TY  - JOUR
A1  - Ziouti, Fani
A1  - Rummler, Maximilian
A1  - Steyn, Beatrice
A1  - Thiele, Tobias
A1  - Seliger, Anne
A1  - Duda, Georg N.
A1  - Bogen, Bjarne
A1  - Willie, Bettina M.
A1  - Jundt, Franziska
T1  - Prevention of bone destruction by mechanical loading is not enhanced by the Bruton's tyrosine kinase inhibitor CC-292 in myeloma bone disease
JF  - International Journal of Molecular Sciences
N2  - Limiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent bone destruction and enhance bone mass in the MOPC315.BM.Luc model of MMBD. It is unknown whether treatment with the Bruton's tyrosine kinase inhibitor CC-292 (spebrutinib), which regulates osteoclast differentiation and function, augments the anabolic effect of mechanical loading. CC-292 was administered alone and in combination with axial compressive tibial loading in the MOPC315.BM.Luc model for three weeks. However, neither CC-292 alone nor its use in combination with mechanical loading was more effective in reducing osteolytic bone disease or rescuing bone mass than mechanical stimuli alone, as evidenced by microcomputed tomography (microCT) and histomorphometric analysis. Further studies are needed to investigate novel anti-myeloma and anti-resorptive strategies in combination with physical stimuli to improve treatment of MMBD.
KW  - multiple myeloma
KW  - cancer-induced bone disease
KW  - Bruton's tyrosine kinase inhibitor CC-292
KW  - skeletal mechanobiology
KW  - bone adaptation
KW  - mechanical loading
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284943
SN  - 1422-0067
VL  - 22
IS  - 8
ER  -