - Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. VL - 21 IS - 1 ER - TY - JOUR A1 - Schmid, Michael A1 - Steinlein, Claus A1 - Lomb, Christian A1 - Sperling, Karl A1 - Neitzel, Heidemarie T1 - 5-Methylcytosine-Rich Heterochromatin in the Indian Muntjac JF - Cytogenetic and Genome Research N2 - Two 5-methylcytosine (5-MeC)-rich heterochromatic regions were demonstrated in metaphase chromosomes of the Indian muntjac by indirect immunofluorescence using a monoclonal anti-5-MeC antibody. The metaphases were obtained from diploid and triploid cell lines. A major region is located in the ‘neck' of the 3;X fusion chromosome and can be detected after denaturation of the chromosomal DNA with UV-light irradiation for 1 h. It is located exactly at the border of the X chromosome and the translocated autosome 3. A minor region is found in the centromeric region of the free autosome 3 after denaturing the chromosomal DNA for 3 h or longer. The structure and possible function of the major hypermethylated region as barrier against spreading of the X-inactivation process into the autosome 3 is discussed. KW - heterochromatin KW - immunofluorescence KW - Indian muntjac KW - 5-Methylcytosine Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196701 SN - 1424-8581 SN - 1424-859X N1 - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. VL - 147 IS - 4 ER - TY - JOUR A1 - Schmid, Michael A1 - Steinlein, Claus A1 - Winking, Heinz T1 - Multicolor Spectral Analyses of Mitotic and Meiotic Mouse Chromosomes Involved in Multiple Robertsonian Translocations. I. The CD/Cremona Hybrid Strain JF - Cytogenetic and Genome Research N2 - Multicolor spectral analysis (spectral karyotyping) was applied to mitotic and male diakinetic chromosomes of hybrid mice carrying a unique system of 18 autosomal Robertsonian translocation chromosomes with alternating arm homologies. Only the autosomes 19 and the XY sex chromosomes are excluded from these Robertsonian translocations. The translocations, previously identified by conventional banding analyses, could be verified by spectral karyotyping. Besides the Robertsonian translocations, no other interchromosomal rearrangements were detected. In diakineses of male meiosis, the 18 metacentric Robertsonian translocation chromosomes form a very large meiotic ‘superring'. The predictable, specific order of the chromosomes along this ‘superring' was completely confirmed by multicolor spectral analysis. In the majority of diakineses analyzed, the free autosomal bivalent 19 and the XY sex bivalent form a conspicuous complex which tightly associates with the 12;14 Robertsonian translocation chromosome in the ‘superring'. KW - meiotic ‘superring’ KW - mouse KW - Robertsonian translocation chromosomes KW - spectral karyotyping Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-199013 SN - 1424-8581 SN - 1424-859X N1 - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. VL - 147 IS - 4 ER - TY - JOUR A1 - Schmid, Michael A1 - Steinlein, Claus A1 - Yano, Cassia F. A1 - Cioffi, Marcelo B. T1 - Hypermethylated Chromosome Regions in Nine Fish Species with Heteromorphic Sex Chromosomes JF - Cytogenetic and Genome Research N2 - Sites and amounts of 5-methylcytosine (5-MeC)-rich chromosome regions were detected in the karyotypes of 9 Brazilian species of Characiformes fishes by indirect immunofluorescence using a monoclonal anti-5-MeC antibody. These species, belonging to the genera Leporinus, Triportheus and Hoplias, are characterized by highly differentiated and heteromorphic ZW and XY sex chromosomes. In all species, the hypermethylated regions are confined to constitutive heterochromatin. The number and chromosome locations of hypermethylated heterochromatic regions in the karyotypes are constant and species-specific. Generally, heterochromatic regions that are darkly stained by the C-banding technique are distinctly hypermethylated, but several of the brightly fluorescing hypermethylated regions merely exhibit moderate or faint C-banding. The ZW and XY sex chromosomes of all 9 analyzed species also show species-specific heterochromatin hypermethylation patterns. The analysis of 5-MeC-rich chromosome regions contributes valuable data for comparative cytogenetics of closely related species and highlights the dynamic process of differentiation operating in the repetitive DNA fraction of sex chromosomes. KW - heterochromatin KW - heteromorphic sex chromosomes KW - hypermethylation KW - immunofluorescence KW - 5-Methylcytosine KW - fish Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196710 SN - 1424-8581 SN - 1424-859X N1 - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. VL - 147 IS - 2-3 ER - TY - JOUR A1 - Schmid, Michael A1 - Steinlein, Claus T1 - Chromosome Banding in Amphibia. XXXIII. Demonstration of 5-Methylcytosine-Rich Heterochromatin in Anura JF - Cytogenetic and Genome Research N2 - An experimental approach using monoclonal anti-5-methylcytosine (5-MeC) antibodies and indirect immunofluorescence was elaborated for detecting 5-MeC-rich chromosome regions in anuran chromosomes. This technique was applied to mitotic metaphases of 6 neotropical frog species belonging to 6 genera and 4 families. The hypermethylation patterns were compared with a variety of banding patterns obtained by conventional banding techniques. The hypermethylated DNA sequences are species-specific and located exclusively in constitutive heterochromatin. They are found in centromeric, pericentromeric, telomeric, and interstitial positions of the chromosomes and adjacent to nucleolus organizer regions. 