TY  - JOUR
A1  - Batzke, Katharina
A1  - Büchel, Gabriele
A1  - Hansen, Wiebke
A1  - Schramm, Alexander
T1  - TrkB-target Galectin-1 impairs immune activation and radiation responses in neuroblastoma: implications for tumour therapy
JF  - International Journal of Molecular Sciences
N2  - Galectin-1 (Gal-1) has been described to promote tumour growth by inducing angiogenesis and to contribute to the tumour immune escape. We had previously identified up-regulation of Gal-1 in preclinical models of aggressive neuroblastoma (NB), the most common extracranial tumour of childhood. While Gal-1 did not confer a survival advantage in the absence of exogenous stressors, Gal-1 contributed to enhanced cell migratory and invasive properties. Here, we review these findings and extend them by analyzing Gal-1 mediated effects on immune cell regulation and radiation resistance. In line with previous results, cell autonomous effects as well as paracrine functions contribute to Gal-1 mediated pro-tumourigenic functions. Interfering with Gal-1 functions in vivo will add to a better understanding of the role of the Gal-1 axis in the complex tumour-host interaction during immune-, chemo- and radiotherapy of neuroblastoma.
KW  - Galectin-1
KW  - radiation response
KW  - neuroblastoma
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-285097
SN  - 1422-0067
VL  - 19
IS  - 3
ER  -