TY - JOUR A1 - Abimannan, Nagarajan A1 - Sumathi, G. A1 - Krishnarajasekhar, O. R. A1 - Sinha, Bhanu A1 - Krishnan, Padma T1 - Clonal Clusters and Virulence Factors of Methicillin-Resistant \(Staphylococcus\) \(Aureus\): Evidence for Community-Acquired Methicillin-Resistant \(Staphylococcus\) \(Aureus\) Infiltration into Hospital Settings in Chennai, South India JF - Indian Journal of Medical Microbiology N2 - Background and Objective: Staphylococcus aureus is one of the major pathogens of nosocomial infections as wells as community-acquired (CA) infections worldwide. So far, large-scale comprehensive molecular and epidemiological characterisation of S. aureus from very diverse settings has not been carried out in India. The objective of this study is to evaluate the molecular, epidemiological and virulence characteristics of S. aureus in both community and hospital settings in Chennai, southern India. Methods: S. aureus isolates were obtained from four different groups (a) healthy individuals from closed community settings, (b) inpatients from hospitals, (c) outpatients from hospitals, representing isolates of hospital-community interface and (d) HIV-infected patients to define isolates associated with the immunocompromised. Antibiotic susceptibility testing, multiplex polymerase chain reactions for detection of virulence and resistance determinants, molecular typing including Staphylococcal cassette chromosome mec (SCCmec) and agr typing, were carried out. Sequencing-based typing was done using spa and multilocus sequence typing (MLST) methods. Clonal complexes (CC) of hospital and CA methicillin-resistant S. aureus (MRSA) were identified and compared for virulence and resistance. Results and Conclusion: A total of 769 isolates of S. aureus isolates were studied. The prevalence of MRSA was found to be 7.17%, 81.67%, 58.33% and 22.85% for groups a, b, c and d, respectively. Of the four SCCmec types (I, III, IV and V) detected, SCCmec V was found to be predominant. Panton-Valentine leucocidin toxin genes were detected among MRSA isolates harbouring SCCmec IV and V. A total of 78 spa types were detected, t657 being the most prevalent. 13 MLST types belonging to 9 CC were detected. CC1 (ST-772, ST-1) and CC8 (ST238, ST368 and ST1208) were found to be predominant among MRSA. CA-MRSA isolates with SCCmec IV and V were isolated from all study groups including hospitalised patients and were found to be similar by molecular tools. This shows that CA MRSA has probably infiltrated into the hospital settings. KW - Community-acquired methicillin-resistant Staphylococcus aureus KW - HIV KW - hospital-acquired methicillin-resistant Staphylococcus aureus KW - innate immune evasions KW - MLST KW - microbial surface component recognising adhesive matrix molecules KW - spa typing KW - ST 772 KW - Inducible Clindamycin Resistance KW - Valentine Leukocidin Genes KW - Multiplex PCR KW - Nasal Carriage KW - Colonization KW - Prevalence KW - Emergence KW - Skin Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-226963 VL - 37 IS - 3 ER - TY - JOUR A1 - Salinger, Tim A1 - Hu, Kai A1 - Liu, Dan A1 - Taleh, Scharoch A1 - Herrmann, Sebastian A1 - Oder, Daniel A1 - Gensler, Daniel A1 - Müntze, Jonas A1 - Ertl, Georg A1 - Lorenz, Kristina A1 - Frantz, Stefan A1 - Weidemann, Frank A1 - Nordbeck, Peter T1 - Association between Comorbidities and Progression of Transvalvular Pressure Gradients in Patients with Moderate and Severe Aortic Valve Stenosis JF - Cardiology Research and Practice N2 - Background. Fast progression of the transaortic mean gradient (P-mean) is relevant for clinical decision making of valve replacement in patients with moderate and severe aortic stenosis (AS) patients. However, there is currently little knowledge regarding the determinants affecting progression of transvalvular gradient in AS patients. Methods. This monocentric retrospective study included consecutive patients presenting with at least two transthoracic echocardiography examinations covering a time interval of one year or more between April 2006 and February 2016 and diagnosed as moderate or severe aortic stenosis at the final echocardiographic examination. Laboratory parameters, medication, and prevalence of eight