TY  - JOUR
A1  - Koutsilieri, E.
A1  - Lutz, M. B.
A1  - Scheller, C.
T1  - Autoimmunity, dendritic cells and relevance for Parkinson’s disease
JF  - Journal of Neural Transmission
N2  - Innate and adaptive immune responses in neurodegenerative diseases have become recently a focus of research and discussions. Parkinson’s disease (PD) is a neurodegenerative disorder without known etiopathogenesis. The past decade has generated evidence for an involvement of the immune system in PD pathogenesis. Both inflammatory and autoimmune mechanisms have been recognized and studies have emphasized the role of activated microglia and T-cell infiltration. In this short review, we focus on dendritic cells, on their role in initiation of autoimmune responses, we discuss aspects of neuroinflammation and autoimmunity in PD, and we report new evidence for the involvement of neuromelanin in these processes.
KW  - Parkinson
KW  - dendritic cells
KW  - autoimmunity
KW  - immune neuromelanin
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-132308
VL  - 120
ER  -