TY  - JOUR
A1  - Schneider, Wolfgang
A1  - Treiber, Bernhard
T1  - Classroom differences in the determination of achievement changes
N2  - This study addresses three themes that recur in the research on student achievement: (a) developmental modeling ofintraindividual changes in achievement over time; (b) examination of the differences among subgroups within a classroom in the determinants of achievement; (c) description of the interactions among instructional variables in determining achievement differences. Eight classrooms were preselected on the basis of their widely differing slopes obtained in a regression analysis of pre- and posttest achievement scores. Mathematics achievement differences among sixth graders were analyzed in a four-wave design and explained by aptitude and instructional variables in a structural equation framework provided by LISREL. The results demonstrate the local nature of achievement models in that neither their measurement nor structural components proved generalizable across both groups of classrooms. Mention is also made, however, of technical problems and analytical ambiguities in the interpretation of these results.
KW  - Psychologie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61991
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Strecker, M.
A1  - Lambrecht, G.
A1  - Moser, U.
A1  - Mutschler, E.
T1  - Bioisosterer C/Si-Austausch bei Parasympatholytika vom Typ des Pridinols
T1  - Bioisosterie C/Si Exchange in Parasympatholytia of tbe Pridinol Type
N2  - Die Synthese der (2·Aminoethyl)diphenylsilanole 3b und 4b wird beschrieben. Die parasympatholytischen Eigenschaften der CISi-Paare la/lb-4a/4b wurden am isolierten Ileum des Meerschweinchens untersucht. In allen Fällen führt der C/Si-Austausch zu einer Zunahme der Affinität zum Muskarin-Rezeptor.
N2  - The synthesis of the (2·aminoethyl)diphenylsilanols 3b and 4b is described. The Q'Si pairs lallb-4a/4b were tested for atropine-like activity on the isolated guinea-pig ileum. In all cases the C/Si exchange Ieads to an increased affinity for the muscarine-sensitive acetylcholine receptor.
KW  - Anorganische Chemie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63766
ER  - 
TY  - JOUR
A1  - Lutz, Werner K.
A1  - Büsser, M. T.
A1  - Sagelsdorff, P.
T1  - Potency of carcinogens derived from covalent DNA binding and stimulation of DNA synthesis in rat liver
N2  - ~n order to investigate the role of the stimu~ation of ceU division for the initiation (and possi:bly promotion) of live·r tumors by chemical carcinogens, the incorporation of radiolabeUed thymidine into liver DNA was dete:rmined in male rats. Single doses of various level!s of af.latoxin 81, benzidine and carbon tetrachloride (aU known to be genotoxic via DNA binding} did not affect cell division, whereas several hepatoca:rcinogens known not to bind to DNA (alphaHCH, dofibrate, and 2,3;7,8-t!etrachlorodiibenzo~p~dioxin) gave rise to a dosedependent stimulation of Ii ver DNA synthesis within 24 h. An equation combining the infl.uences of mitotic stimu:lation, expressed as dose required to double the contro~ Ievei of DNA synthesis, and DNA binding potency, exp:ressed as t.he Covalent Binding Index, correliated weil with the cardnogenk potency for both dasses of hepatocardnogens.
KW  - Toxikologie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61026
ER  - 
TY  - JOUR
A1  - Huber, K. W.
A1  - Lutz, Werner K.
T1  - Methylation of DNA by incubation with methylamine and nitrite
N2  - DNA was incubated in septum-closed reaction vials with [\(^{14}\)C]methylamine and nitrite. The DNA was purified, hydrolysed with hydrochloric acid, and the purines were analysed by h.p.l.c. 7-Methylguanine was detectable as a result of DN A methylation in experiments perfonned in 100 mM acetate at pH 4. Using different concentrations of amine and nitrite a first order reaction for total amine and a second order for total nilrite could be shown. A study on the pH dependence using 100 mM malonate buffer, pH 2.0-6.0, revealed a maximum rate at pH 3.5, with steep slopes above and below this pH value, in agreement with a mathematical analysis of the reaction equations. The data show that the alkylating agent fonned spontaneously by nitrosation and deamination of a primary amine has a long enough lifetime to react with DNA in vitro. Using the reactioil orders established here, an extrapolation to lower concentrations found in the stomach can now be perfonned. Future in vivo experiments on the methylation of gastro-intestinal DNA then would show to what extent DNA in a cell is protected from alkylation.
KW  - Toxikologie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61011
ER  - 
TY  - JOUR
A1  - Däniken, A. von
A1  - Lutz, Werner K.
A1  - Jäckh, R.
A1  - Schlatter, C.
