TY  - JOUR
A1  - Guesmi, H.
A1  - Kraim, J. Ben
A1  - Alatrache, A.
A1  - Holzgrabe, U.
T1  - Hydrogen-deuterium (H/D) exchange reaction of acebutolol hydrochloride in D\(_{2}\)O and CD\(_{3}\)OD solution
JF  - Die Pharmazie
N2  - H/D exchange reactions can be observed by NMR spectroscopy of acebutolol (ACE). The results obtained showed deuterium incorporation at α-posi t ion of the carbonyl group of acebutolol, when using deuterium oxide or deuterated methanol as deuterium source and solvent. The spontaneous deuteration is proceeded by the following pathway CH\(_{3}\)→CH\(_{2}\)D→CHD→CD\(_{2}\), through a keto-enol tautomerization reaction. Furthermore, LC-MS / QTOF analyses have confirmed the proposed H/D exchange. In order to reduce the time of total deuteration observed at the acetyl group alkaline catalysts were employed.
KW  - Hydrogen-deuterium
KW  - exchange reaction
KW  - acebutolol
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-300833
SN  - 0031-7144
VL  - 77
IS  - 7
SP  - 217
EP  - 223
ER  -