TY  - JOUR
A1  - Tacke, R.
A1  - Strecker, M.
A1  - Sheldrick, W. S.
A1  - Heeg, E.
A1  - Berndt, B.
A1  - Knapstein, K. M.
T1  - Sila-Pharmaka, 14. Mitt. Darstellung und Eigenschaften sowie Kristall-und Molekülstruktur von Sila-Difenidol
JF  - Zeitschrift für Naturforschung B
N2  - Sila-difenidol (6b), a sila-analogue of the drug difenidol (6a), was synthesized according to Scheme 1. 6b and its new precursors 3 and 5 were characterized by their physical and chemical properties, and their structures confirmed by elementary analyses, 1H NMR and mass spectroscopy. 6 b crystallizes orthorhombic \(P2_12_12_1\) with a = 11.523(1), b = 14.366(4), c = 11.450(1) Å, Z = 4, \(D_{ber} = 1.14 gcm^{-3}\). The structure was refined to R = 0.050 for 1897 reflexions. A strong nearly linear intramolecular O-H···N hydrogen bond of 2.685 Å is observed. The anticholinergic, histaminolytic and musculotropic spasmolytic activities of 6 a and 6 b are reported.
KW  - sila-difenidol
KW  - syntheses
KW  - crystal structure
KW  - molecular structure
KW  - biological activity
Y1  - 1979
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128391
VL  - 34
IS  - 9
ER  -