known cardiac comorbidities and risk factors (hypertension, diabetes, coronary heart disease, peripheral artery occlusive disease, cerebrovascular disease, renal dysfunction, body mass index >= 30 Kg/m(2), and history of smoking) were analyzed. Patients were divided into slow (P-mean < 5 mmHg/year) or fast (P-mean >= 5 mmHg/year) progression groups. Results. A total of 402 patients (mean age 78 +/- 9.4 years, 58% males) were included in the study. Mean follow-up duration was 3.4 +/- 1.9 years. The average number of cardiac comorbidities and risk factors was 3.1 +/- 1.6. Average number of cardiac comorbidities and risk factors was higher in patients in slow progression group than in fast progression group (3.3 +/- 1.5 vs 2.9 +/- 1.7; P = 0.036). Patients in slow progression group had more often coronary heart disease (49.2% vs 33.6%; P = 0.003) compared to patients in fast progression group. LDL-cholesterol values were lower in the slow progression group (100 +/- 32.6 mg/dl vs 110.8 +/- 36.6 mg/dl; P = 0.005). Conclusion. These findings suggest that disease progression of aortic valve stenosis is faster in patients with fewer cardiac comorbidities and risk factors, especially if they do not have coronary heart disease. Further prospective studies are warranted to investigate the outcome of patients with slow versus fast progression of transvalvular gradient with regards to comorbidities and risk factors. KW - Valvular heart-desease KW - Prognostic impact KW - Risk-factors KW - Chronic heart-failure KW - Prevalence KW - mild KW - statins KW - therapy KW - mortality Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-227291 ER - TY - JOUR A1 - Fröhlich, M. A1 - Pinart, M. A1 - Keller, T. A1 - Reich, A. A1 - Cabieses, B. A1 - Hohmann, C. A1 - Postma, D. S. A1 - Bousquet, J. A1 - Antó, J. M. A1 - Keil, T. A1 - Roll, S. T1 - Is there a sex-shift in prevalence of allergic rhinitis and comorbid asthma from childhood to adulthood? A meta-analysis JF - Clinical and Translational Allergy N2 - Background: Allergic rhinitis and asthma as single entities affect more boys than girls in childhood but more females in adulthood. However, it is unclear if this prevalence sex-shift also occurs in allergic rhinitis and concurrent asthma. Thus, our aim was to compare sex-specifc differences in the prevalence of coexisting allergic rhinitis and asthma in childhood, adolescence and adulthood. Methods: Post-hoc analysis of systematic review with meta-analysis concerning sex-specific prevalence of allergic rhinitis. Using random-effects meta-analysis, we assessed male–female ratios for coexisting allergic rhinitis and asthma in children (0–10 years), adolescents (11–17) and adults (> 17). Electronic searches were performed using MEDLINE and EMBASE for the time period 2000–2014. We included population-based observational studies, reporting coexisting allergic rhinitis and asthma as outcome stratifed by sex. We excluded non-original or non-population-based studies, studies with only male or female participants or selective patient collectives. Results: From a total of 6539 citations, 10 studies with a total of 93,483 participants met the inclusion criteria. The male–female ratios (95% CI) for coexisting allergic rhinitis and asthma were 1.65 (1.52; 1.78) in children (N = 6 studies), 0.61 (0.51; 0.72) in adolescents (N = 2) and 1.03 (0.79; 1.35) in adults (N = 2). Male–female ratios for allergic rhinitis only were 1.25 (1.19; 1.32, N = 5) in children, 0.80 (0.71; 0.89, N = 2) in adolescents and 0.98 (0.74; 1.30, N = 2) in adults, respectively. Conclusions: The prevalence of coexisting allergic rhinitis and asthma shows a clear male predominance in childhood and seems to switch to a female predominance in adolescents. This switch was less pronounced for allergic rhinitis only. KW - Medicine KW - Allergic rhinitis KW - Asthma KW - Multimorbidity KW - Prevalence KW - Systematic review Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-172508 VL - 7 ER - TY - JOUR A1 - Walitza, Susanne A1 - Melfsen, Siebke A1 - Jans, Thomas A1 - Zellmann, Henrike A1 - Wewetzer, Christoph A1 - Warnke, Andreas T1 - Obsessive-Compulsive Disorder in Children and Adolescents JF - Deutsches Ärzteblatt International N2 - Background: