TY  - JOUR
A1  - Rödel, Michaela
A1  - Baumann, Katrin
A1  - Groll, Jürgen
A1  - Gbureck, Uwe
T1  - Simultaneous structuring and mineralization of silk fibroin scaffolds
JF  - Journal of Tissue Engineering
N2  - Silk fibroin is commonly used as scaffold material for tissue engineering applications. In combination with a mineralization with different calcium phosphate phases, it can also be applied as material for bone regeneration. Here, we present a study which was performed to produce mineralized silk fibroin scaffolds with controlled macroporosity. In contrast to former studies, our approach focused on a simultaneous gelation and mineralization of silk fibroin by immersion of frozen silk fibroin monoliths in acidic calcium phosphate solutions. This was achieved by thawing frozen silk fibroin monoliths in acidic calcium phosphate solution, leading to the precipitation of monocalcium phosphate within the silk fibroin matrix. In the second approach, a conversion of incorporated -tricalcium phosphate particles into brushite was successfully achieved. Furthermore, a controlled cryostructuring process of silk fibroin scaffolds was carried out leading to the formation of parallel-oriented pores with diameters of 30-50 mu m.
KW  - Brushite
KW  - calcium phosphate
KW  - cryostructuring
KW  - hydrogel
KW  - mineralization
KW  - silk fibroin scaffolds
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226427
VL  - 9
ER  -