TY  - JOUR
A1  - Stöber, Gerald
A1  - Franzek, E.
A1  - Beckmann, H.
T1  - The role of maternal infectious diseases during pregnancy in the etiology of schizophrenia in offspring
N2  - In 55 chronic schizophrenics, the occurrence of infectious diseases during their mothers' pregnancies was investigated. Different psychiatrie diagnostic systems were compared. Infections were reported by the mothers of familial and sporadic DSM I1I-R schizophrenics in equal proportion. However, applying Leonhard's classification, the frequency of infections was found to be significantly increased in 'systematic' schizophrenia (mainly exogenously induced in the view of Leonhard) compared to 'unsystematic' schizophrenia (mainly genetically determined according to Leonhard's findings). Most of the infections occurred during the second trimester (nine out of 13). Thus, in the 'systematic' forms of schizophrenia (low genetic loading), maternal infections in this crucial period of neurodevelopment would appear to be important causative factors in the cytoarchitectural deviance detected in the central nervous system of schizophrenics.
KW  - Psychiatrie
KW  - maternal infection
KW  - pregnancy
KW  - schizophrenia
KW  - familial-sporadic concept
KW  - Leonhard classification
Y1  - 1992
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82216
ER  -