TY  - JOUR
A1  - Ungern-Sternberg, Saskia N. I. von
A1  - Zernecke, Alma
A1  - Seizer, Peter
T1  - Extracellular matrix metalloproteinase inducer EMMPRIN (CD147) in cardiovascular disease
JF  - International Journal of Molecular Sciences
N2  - The receptor EMMPRIN is involved in the development and progression of cardiovascular diseases and in the pathogenesis of myocardial infarction. There are several binding partners of EMMPRIN mediating the effects of EMMPRIN in cardiovascular diseases. EMMPRIN interaction with most binding partners leads to disease progression by mediating cytokine or chemokine release, the activation of platelets and monocytes, as well as the formation of monocyte-platelet aggregates (MPAs). EMMPRIN is also involved in atherosclerosis by mediating the infiltration of pro-inflammatory cells. There is also evidence that EMMPRIN controls energy metabolism of cells and that EMMPRIN binding partners modulate intracellular glycosylation and trafficking of EMMPRIN towards the cell membrane. In this review, we systematically discuss these multifaceted roles of EMMPRIN and its interaction partners, such as Cyclophilins, in cardiovascular disease.
KW  - cardiovascular disease
KW  - immunoglobulin superfamily
KW  - inflammation
KW  - platelets
KW  - monocyte-platelet aggregates
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-285014
SN  - 1422-0067
VL  - 19
IS  - 2
ER  -