TY  - JOUR
A1  - Doron, D. A.
A1  - McCarron, D. M.
A1  - Heldman, E.
A1  - Sirén, Anna-Leena
A1  - Spatz, M.
A1  - Feuerstein, G.
A1  - Pollard, H. B.
A1  - Hallenbeck, J. M.
T1  - Comparison of stimulated tissue factor expression by brain microvascular endothelial cells from normotensive (WKY) and hypertensive (SHR) rats
N2  - The amounts of tissue factor (TF) expressed by brain microvascular endothelial cells (BMECs) from normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were compared after stimulating the cells with different doses of lipopolysaccharide (LPS), thrombin, phorbol myristic acid (PMA), Ca\(^{2+}\)·ionophore (A23187), or tumor necrosis factor (TNF) and interleukin·l (IL.l). Treatment ofcultured BMECs fron. WKY and SHR with all of these factors dose·dependently increased their total amount of TF; no substantive differences in the Ieveis of enhanced TF expression were observed between WKY and SHR BMECs. We conclude that stimulated endothelium from rats with hypertension, a major stroke risk factor, is not hyperresponsive with respect to TF expression when compared to normotensive controls.
KW  - Neurobiologie
KW  - Endothelium
KW  - Thromboplastin
KW  - Lipopolysaccharide
Y1  - 1992
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63032
ER  - 
TY  - JOUR
A1  - Sirén, Anna-Leena
A1  - McCarron, R. M.
A1  - Liu, Y.
A1  - Barone, F.
A1  - Spatz, M.
A1  - Feuerstein, G.
A1  - Hallenbeck, J. M.
T1  - Perivascular monocyte/macrophage interaction with endothelium as a mechanism through which stroke-risk factors operate to increase stroke likelihood. Research Initiatives in Vascular Disease; SPECIAL COMMUNICATION
N2  - No abstract available
KW  - Neurobiologie
Y1  - 1993
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63006
ER  - 
TY  - JOUR
A1  - McCarron, R. M.
A1  - Wang, L.
A1  - Sirén, Anna-Leena
A1  - Spatz, M.
A1  - Hallenbeck, J. M.
T1  - Monocyte adhesion to cerebromicrovascular endothelial cells derived from hypertensive and normotensive rats
N2  - No abstract available
KW  - Neurobiologie
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62960
ER  -