TY - JOUR A1 - Dandekar, Thomas A1 - Argos, P. T1 - Three-dimensional structure of the 67k N-terminal Fragment of E.coli DNA Topoisomerase I N2 - No abstract available Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-29836 ER - TY - JOUR A1 - Dandekar, Thomas A1 - Argos, P. T1 - Folding the main chain of small proteins with the genetic algorithm N2 - No abstract available Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-29847 ER - TY - JOUR A1 - Vortkamp, Andrea A1 - Gessler, Manfred A1 - Paslier, D. Le A1 - Elaswarapu, R. A1 - Smith, S. A1 - Grzeschik, Karl-Heinz T1 - Isolation of a yeast artificial chromosome contig spanning the Greig cephalopolysyndactyly syndrome (GCPS) gene region N2 - Disruption of the zinc finger gene GLI3 has been shown to be the cause of Greig cephalopolysyndactyly syndrome (GCPS), at least in some GCPS translocation patients. To characterize this genomic region on human chromosome 7p13, we have isolated a VAC contig of more than 1000 kb including the GLI3 gene. In this contig the gene itself spans at least 200-250 kb. A CpG island is located in the vicinity of the 5' region of the known GLI3 cDNA, implying a potential promoter region. Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30182 ER - TY - JOUR A1 - Schmuck, R. A1 - Geise, W. A1 - Linsenmair, Karl Eduard T1 - Life cycle strategies and physiological adjustments of Reedfrog Tadpoles (Amphibia, Anura, Hyperoliidae) in relation to environmental conditions. N2 - The relationship between different degrees of intraspecific crowding of reedfrog tadpoles and their physiological responses to a deterioration of the natal pond water quality was examined under laboratory conditions. Tadpoles that were reared at a lower density metamorphosed significantly earlier than those raised at a higher density. As density increases, the average body length at metamorphosis decreases. However, at low tadpole density, a significantly higher diversity of body size classes among freshly metamorphosed froglets was observed than under more crowded conditions. Mortality increased during metamorphic climax and was inversely correlated with the tadpole density. In ephemeral ponds, an accumulation of nitrogenous wastes from metabolic processes and/or a concentration by evaporation in prolonged rainless periods can pose a considerable chemical stress to reedfrog tadpoles. Hyperolius viridiflavus ommatostictus responded to an increasing ammonia concentration with an activity increase of the ornithine cycle (intensified urea synthesis). hi contrast, Hyperolius marmoratus taeniatus exhibited a strong tolerance against high ammonia levels. A deterioration of the natal pond water quality caused H. v. ommatostictus and H. v. nitidulus tadpoles to adjust to harsher climatic conditions at the time of metamorphosis. This physiological preadjustment enabled the froglets to start feeding and growing immediately after metamorphosis even at low air humidity and rare precipitation events. In contrast, froglets that were raised in daily refreshed water exhibited high mortality rates if subjected to identical conditions. As one possible indicator of the actual climatic conditions prevailing in the surrounding terrestrial habitat, fluctuations in the water ammonia level are discussed. Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31009 ER - TY - JOUR A1 - Scheer, Ulrich T1 - Harold Garnet Callan 1917-1993 N2 - Professor Harold Gamet Callan, honorary member of the German Society for Cell Biology, died on the 3rd November 1993, at the age of 76. His name is inseparably connected with lampbrush chromosomes, the most spectacular and aesthetically ailuring form of chromosomes, which occupied the major part of his scientific career. " Mick" Callan's pioneering studies led to fruitful new concepts, served as a building block for many subsequent studies by others, and contributed enormously to our current understanding of chromosome organization and activity ... KW - Harold Garnet Callan Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-80789 ER - TY - CHAP A1 - Schreibman, Martin P. A1 - Schartl, Manfred A1 - Kallman, Klaus D. A1 - Magliulo-Cepriano, Lucia T1 - Molecular approaches to study the genetic regulation of the fish reproductive system N2 - No abstract available. KW - Fische Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86679 ER - TY - CHAP A1 - Altschmied, Joachim A1 - Schartl, Manfred T1 - Genetics and molecular biology of tumour formation in Xiphophorus N2 - No abstract available. KW - Schwertkärpfling KW - Tumor KW - Entstehung KW - Molekularbiologie KW - Genetik Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-69752 ER - TY - JOUR A1 - Argos, P. A1 - Dandekar, Thomas T1 - Delineating the main chain topology of four-helix bundle proteins using the genetic algorithm and knowledge based on the amino acid sequence alone N2 - No abstract available KW - Proteine KW - Strukturanalyse KW - Abstandsmessung Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33807 ER - TY - CHAP A1 - Fiala, Brigitte A1 - Rabenstein, R. A1 - Maschwitz, Ulrich T1 - Ant-attracting plant-structures: Food bodies of SE Asian Vitaceae N2 - No abstract available KW - Pflanzen Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-55177 ER - TY - JOUR A1 - Winkler, Christoph A1 - Wittbrodt, Joachim A1 - Lammers, Reiner A1 - Ullrich, Axel A1 - Schartl, Manfred T1 - Ligand-dependent tumor induction in medakafish embryos by a Xmrk receptor tyrosine kinase transgene N2 - Xmrk encodes a subclass 1 receptor tyrosine kinase (RTK) which has been cloned from the melanomainducing locus Tu of the poeciliid fish Xiphophorus. To demonstrate a high oncogenic potential in vivo we transferred the gene into early embryos of the closely related medakafish. Ectopic expression of the Xmrk oncogene under the control of a strong, constitutive promoter (CMVTk) led to the induction of embryonic tumors with high incidence, after short latency periods, and with a specific pattern of affected tissues. We demonstrate ligand-dependent transformation in vivo using a chimeric receptor consisting of the extracellular and transmembrane domains of the human EGF receptor (HER) and the cytoplasmatic domain of Xmrk. Expression of the chimeric receptor alone does not lead to ldnase activation or induction of tumors. Coexpression of the chimera with its corresponding ligand, human transforming growth factor alpha (bTGF(X), however, results in the activation of the chimeric RTK. In injected fish embryos the induction of the neoplastic growth is observed with similar incidence and tissue distribution as in embryos carrying the native Xmrk oncogene suggesting that the ligand as well as factors downstream of tbe RTK are required for tumor formation. In this study we show single-step induction of tumors by ectopic expression of RTKs in vivo substantiating tbe significance of autocrine stimulation in RTK induced tumors in vertebrales. KW - Japankärpfling KW - Ligand KW - Tumor Y1 - 1994 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-87107 ER -