TY  - JOUR
A1  - Grotemeyer, Alexander
A1  - McFleder, Rhonda Leah
A1  - Wu, Jingjing
A1  - Wischhusen, Jörg
A1  - Ip, Chi Wang
T1  - Neuroinflammation in Parkinson’s disease – putative pathomechanisms and targets for disease-modification
JF  - Frontiers in Immunology
N2  - Parkinson’s disease (PD) is a progressive and debilitating chronic disease that affects more than six million people worldwide, with rising prevalence. The hallmarks of PD are motor deficits, the spreading of pathological α-synuclein clusters in the central nervous system, and neuroinflammatory processes. PD is treated symptomatically, as no causally-acting drug or procedure has been successfully established for clinical use. Various pathways contributing to dopaminergic neuron loss in PD have been investigated and described to interact with the innate and adaptive immune system. We discuss the possible contribution of interconnected pathways related to the immune response, focusing on the pathophysiology and neurodegeneration of PD. In addition, we provide an overview of clinical trials targeting neuroinflammation in PD.
KW  - Parkinson’s disease
KW  - neuroinflammation
KW  - T cells
KW  - microglia
KW  - neurodegeneration
KW  - animal models
KW  - inflammatory cascades
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-274665
SN  - 1664-3224
VL  - 13
ER  - 
TY  - JOUR
A1  - Albert-Weißenberger, Christiane
A1  - Várrallyay, Csanád
A1  - Raslan, Furat
A1  - Kleinschnitz, Christoph
A1  - Sirén, Anna-Leena
T1  - An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice
N2  - Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI.
KW  - Medizin
KW  - closed head injury
KW  - traumatic brain injury
KW  - neurobehavioural deficits
KW  - astrocyte
KW  - microglia
KW  - neurons
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-75368
ER  -