TY  - JOUR
A1  - Schlauersbach, Jonas
A1  - Hanio, Simon
A1  - Lenz, Bettina
A1  - Vemulapalli, Sahithya P. B.
A1  - Griesinger, Christian
A1  - Pöppler, Ann-Christin
A1  - Harlacher, Cornelius
A1  - Galli, Bruno
A1  - Meinel, Lorenz
T1  - Leveraging bile solubilization of poorly water-soluble drugs by rational polymer selection
JF  - Journal of Controlled Release
N2  - Poorly water-soluble drugs frequently solubilize into bile colloids and this natural mechanism is key for efficient bioavailability. We tested the impact of pharmaceutical polymers on this solubilization interplay using proton nuclear magnetic resonance spectroscopy, dynamic light scattering, and by assessing the flux across model membranes. Eudragit E, Soluplus, and a therapeutically used model polymer, Colesevelam, impacted the bile-colloidal geometry and molecular interaction. These polymer-induced changes reduced the flux of poorly water-soluble and bile interacting drugs (Perphenazine, Imatinib) but did not impact the flux of bile non-interacting Metoprolol. Non-bile interacting polymers (Kollidon VA 64, HPMC-AS) neither impacted the flux of colloid-interacting nor colloid-non-interacting drugs. These insights into the drug substance/polymer/bile colloid interplay potentially point towards a practical optimization parameter steering formulations to efficient bile-solubilization by rational polymer selection.
KW  - polymer drug interaction
KW  - flux
KW  - bile salt
KW  - simulated intestinal fluid
KW  - colloid
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-296957
VL  - 330
ET  - Accepted Version
ER  - 
TY  - JOUR
A1  - Timmermans, Wim J.
A1  - van der Tol, Christiaan
A1  - Timmermans, Joris
A1  - Ucer, Murat
A1  - Chen, Xuelong
A1  - Alonso, Luis
A1  - Moreno, Jose
A1  - Carrara, Arnaud
A1  - Lopez, Ramon
A1  - Fernando de la Cruz, Tercero
A1  - Corcoles, Horacio L.
A1  - de Miguel, Eduardo
A1  - Sanchez, Jose A. G.
A1  - Perez, Irene
A1  - Belen, Perez
A1  - Munoz, Juan-Carlos J.
A1  - Skokovic, Drazen
A1  - Sobrino, Jose
A1  - Soria, Guillem
A1  - MacArthur, Alasdair
A1  - Vescovo, Loris
A1  - Reusen, Ils
A1  - Andreu, Ana
A1  - Burkart, Andreas
A1  - Cilia, Chiara
A1  - Contreras, Sergio
A1  - Corbari, Chiara
A1  - Calleja, Javier F.
A1  - Guzinski, Radoslaw
A1  - Hellmann, Christine
A1  - Herrmann, Ittai
A1  - Kerr, Gregoire
A1  - Lazar, Adina-Laura
A1  - Leutner, Benjamin
A1  - Mendiguren, Gorka
A1  - Nasilowska, Sylwia
A1  - Nieto, Hector
A1  - Pachego-Labrador, Javier
A1  - Pulanekar, Survana
A1  - Raj, Rahul
A1  - Schikling, Anke
A1  - Siegmann, Bastian
A1  - von Bueren, Stefanie
A1  - Su, Zhongbo (Bob)
T1  - An Overview of the Regional Experiments for Land-atmosphere Exchanges 2012 (REFLEX 2012) Campaign
JF  - Acta Geophysica
N2  - The REFLEX 2012 campaign was initiated as part of a training course on the organization of an airborne campaign to support advancement of the understanding of land-atmosphere interaction processes. This article describes the campaign, its objectives and observations, remote as well as in situ. The observations took place at the experimental Las Tiesas farm in an agricultural area in the south of Spain. During the period of ten days, measurements were made to capture the main processes controlling the local and regional land-atmosphere exchanges. Apart from multi-temporal, multi-directional and multi-spatial space-borne and airborne observations, measurements of the local meteorology, energy fluxes, soil temperature profiles, soil moisture profiles, surface temperature, canopy structure as well as leaf-level measurements were carried out. Additional thermo-dynamical monitoring took place at selected sites. After presenting the different types of measurements, some examples are given to illustrate the potential of the observations made.
KW  - multi scale heterogeneity
KW  - quantitative remote sensing
KW  - remote
KW  - evapotranspiration
KW  - validation
KW  - issues
KW  - energy
KW  - models
KW  - water
KW  - flux
KW  - land-atmosphere interaction
KW  - turbulence
KW  - calibration and validation
Y1  - 2015
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-136491
VL  - 63
IS  - 6
ER  -