TY  - JOUR
A1  - Wang, Hui
A1  - Li, Min-Yi
A1  - Katele, Félix Zongwe
A1  - Satyanandamurty, Tirumani
A1  - Wu, Jun
A1  - Bringmann, Gerhard
T1  - Decandrinin, an unprecedented \(C_9\)-spiro-fused 7,8-\( seco-ent\)-abietane from the Godavari mangrove \(Ceriops\ decandra\)
JF  - Beilstein Journal of Organic Chemistry
N2  - Decandrinin (1), an unprecedented \(C_9\)-spiro-fused 7,8-\(seco-ent\)-abietane, was obtained from the bark of an Indian mangrove, \(Ceriops\ decandra\), collected in the estuary of Godavari, Andhra Pradesh. The constitution and the relative configuration of 1 were determined by HRMS (ESI) and extensive NMR investigations, and the absolute configuration by circular dichroism (CD) and optical-rotatory dispersion (ORD) spectroscopy in combination with quantum-chemical calculations. Decandrinin is the first 7,8-\(seco-ent\)-abietane.
KW  - ceriops decandra
KW  - abietane
KW  - absolute configuration
KW  - circular dichroism
KW  - decandrinin
KW  - rhizophoraceae
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-119983
SN  - 1860-5397
VL  - 10
ER  - 
TY  - JOUR
A1  - Kunz, Anna Lena
A1  - Labes, Antje
A1  - Wiese, Jutta
A1  - Bruhn, Torsten
A1  - Bringmann, Gerhard
A1  - Imhoff, Johannes F.
T1  - Nature's Lab for Derivatization: New and Revised Structures of a Variety of Streptophenazines Produced by a Sponge-Derived Streptomyces Strain
JF  - Marine Drugs
N2  - Eight streptophenazines (A-H) have been identified so far as products of Streptomyces strain HB202, which was isolated from the sponge Halichondria panicea from the Baltic Sea. The variation of bioactivities based on small structural changes initiated further studies on new derivatives. Three new streptophenazines (I-K) were identified after fermentation in the present study. In addition, revised molecular structures of streptophenazines C, D, F and H are proposed. Streptophenazines G and K exhibited moderate antibacterial activity against the facultative pathogenic bacterium Staphylococcus epidermidis and against Bacillus subtilis. All tested compounds (streptophenazines G, I-K) also showed moderate activities against PDE 4B.
KW  - marine natural product
KW  - phenazine
KW  - Baltic Sea
KW  - streptomyces
KW  - halichondria panicea
KW  - obstructive pulmonary disease
KW  - phosphodiesterase-4 inhibitor
KW  - absolute configuration
KW  - biosynthesis
KW  - rofumilast
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-116816
SN  - 1660-3397
VL  - 12
IS  - 4
ER  -