Early-onset obsessive-compulsive disorder (OCD) is one of the more common mental illnesses of children and adolescents, with prevalence of 1% to 3%. Its manifestations often lead to severe impairment and to conflict in the family. In this review, we summarize the manifestations, comorbidity, pathophysiology, and course of this disease as well as current modes of diagnosis and treatment. Methods: We selectively review the relevant literature and the German-language guidelines for the diagnosis and treatment of mental illnesses in children and adolescents. Results: Obsessive-compulsive manifestations are of many types and cause severe impairment. Comorbid mental disturbances are present in as many as 70% of patients. The disease takes a chronic course in more than 40% of patients. Cognitive behavioral therapy is the treatment of first choice, followed by combination pharmacotherapy including selective serotonin reuptake inhibitors (SSRI) and then by SSRI alone. Conclusion: OCD often begins in childhood or adolescence. There are empirically based neurobiological and cognitive-behavioral models of its pathophysiology. Multiaxial diagnostic evaluation permits early diagnosis. Behavioral therapy and medications are highly effective treatments, but the disorder nonetheless takes a chronic course in a large percentage of patients. KW - Attention-deficit/hyperactivity disorder KW - Comorbidity survey replication KW - DSM-IV disorders KW - Early-onset KW - Follow-up KW - Childhood KW - Metaanalysis KW - Prevalence KW - Therapy KW - Scale Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-141214 VL - 108 IS - 11 ER - TY - JOUR A1 - Kistler, Andreas D. A1 - Siwy, Justyna A1 - Frank, Breunig A1 - Jeevaratnam, Praveen A1 - Scherl, Alexander A1 - Mullen, William A1 - Warnock, David G. A1 - Wanner, Christoph A1 - Hughes, Derralynn A. A1 - Mischak, Harald A1 - Wüthrich, Rudolf P. A1 - Serra, Andreas L. T1 - A Distinct Urinary Biomarker Pattern Characteristic of Female Fabry Patients That Mirrors Response to Enzyme Replacement Therapy JF - PLoS ONE N2 - Female patients affected by Fabry disease, an X-linked lysosomal storage disorder, exhibit a wide spectrum of symptoms, which renders diagnosis, and treatment decisions challenging. No diagnostic test, other than sequencing of the alpha-galactosidase A gene, is available and no biomarker has been proven useful to screen for the disease, predict disease course and monitor response to enzyme replacement therapy. Here, we used urine proteomic analysis based on capillary electrophoresis coupled to mass spectrometry and identified a biomarker profile in adult female Fabry patients. Urine samples were taken from 35 treatment-naive female Fabry patients and were compared to 89 age-matched healthy controls. We found a diagnostic biomarker pattern that exhibited 88.2% sensitivity and 97.8% specificity when tested in an independent validation cohort consisting of 17 treatment-naive Fabry patients and 45 controls. The model remained highly specific when applied to additional control patients with a variety of other renal, metabolic and cardiovascular diseases. Several of the 64 identified diagnostic biomarkers showed correlations with measures of disease severity. Notably, most biomarkers responded to enzyme replacement therapy, and 8 of 11 treated patients scored negative for Fabry disease in the diagnostic model. In conclusion, we defined a urinary biomarker model that seems to be of diagnostic use for Fabry disease in female patients and may be used to monitor response to enzyme replacement therapy. KW - Chronic kidney-disease KW - Onset hypertrophic cardiomyopathy KW - Mass-spectrometry KW - Alpha-galactosidase KW - Hemodialysis-patients KW - Clinical proteomics KW - Young-patients KW - Discovery KW - Globotriaosylceramide KW - Prevalence Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-133526 VL - 6 IS - 6 ER - TY - JOUR A1 - von Kries, Rüdiger A1 - Weiss, Susanne A1 - Falkenhorst, Gerhard A1 - Wirth, Stephan A1 - Kaiser, Petra A1 - Huppertz, Hans-Iko A1 - Tenenbaum, Tobias A1 - Schroten, Horst A1 - Streng, Andrea A1 - Liese, Johannes A1 - Shai, Sonu A1 - Niehues, Tim A1 - Girschick, Hermann A1 - Kuscher, Ellen A1 - Sauerbrey, Axel A1 - Peters, Jochen A1 - Wirsing von Koenig, Carl Heinz A1 - Rückinger, Simon A1 - Hampl, Walter A1 - Michel, Detlef A1 - Mertens, Thomas T1 - Post-Pandemic Seroprevalence of Pandemic Influenza A (H1N1) 2009 Infection (Swine Flu) among Children < 18 Years in Germany JF - PLoS ONE N2 - Background: We determined antibodies to the pandemic influenza A (H1N1) 2009 virus in children to assess: the incidence of (H1N1) 2009 infections in the 2009/2010 season in Germany, the proportion of subclinical infections and to compare titers in vaccinated and infected children. Methodology/Principal Findings: Eight pediatric hospitals distributed over Germany prospectively provided sera from in-or outpatients aged 1 to 17 years from April 1(st) to July 31(st) 2010. Vaccination history, recall of infections and sociodemographic factors were ascertained. Antibody titers were measured with a sensitive and specific in-house hemagglutination inhibition test (HIT) and compared to age-matched sera collected during 6 months before the onset of the pandemic in Germany. We analyzed 1420 post-pandemic and 300 pre-pandemic sera. Among unvaccinated children aged 1-4 and 5-17 years the prevalence of HI titers (>= 1:10) was 27.1% (95% CI: 23.5-31.3) and 53.5% (95% CI: 50.9-56.2) compared to 1.7% and 5.5%, respectively, for pre-pandemic sera, accounting for a serologically determined incidence of influenza A (H1N1) 2009 during the season 2009/2010 of 25,4% (95% CI : 19.3-30.5) in children aged 1-4 years and 48.0% (95% CI: 42.6-52.0) in 5-17 year old children. Of children with HI titers >= 1: 10, 25.5% (95% CI: 22.5-28.8) reported no history of any infectious disease since June 2009. Among vaccinated children, 92% (95%-CI: 87.0-96.6) of the 5-17 year old but only 47.8% (95%-CI: 33.5-66.5) of the 1-4 year old children exhibited HI titers against influenza A virus (H1N1) 2009. Conclusion: Serologically determined incidence of influenza A (H1N1) 2009 infections in children indicates high infection rates with older children (5-17 years) infected twice as often as younger children. In about a quarter of the children with HI titers after the season 2009/2010 subclinical infections must be assumed. Low HI titers in young children after vaccination with the AS03(B)-adjuvanted split virion vaccine need further scrutiny. KW - Hemagglutination inhibition KW - Vaccine KW - Age KW - Immunogenicity KW - Prevalence KW - Antibody KW - Viruses KW - England KW - Safety KW - Risk Y1 - 2011 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-141698 VL - 6 IS - 9 ER - TY - THES A1 - Walter, Martina T1 - A new methodological approach to assess drug driving – The German Smartphone Survey T1 - Ein neuer methodischer Ansatz zur Erfassung von Drogenfahrten – Die Deutsche Smartphone-Studie N2 - The aim of the present piece of work was to give information about the frequency of psychoactive substances within the German driver population and to identify preventive and promotive circumstances of drug driving. Furthermore, a new methodological approach to gather and link data about the consumption of psychoactive substances and the mobility of drug users is shown. Traditionally, roadside surveys are conducted to estimate the prevalence of drug driving within a population. By the present study, an alternative method is introduced. In total, 195 drug users (mainly cannabis users) and 100 controls out of the normal driving population were queried for four weeks about their driving and drug consumption behaviour by a questionnaire that was deployed on smartphones. The prevalences of drug driving within the sample were extrapolated into representative values. Because the subjects reported all daily activities within the study-period, it was also possible to describe situations in which the subjects decided against driving under influence. Besides, relevant previous experiences, attitudes, the approval of legal regulations, other traffic-specific parameters, social influences and personality variables were queried. So, individual factors that are associated with drug driving can be specified. The results are integrated in a model that shows dependencies of different societal, behavioural and legal variables. They can serve as major input to the