TY  - JOUR
A1  - Schecklmann, Martin
A1  - Giani, Anette
A1  - Tupak, Sara
A1  - Langguth, Berthold
A1  - Raab, Vincent
A1  - Polak, Thomas
A1  - Varallyay, Csanad
A1  - Harnisch, Wilma
A1  - Herrmann, Martin J.
A1  - Fallgatter, Andreas J.
T1  - Functional Near-Infrared Spectroscopy to Probe State- and Trait-Like Conditions in Chronic Tinnitus: A Proof-of-Principle Study
JF  - Neural Plasticity
N2  - Objective. Several neuroscience tools showed the involvement of auditory cortex in chronic tinnitus. In this proof-of-principle study we probed the capability of functional near-infrared spectroscopy (fNIRS) for the measurement of brain oxygenation in auditory cortex in dependence from chronic tinnitus and from intervention with transcranial magnetic stimulation. Methods. Twenty-three patients received continuous theta burst stimulation over the left primary auditory cortex in a randomized sham-controlled neuronavigated trial (verum = 12; placebo = 11). Before and after treatment, sound-evoked brain oxygenation in temporal areas was measured with fNIRS. Brain oxygenation was measured once in healthy controls (n = 12). Results. Sound-evoked activity in right temporal areas was increased in the patients in contrast to healthy controls. Left-sided temporal activity under the stimulated area changed over the course of the trial; high baseline oxygenation was reduced and vice versa. Conclusions. By demonstrating that rTMS interacts with auditory evoked brain activity, our results confirm earlier electrophysiological findings and indicate the sensitivity of fNIRS for detecting rTMS induced changes in brain activity. Moreover, our findings of trait-and state-related oxygenation changes indicate the potential of fNIRS for the investigation of tinnitus pathophysiology and treatment response.
KW  - transcranial magnetic stimulation
KW  - positron-emission-tomography
KW  - auditory cortex
KW  - FNIRS
KW  - RTMS
KW  - neural activity
KW  - FMRI
KW  - brain
KW  - activation
KW  - humans
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-117801
SN  - 1687-5443
IS  - 894203
ER  -