TY  - JOUR
A1  - Schmitter, Marc
A1  - Bömicke, Wolfgang
A1  - Behnisch, Rouven
A1  - Lorenzo Bermejo, Justo
A1  - Waldecker, Moritz
A1  - Rammelsberg, Peter
A1  - Ohlmann, Brigitte
T1  - Ceramic crowns and sleep bruxism: first results from a randomized trial
JF  - Journal of Clinical Medicine
N2  - Background: This randomized clinical trial was conducted to assess whether sleep bruxism (SB) is associated with an increased rate of technical complications (ceramic defects) in lithium disilicate (LiDi) or zirconia (Z) molar single crowns (SCs). Methods: Adult patients were classified as affected or unaffected by SB based on structured questionnaires, clinical signs, and overnight portable electromyography (BruxOff) and block randomized into four groups according to SB status and crown material (LiDi or Z): LiDi-SB (n = 29), LiDi-no SB (n = 24), Z-SB (n = 23), and Z-no SB (n = 27). Differences in technical complications (main outcome) and survival and success rates (secondary outcomes) one year after crown cementation were assessed using Fisher’s exact test with significance level α = 0.05. Results: No technical complications occurred. Restoration survival rates were 100% in the LiDi-SB and LiDi-no SB groups, 95.7% in the Z-SB group, and 96.3% in the Z-no SB group (p > 0.999). Success rates were 96.6% in the LiDi-SB group, 95.8% in the LiDi-no SB group (p > 0.999), 91.3% in the Z-SB group, and 96.3% in the Z-no SB group (p ≥ 0.588). Conclusions: With a limited observation time and sample size, no effect of SB on technical complication, survival, and success rates of molar LiDi and Z SCs was detected.
KW  - bruxism
KW  - cad-cam
KW  - ceramics
KW  - clinical studies/trials
KW  - prosthetic dentistry/prosthodontics
KW  - clinical outcomes
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-301480
SN  - 2077-0383
VL  - 12
IS  - 1
ER  - 
TY  - JOUR
A1  - Diloksumpan, Paweena
A1  - de Ruijter, Mylène
A1  - Castilho, Miguel
A1  - Gbureck, Uwe
A1  - Vermonden, Tina
A1  - van Weeren, P René
A1  - Malda, Jos
A1  - Levato, Riccardo
T1  - Combining multi-scale 3D printing technologies to engineer reinforced hydrogel-ceramic interfaces
JF  - Biofabrication
N2  - Multi-material 3D printing technologies that resolve features at different lengths down to the microscale open new avenues for regenerative medicine, particularly in the engineering of tissue interfaces. Herein, extrusion printing of a bone-biomimetic ceramic ink and melt electrowriting (MEW) of spatially organized polymeric microfibres are integrated for the biofabrication of an osteochondral plug, with a mechanically reinforced bone-to-cartilage interface. A printable physiological temperature-setting bioceramic, based on α-tricalcium phosphate, nanohydroxyapatite and a custom-synthesized biodegradable and crosslinkable poloxamer, was developed as bone support. The mild setting reaction of the bone ink enabled us to print directly within melt electrowritten polycaprolactone meshes, preserving their micro-architecture. Ceramic-integrated MEW meshes protruded into the cartilage region of the composite plug, and were embedded with mechanically soft gelatin-based hydrogels, laden with articular cartilage chondroprogenitor cells. Such interlocking design enhanced the hydrogel-to-ceramic adhesion strength >6.5-fold, compared with non-interlocking fibre architectures, enabling structural stability during handling and surgical implantation in osteochondral defects ex vivo. Furthermore, the MEW meshes endowed the chondral compartment with compressive properties approaching those of native cartilage (20-fold reinforcement versus pristine hydrogel). The osteal and chondral compartment supported osteogenesis and cartilage matrix deposition in vitro, and the neo-synthesized cartilage matrix further contributed to the mechanical reinforcement at the ceramic-hydrogel interface. This multi-material, multi-scale 3D printing approach provides a promising strategy for engineering advanced composite constructs for the regeneration of musculoskeletal and connective tissue interfaces.
KW  - biofabrication
KW  - melt electrowriting
KW  - bioinspired interface
KW  - bone and cartilage tissue engineering
KW  - microfibres
KW  - ceramics
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-254005
VL  - 12
IS  - 2
ER  -