discussion on drug driving and can be of practical use for rehabilitation and prevention purposes. The results can be summarised as follows: - Compared to the results of a German roadside survey from 1994, the prevalences that are found within the present study seem pretty low. This finding is discussed and possible explanations for the described trend are lined out. Furthermore, the prevalences that were calculated in the present study are compared to current data from other European countries. - The results show differences between users and controls on several variables. The differences indicate that substance use impacts on the structuring of day-to-day life. Overall, the controls’ days proceed more along a daily working routine than the users’ (e.g. less mobility at night, more mobility at rush-hour, alcohol consumption mainly at nights out). - The individual extent to which drugs are consumed differs dependent on daytime, day of the week and kind of substance. Of course, these dependencies also influence the occurrence of drug driving. Other factors of influence on drug driving are the distance, the availability of alternative modes of transport as well as the presence of female companions. - Not everybody who uses drugs drives under the influence of drugs. A striking predictor for frequent drug driving and highly intoxicated driving is a high consumption, associated with risky consumption patterns and a low subjective feeling of impairment after drug consumption. - The subjects’ attitudes towards drug driving and their beliefs about social norms largely go in line with the behaviour they engage in. Drug users have rather liberal attitudes towards drug use and driving under influence. - A possible deterrence effect of sanctioning and police enforcement and its dependence on the acceptance and awareness of the measures is delineated. - Only small effects are found when examining the objective impairment that is caused by drug use by a computer-based test battery. This result is critically discussed with regards to the operationalisation of the study groups. - Except from driving under influence, there is no evidence to suggest that DUI offenders also show problematic behaviour according to other traffic-related measures. - Parents and peers may have an influence as role models on the development of problematic behaviour. A good relationship between parents and children may have a positive impact on the development of conventional values and behaviour. - Drug use is associated with some crucial personality dimensions and drugs are often used to solve personal problems. A less precise but similar difference was found for users who commit many drives under influence compared to users who never or only sometimes drive under influence. Moreover, users marginally more often have psychological problems compared to controls. Finally, the strengths and weaknesses of the new methodological approach of data collection are discussed as well as the challenges that are faced when implementing it. All in all, it has proved to be a promising method and should serve as a standard to which future studies should aspire. N2 - Ziel der vorliegenden Arbeit war es, Informationen über das Vorkommen von Fahrten unter Substanzeinfluss in Deutschland und über Prädiktoren für das Auftreten von Drogenfahrten bereitzustellen. Des Weiteren wird ein neuer methodischer Ansatz vorgestellt, mit dem sowohl Daten über den Konsum psychoaktiver Substanzen als auch Daten über das Mobilitätsverhalten von Drogenkonsumenten erhoben und somit verknüpft werden können. Ein herkömmlicher Ansatz zur Schätzung des Vorkommens von Drogenfahrten sind Roadside Surveys. Als alternative Methode wird eine Studie beschrieben, in der 195 Drogenkonsumenten (vorwiegend Cannabiskonsumenten) sowie 100 Kontrollpersonen vier Wochen lang täglich über ein Smartphone ihr Fahr- und Konsumverhalten protokollierten. Aus der Häufigkeit von Drogenfahrten innerhalb der Stichprobe wird über eine entsprechende Gewichtung auf den tatsächlichen Anteil in der Bevölkerung geschlossen. Da von den Probanden sämtliche Aktivitäten im Erhebungszeitraum protokolliert wurden, können auch solche Situationen beschrieben werden, in denen sich die Probanden gegen