TY  - JOUR
A1  - Balonov, Ilja
A1  - Kurlbaum, Max
A1  - Koschker, Ann-Cathrin
A1  - Stier, Christine
A1  - Fassnacht, Martin
A1  - Dischinger, Ulrich
T1  - Changes in plasma metabolomic profile following bariatric surgery, lifestyle intervention or diet restriction — insights from human and rat studies
JF  - International Journal of Molecular Sciences
N2  - Although bariatric surgery is known to change the metabolome, it is unclear if this is specific for the intervention or a consequence of the induced bodyweight loss. As the weight loss after Roux-en-Y Gastric Bypass (RYGB) can hardly be mimicked with an evenly effective diet in humans, translational research efforts might be helpful. A group of 188 plasma metabolites of 46 patients from the randomized controlled Würzburg Adipositas Study (WAS) and from RYGB-treated rats (n = 6) as well as body-weight-matched controls (n = 7) were measured using liquid chromatography tandem mass spectrometry. WAS participants were randomized into intensive lifestyle modification (LS, n = 24) or RYGB (OP, n = 22). In patients in the WAS cohort, only bariatric surgery achieved a sustained weight loss (BMI −34.3% (OP) vs. −1.2% (LS), p ≤ 0.01). An explicit shift in the metabolomic profile was found in 57 metabolites in the human cohort and in 62 metabolites in the rodent model. Significantly higher levels of sphingolipids and lecithins were detected in both surgical groups but not in the conservatively treated human and animal groups. RYGB leads to a characteristic metabolomic profile, which differs distinctly from that following non-surgical intervention. Analysis of the human and rat data revealed that RYGB induces specific changes in the metabolome independent of weight loss.
KW  - metabolomics
KW  - phosphatidylcholines
KW  - sphingolipids
KW  - branched-chain amino acids
KW  - obesity
KW  - Roux-en-Y Gastric Bypass
KW  - rodent model
KW  - insulin resistance
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-304462
SN  - 1422-0067
VL  - 24
IS  - 3
ER  - 
TY  - THES
A1  - Weidner, Magdalena Theodora
T1  - Brain serotonin throughout development - for better and for worse
T1  - Der Effekt von Serotonin im sich entwickelnden Gehirn - in guten wie in schlechten Tagen
N2  - The work presented in this thesis covers the effects of early-life adversity in the context of altered serotonin (5-HT; 5-hydroxytryptamine) system functioning in mice. The main body is focussing on a screening approach identifying molecular processes, potentially involved in distinct behavioural manifestations that emerge from or are concomitant with early adversity and, with regard to some behavioural manifestations, dependent on the functioning of the 5-HT system.
N2  - Diese Arbeit berichtet Ergebnisse der umfassenden Erforschung des Einflusses von aversiven Bedingungen während der pränatalen und frühkindlichen Entwicklungsphase, unter dem Einfluss genetischer Variationen des serotonergen (5-HT, 5-Hydroxytryptamin) Systems, im Mausmodel. Der Hauptfokus der Thesis lag bei der hypothesenfreien Untersuchung der Konsequenzen, die durch den kombinierten Effekt aversiver Bedingungen, und genetischer Prädisposition ausgelöst werden, sowie, final, der Ermittlung potentieller Kandidatengene, die an der Manifestierung verhaltensbezogener Konsequenzen beteiligt sein können sowie durch epigenetische Mechanismen reguliert werden.
KW  - Gehirn
KW  - Serotonin
KW  - Entwicklung
KW  - Stress
KW  - epigenetics
KW  - early-life stress
KW  - rodent model
KW  - behaviour
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-163345
SN  - 978-94-6233-940-8
N1  - This document is also published by the University library Maastricht. Maastricht University holds the same rights as University of Würzburg
PB  - Magdalena T. Weidner
CY  - Maastricht, the Netherlands
ER  -