5-MeC-rich DNA sequences can be embedded both in AT- and GC-rich repetitive DNA. The experimental parameters that have major influence on the reproducibility and quality of the anti-5-MeC antibody labeling are discussed. KW - Anura KW - heterochromatin KW - hypermethylated DNA KW - immunofluorescence KW - 5-Methylcytosine Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-199022 SN - 1424-8581 SN - 1424-859X N1 - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. VL - 148 IS - 1 ER - TY - JOUR A1 - Schmid, Michael A1 - Steinlein, Claus T1 - Chromosome Banding in Amphibia. XXXIV. Intrachromosomal Telomeric DNA Sequences in Anura JF - Cytogenetic and Genome Research N2 - The mitotic chromosomes of 4 anuran species were examined by various classical banding techniques and by fluorescence in situ hybridization using a (TTAGGG)\(_n\) repeat. Large intrachromosomal telomeric sequences (ITSs) were demonstrated in differing numbers and chromosome locations. A detailed comparison of the present results with numerous published and unpublished data allowed a consistent classification of the various categories of large ITSs present in the genomes of anurans and other vertebrates. The classification takes into consideration the total numbers of large ITSs in the karyotypes, their chromosomal locations and their specific distribution patterns. A new category of large ITSs was recognized to exist in anuran species. It consists of large clusters of ITSs located in euchromatic chromosome segments, which is in clear contrast to the large ITSs in heterochromatic chromosome regions known in vertebrates. The origin of the different categories of large ITSs in heterochromatic and euchromatic chromosome regions, their mode of distribution in the karyotypes and evolutionary fixation in the genomes, as well as their cytological detection are discussed. KW - heterochromatin KW - intrachromosomal telomeric sequences KW - Anura KW - euchromatin KW - evolutionary fixation Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196693 SN - 1424-8581 SN - 1424-859X N1 - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. VL - 148 IS - 2-3 ER - TY - JOUR A1 - Almanzar, Giovanni A1 - Klein, Matthias A1 - Schmalzing, Marc A1 - Hilligardt, Deborah A1 - El Hajj, Nady A1 - Kneitz, Hermann A1 - Wild, Vanessa A1 - Rosenwald, Andreas A1 - Benoit, Sandrine A1 - Hamm, Henning A1 - Tony, Hans-Peter A1 - Haaf, Thomas A1 - Goebeler, Matthias A1 - Prelog, Martina T1 - Disease Manifestation and Inflammatory Activity as Modulators of Th17/Treg Balance and RORC/FoxP3 Methylation in Systemic Sclerosis JF - International Archives of Allergy and Immunology N2 - Background: There is much evidence that T cells are strongly involved in the pathogenesis of localized and systemic forms of scleroderma (SSc). A dysbalance between FoxP3+ regulatory CD4+ T cells (Tregs) and inflammatory T-helper (Th) 17 cells has been suggested. Methods: The study aimed (1) to investigate the phenotypical and functional characteristics of Th17 and Tregs in SSc patients depending on disease manifestation (limited vs. diffuse cutaneous SSc, dcSSc) and activity, and (2) the transcriptional level and methylation status of Th17- and Treg-specific transcription factors. Results: There was a concurrent accumulation of circulating peripheral IL-17-producing CCR6+ Th cells and FoxP3+ Tregs in patients with dcSSc. At the transcriptional level, Th17- and Treg-associated transcription factors were elevated in SSc. A strong association with high circulating Th17 and Tregs was seen with early, active, and severe disease presentation. However, a diminished suppressive function on autologous lymphocytes was found in SSc-derived Tregs. Significant relative hypermethylation was seen at the gene level for RORC1 and RORC2 in SSc, particularly in patients with high inflammatory activity. Conclusions: Besides the high transcriptional activity of T cells, attributed to Treg or Th17 phenotype, in active SSc disease, Tregs may be insufficient to produce high amounts of IL-10 or to control proliferative activity of effector T cells in SSc. Our results suggest a high plasticity of Tregs strongly associated with the Th17 phenotype. Future directions may focus on enhancing Treg functions and stabilization of the Treg phenotype. KW - methylation KW - systemic sclerosis KW - suppression KW - Tregs KW - Th17 Y1 - 2016 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-196577 SN - 1018-2438 SN - 1423-0097 N1 - This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. VL - 171 IS - 2 ER -