eine Drogenfahrt entschieden haben. Darüber hinaus wurden Informationen über die persönliche Vorgeschichte, relevante Einstellungen, die Akzeptanz gesetzlicher Regelungen, weitere verkehrsrelevante Auffälligkeiten, soziale Einflüsse sowie Informationen über Persönlichkeitsmerkmale eingeholt. Hierdurch können Umstände und Hintergründe, unter denen Drogenfahrten stattfinden, spezifiziert werden. Die Ergebnisse werden in ein Model integriert, das Abhängigkeiten zwischen gesellschaftlichen Variablen, Verhaltensparametern und gesetzlichen Gegebenheiten aufzeigt. Die Studie liefert aufschlussreiche Befunde, die sowohl die wissenschaftliche Diskussion um Drogenfahrten anregen als auch von praktischem Nutzen für Rehabilitations- und Präventionsmaßnahmen sein können. Die Ergebnisse lassen sich wie folgt zusammenfassen: - Verglichen mit den Ergebnissen einer deutschen Roadside Survey aus dem Jahr 1994 fallen die hier kalkulierten Prävalenzen für Drogenfahrten in Deutschland recht gering aus. Der Befund wird diskutiert und es werden mögliche Gründe für den beschriebenen Trend aufgeführt. Außerdem werden die berechneten Werte mit aktuellen Vergleichsdaten aus anderen europäischen Ländern verglichen. - Der Konsum von Drogen hat gewisse Auswirkungen auf die Gestaltung des Alltags einer Person. Insgesamt scheinen Kontrollpersonen im Vergleich zu Drogenkonsumenten eher einem geregelten Arbeitsalltag nachzugehen (z. B. weniger Mobilität in der Nacht, mehr Mobilität zu Zeiten des allgemeinen Berufsverkehrs, Alkoholkonsum reduziert auf Ausgehzeiten). - Das Ausmaß des individuellen Drogenkonsums variiert in Abhängigkeit von Tageszeit, Wochentag und Art der Substanz. Natürlich wirken sich diese Abhängigkeiten ebenso auf das Auftreten von Drogenfahrten aus. Weitere situative Einflussfaktoren für Drogenfahrten sind die Länge der zurückzulegenden Strecke, die Verfügbarkeit alternativer Fortbewegungsmittel sowie weibliche Begleitpersonen. - Nicht jeder, der Drogen konsumiert, fährt auch unter Drogeneinfluss Auto. Als wesentlicher Prädiktor für häufige Drogenfahrten und hohe Substanzkonzentrationen im Blut während der Fahrt kann ein hoher Konsum genannt werden. Damit verbunden sind riskante Konsummuster sowie eine geringe subjektive Beeinträchtigung nach dem Konsum von Drogen. - Die Einstellung der Versuchspersonen zu Drogenfahrten sowie ihre Annahmen über soziale Normen stimmen zum großen Teil mit ihrem Verhalten überein. Drogenkonsumenten haben eher liberale Einstellungen zu Drogenkonsum und Drogenfahrten. - Eine mögliche abschreckende Wirkung von Sanktionen und polizeilichen Überwachungmaßnahmen und ihre Abhängigkeit von der Akzeptanz und der subjektiven Wahrnehmung der Maßnahmen wird beschrieben. - Eine objektive Leistungsbeeinträchtigung durch die Wirkung von Drogen mittels einer computerbasierten Testbatterie kann nur in geringem Maße nachgewiesen werden. Das Ergebnis wird hinsichtlich der Operationalisierung der untersuchten Gruppen kritisch diskutiert. - Es finden sich keine Hinweise dafür, dass Drogenfahrer, außer durch die Drogenfahrten an sich, auch sonst im Verkehr auffällig werden. - Eltern und Freunde scheinen als Rollenvorbilder Einfluss auf die Entwicklung von Problemverhalten zu nehmen. Eine gute Eltern-Kind-Beziehung wirkt sich positiv auf die Entwicklung konventioneller Werte und Verhalten aus. - Drogenkonsum ist mit einigen wesentlichen Persönlichkeitsmerkmalen assoziiert und Konsumenten weisen etwas häufiger psychische Probleme auf als Kontrollpersonen. Abschließend werden Stärken und Schwächen der neuen Methode diskutiert sowie besondere Anforderungen aufgeführt, die bei der Durchführung zu beachten sind. Insgesamt erwies sich die Methode als vielversprechend und sollte als Standard in künftigen Studien weiterentwickelt werden. KW - Verkehrspsychologie KW - Rauschgift KW - Alkohol KW - Fahren KW - Ambulantes Assessment KW - Ecological Momentary Assessment KW - Elektronisches Tagebuch KW - Drogen KW - Prävalenz KW - Prädiktor KW - Smartphone KW - Drugs KW - Alcohol KW - Driving KW - Prevalence KW - Predictors KW - Ambulatory Assessment KW - Ecological Momentary Assessment KW - Electronic diary KW - Mobile technology Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-75283 ER -