TY  - JOUR
A1  - Glaser, Jan
A1  - Schultheis, Martina
A1  - Moll, Heidrun
A1  - Hazra, Banasri
A1  - Holzgrabe, Ulrike
T1  - Antileishmanial and Cytotoxic Compounds from Valeriana wallichii and Identification of a Novel Nepetolactone Derivative
JF  - Molecules
N2  - The chloroform extract of Valeriana wallichii (V. wallichii) rhizomes was investigated to elucidate the structures responsible for reported antileishmanial activity. Besides bornyl caffeate (1, already been reported by us previously), bioassay-guided fractionation resulted in two additional cinnamic acid derivatives 2–3 with moderate leishmanicidal activity. The structure of a novel nepetolactone derivative 4 having a cinnamic acid moiety was elucidated by means of spectral analysis. To the best of our knowledge villoside aglycone (5) was isolated from this plant for the first time. The bioassay-guided fractionation yielded two new (compounds 6–7) and two known valtrates (compounds 8–9) with leishmanicidal potential against Leishmania major (L. major) promastigotes. In addition, β-bisabolol (10), α-kessyl alcohol (11), valeranone (12), bornyl isovalerate (13) and linarin-2-O-methylbutyrate (14) were identified. This is the first report on the isolation of 4'-demethylpodophyllotoxin (15), podophyllotoxin (16) and pinoresinol (17) in V. wallichii. In total thirteen known and four new compounds were identified from the extract and their cytotoxic and antileishmanial properties were evaluated.
KW  - novel nepetolactone derivative
KW  - cytotoxicity
KW  - antileishmanial
KW  - V. wallichii
KW  - podophyllotoxin
KW  - valtrates
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-125320
VL  - 20
IS  - 4
ER  - 
TY  - THES
A1  - Glaser, Jan
T1  - Antileishmanial compounds from Nature - Elucidation of the active principles of an extract from Valeriana wallichii rhizomes
T1  - Antileishmaniale Wirkstoffe aus der Natur - Aufklärung des Wirkprinzips eines Wurzelextraktes von Valeriana wallichii
N2  - This study is dealing with the bioactivity-guided fractionation of a chloroform extract from pulverized rhizomes of Valeriana wallichii with focus on isolation and structure elucidation of the antileishmanial active principles.
N2  - Die vorliegende Studie beschäftigt sich mit der bioaktivitätsgeleiteten Fraktionierung eines Chloroformextraktes aus pulverisierten Rhizomen von Valeriana wallichii mit Schwerpunkt auf der Isolierung und Strukturaufklärung des antileishmanialen Wirkprinzips.
KW  - Leishmaniose
KW  - Valeriana wallichii
KW  - Extrakt
KW  - Rhizom
KW  - Naturstoff
KW  - natural products
KW  - antileishmanial
KW  - Valeriana wallichii
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-129140
ER  -