TY  - JOUR
A1  - Paul, Mila M.
A1  - Mieden, Hannah J.
A1  - Lefering, Rolf
A1  - Kupczyk, Eva K.
A1  - Jordan, Martin C.
A1  - Gilbert, Fabian
A1  - Meffert, Rainer H.
A1  - Sirén, Anna-Leena
A1  - Hoelscher-Doht, Stefanie
T1  - Impact of a femoral fracture on outcome after traumatic brain injury — a matched-pair analysis of the TraumaRegister DGU\(^®\)
JF  - Journal of Clinical Medicine
N2  - Traumatic brain injury (TBI) is the leading cause of death and disability in polytrauma and is often accompanied by concomitant injuries. We conducted a retrospective matched-pair analysis of data from a 10-year period from the multicenter database TraumaRegister DGU\(^®\) to analyze the impact of a concomitant femoral fracture on the outcome of TBI patients. A total of 4508 patients with moderate to critical TBI were included and matched by severity of TBI, American Society of Anesthesiologists (ASA) risk classification, initial Glasgow Coma Scale (GCS), age, and sex. Patients who suffered combined TBI and femoral fracture showed increased mortality and worse outcome at the time of discharge, a higher chance of multi-organ failure, and a rate of neurosurgical intervention. Especially those with moderate TBI showed enhanced in-hospital mortality when presenting with a concomitant femoral fracture (p = 0.037). The choice of fracture treatment (damage control orthopedics vs. early total care) did not impact mortality. In summary, patients with combined TBI and femoral fracture have higher mortality, more in-hospital complications, an increased need for neurosurgical intervention, and inferior outcome compared to patients with TBI solely. More investigations are needed to decipher the pathophysiological consequences of a long-bone fracture on the outcome after TBI.
KW  - traumatic brain injury
KW  - femoral fracture
KW  - damage control orthopedics
KW  - mortality
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-319363
SN  - 2077-0383
VL  - 12
IS  - 11
ER  -