TY  - JOUR
A1  - Grube, Maike Miriam
A1  - Koennecke, Hans-Christian
A1  - Walter, Georg
A1  - Meisel, Andreas
A1  - Sobesky, Jan
A1  - Nolte, Christian Hans
A1  - Wellwood, Ian
A1  - Heuschmann, Peter Ulrich
T1  - Influence of Acute Complications on Outcome 3 Months after Ischemic Stroke
JF  - PLOS ONE
N2  - Background: Early medical complications are potentially modifiable factors influencing in-hospital outcome. We investigated the influence of acute complications on mortality and poor outcome 3 months after ischemic stroke.
Methods: Data were obtained from patients admitted to one of 13 stroke units of the Berlin Stroke Registry (BSR) who participated in a 3-months-follow up between June 2010 and September 2012. We examined the influence of the cumulative number of early in-hospital complications on mortality and poor outcome (death, disability or institutionalization) 3 months after stroke using multivariable logistic regression analyses and calculated attributable fractions to determine the impact of early complications on mortality and poor outcome. 
Results: A total of 2349 ischemic stroke patients alive at discharge from acute care were included in the analysis. Older age, stroke severity, pre-stroke dependency and early complications were independent predictors of mortality 3 months after stroke. Poor outcome was independently associated with older age, stroke severity, pre-stroke dependency, previous stroke and early complications. More than 60% of deaths and poor outcomes were attributed to age, pre-stroke dependency and stroke severity and in-hospital complications contributed to 12.3% of deaths and 9.1% of poor outcomes 3 months after stroke.
Conclusion: The majority of deaths and poor outcomes after stroke were attributed to non-modifiable factors. However, early in-hospital complications significantly affect outcome in patients who survived the acute phase after stroke, underlining the need to improve prevention and treatment of complications in hospital.
KW  - hospital medical complications
KW  - quality-of-care
KW  - term mortality
KW  - Barthel-Index
KW  - rankin scale
KW  - risk-factors
KW  - trial
KW  - reliability
KW  - dependency
KW  - predictors
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128362
SN  - 1932-6203
VL  - 8
IS  - 9
ER  -