TY  - JOUR
A1  - Yousef, Yousef Al
A1  - Strzalkowska, Alicja
A1  - Hillenkamp, Jost
A1  - Rosentreter, André
A1  - Loewen, Nils A.
T1  - Comparison of a second-generation trabecular bypass (iStent inject) to ab interno trabeculectomy (Trabectome) by exact matching
JF  - Graefe's Archive for Clinical and Experimental Ophthalmology
N2  - Purpose
To achieve a highly balanced comparison of trabecular bypass stenting (IS2, iStent inject) with ab interno trabeculectomy (T, Trabectome) by exact matching.

Methods
Fifty-three IS2 eyes were matched to 3446 T eyes. Patients were matched using exact matching by baseline intraocular pressure (IOP), the number of glaucoma medications, and glaucoma type, and using nearest neighbor matching by age. Individuals without a close match were excluded. All surgeries were combined with phacoemulsification.

Results
A total of 78 eyes (39 in each group) could be matched as exact pairs with a baseline IOP of 18.3 ± 5.1 mmHg and glaucoma medications of 2.7 ± 1.2 in each. IOP in IS2 was reduced to 14.6 ± 4.2 mmHg at 3 months and in T to a minimum of 13.1 ± 3.2 mmHg at 1 month. In IS2, IOP began to rise again at 6 months, eventually exceeding baseline. At 24 months, IOP in IS2 was 18.8 ± 9.0 mmHg and in T 14.2 ± 3.5 mmHg. IS2 had a higher average IOP than T at all postoperative visits (p < 0.05 at 1, 12, 18 months). Glaucoma medications decreased to 2.0 ± 1.5 in IS2 and to 1.5 ± 1.4 in T.

Conclusion
T resulted in a larger and sustained IOP reduction compared with IS2 where a rebound occurred after 6 months to slightly above preoperative values.
KW  - glaucoma surgery
KW  - iStent
KW  - trabecular bypass stent
KW  - trabectome
KW  - ab interno trabeculectomy
KW  - exact matching
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-232613
SN  - 0721-832X
VL  - 258
ER  - 
TY  - THES
A1  - Verma-Führing, Raoul
T1  - Die Trabekulopunktion als Prädiktiver Test für den Erfolg der Ab Interno Trabekulektomie im Schweineaugenmodell
T1  - Trabeculopuncture as Predictive Test for the Outcome of Ab Interno Trabeculectomy in Porcine Anterior Segments
N2  - To investigate trabeculopuncture (TP) for predicting the outcome of ab interno trabeculectomy (AIT). Ex vivo porcine anterior segments were perfused and sequentially underwent two procedures, TP and AIT. We concluded that a 10% reduction in IOP after TP can be used to predict the success (>20% IOP decrease) of AIT in porcine eyes. As porcine eyes share many similarities with human eyes, our findings may have implications on the validity of this test as a predictor for surgical outcomes of AITs in humans.
N2  - Wir untersuchten die Trabekulopunktion (TP) zur Vorhersage des Erfolgs einer Ab Interno Trabekulektomie (AIT) an einem ex vivo Schweineaugen-Perfusionsmodell. Die Schweineaugen wurden nacheinander zwei Verfahren (TP und AIT) unterzogen. Wir kamen zu dem Schluss, dass eine 10-prozentige Senkung des Augeninnendrucks nach der TP zur Vorhersage des Erfolgs (>20-prozentige Senkung des Augeninnendrucks) einer AIT in Schweineaugen verwendet werden kann. Schweineaugen weisen viele Ähnlichkeiten mit menschlichen Augen auf. Die Implementation eines solchen Tests zur Vorhersage des chirurgischen Erfolgs einer AIT beim Menschen wäre von hoher klinischer Relevanz.
KW  - Glaukom
KW  - Goniotomie
KW  - Ab Interno Trabekulektomie
KW  - Trabekulopunktion
KW  - Glaucoma
KW  - trabecular meshwork
KW  - trabeculopuncture
KW  - ab interno trabeculectomy
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-282633
ER  -