TY  - JOUR
A1  - Schulte, Annemarie
A1  - Blum, Robert
T1  - Shaped by leaky ER: Homeostatic Ca\(^{2+}\) fluxes
JF  - Frontiers in Physiology
N2  - At any moment in time, cells coordinate and balance their calcium ion (Ca\(^{2+}\)) fluxes. The term ‘Ca\(^{2+}\) homeostasis’ suggests that balancing resting Ca2+ levels is a rather static process. However, direct ER Ca\(^{2+}\) imaging shows that resting Ca\(^{2+}\) levels are maintained by surprisingly dynamic Ca\(^{2+}\) fluxes between the ER Ca\(^{2+}\) store, the cytosol, and the extracellular space. The data show that the ER Ca\(^{2+}\) leak, continuously fed by the high-energy consuming SERCA, is a fundamental driver of resting Ca\(^{2+}\) dynamics. Based on simplistic Ca\(^{2+}\) toolkit models, we discuss how the ER Ca\(^{2+}\) leak could contribute to evolutionarily conserved Ca\(^{2+}\) phenomena such as Ca\(^{2+}\) entry, ER Ca\(^{2+}\) release, and Ca\(^{2+}\) oscillations.
KW  - Ca2+ homeostasis
KW  - Ca2+ ion analysis
KW  - ER Ca2+ store
KW  - ER Ca2+ imaging
KW  - SERCA
KW  - store-operated Ca2+ entry
KW  - Ca2+ leak
KW  - Ca2+ oscillation
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-287102
SN  - 1664-042X
VL  - 13
ER  -