T1  - Investigation of the potential for binding of Di(2-ethylhexyl) phthalate (DEHP) and Di(2-ethylhexyl) adipate (DEHA) to liver DNA in vivo
N2  - Investigation of the Potential for Binding of Di(2-ethylhexyl) Phthalate (DEHP) and Di(2- ethylhexyl) Adipate (DEHA) to Liver DNA in Vivo. VON DÄNIKEN, A., LUTZ, W. K., JÄCKH, R., AND ScHLATTER, C. (1984). Toxico/. App/. Pharmaco/. 73, 373-387. It was the aim oftbis investigation to determine whether covalent binding of di(2-ethylhexyl) phthalate (DEHP) to rat liver DNA and of di(2-ethylhexyl) adipate (DEHA) to mouse liver DNA could be a mechanism of action contributing to the observed induction of liver tumors after lifetime feeding of the respective rodent species with high doses of DEHP and DEHA. For this purpose, DEHP and DEHA radiolabeled in different parts of the molecule were administered orally to female rats and mice, respectively, with or witbout pretreatment for 4 weeks with 1% unlabeled compound in the diet. Liver DNA was isolated after 16 hr and analyzed for radioactivity. The data were converted to a covalent binding index, CBI = (micromoles of substance bound per mole of DNA nucleotides)/(millimoles of substance applied per kilogram body weight), in order to allow a quantitative comparison also with other carcinogens and noncarcinogens. Administration of [\(^{14}\)H]carboxylate-labeled DEHP to rats resulted in no measurable DNA radioactivity. The Iimit of detection, CBI < 0.02 was about 100 times below the CBI of compounds where an observable tumor-inducing potential could be due to genotoxicity. With [\(^{14}\)C]- and [\(^{3}\)H]DEHP labeled in the alcohol moiety, radioactivity was clearly measurable in rat liver DNA. HPLC analysis of enzyme-degraded or acid-hydrolyzed DNA revealed that the natural nucleosides or purine bases were radiolabeled whereas no radioactivity was detectable in those fractions where tbe carcinogenmodified nucleoside or base adducts are expected. The respective Iimits of detection were at 0.07 and 0.04 CBI units for the \(^{14}\)C and \(^{3}\)H Iabels, respectively. The experiments with [\(^{14}\)C]- and [\(^{3}\)H]DEHA, labeled in the alcobol moiety and administered to mice, revealed aminute radioactivity of <50 dpm/mg liver DNA, too little to allow a nucleoside analysis to determine that fraction of the radioactivity which bad been incorporated via biosynthesis. Expressed in the CBI units, values of 0.05 to 0.15 for \(^{14}\)C and 0.01 to 0.12 for \(^{3}\)H resulted. Determination of the level· of \(^{14}\)C02 expiration revealed a linear correlation with the speciftc activity of DNA. Experiments with 2-ethyl[ 1-\(^{14}\)C]hexanol perfonned with both rats and mice allowed the conclusion tbat most if not all DEHA radioactivity in mouse liver DNA was due to biosynthetic incorporation. A maximum possible true DNA binding by DEHA must be below CBI 0.01. Pretreatment of the animals witb unlabeled compound bad no effect on the DNA radioactivities in either species. The present negative data, in conjunction witb other negative short-term tests for mutagenicity, strongly indicate that covalent interaction with DNA is highly unlikely to be the mode of tumorigenic action of DEHP and DEHA in rodents.
KW  - Toxikologie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61004
ER  - 
TY  - JOUR
A1  - Caviezel, M.
A1  - Lutz, Werner K.
A1  - Minini, U.
A1  - Schlatter, C.
T1  - Interaction of estrone and estradiol with DNA and protein of liver and kidney in rat and hamster in vivo and in vitro
N2  - (6,7-\(^3\)H] Estrone (E) and [6,7-\(^3\)H]estradiol-17ß (E\(_2\)) have been synthesized by reduction of 6-dehydroestrone and 6-dehydroestradiol with tritium gas. Tritiated E and E\(_2\) were administered by oral gavage to female rats and to male and female hamsters on a dose level of about 300 \(\mu\)g/kg (54 mCi/kg). After 8 h, the liver was excised from the rats; liver and kidneys were taken from the hamsters. DNA was purified either directly from an organ homogenate or via chromatin. The radioactivity in the DNA was expressed in the units of the Covalent Binding Index, CBI = (\(\mu\)mol chemical bound per mol Similar considerations can be made for the liver where any true covalent DNA binding must be below a Ievel of 0.01. It is concluded that an observable tumor induction by estrone or estradiol is unlikely to be due to DNA binding. DNA-P)/(mmol chemical administered per kg b.w.). Rat liver DNA isolated via chromatin exhibited the very low values of 0.08 and 0.09 for E and E\(_2\) respectively. The respective figures in hamster liver were 0.08 and 0.11 in females and 0.21 and 0.18 in the males. DNA isolated from the kidney revealed a detectable radioactivity only in the female, with values of 0.03 and 0.05 for E and E\(_2\) respectively. The values for male hamster kidney were < 0.01 for both hormones. The minute radioactivity detectable in the DNA samples does not represent covalent binding to DNA, however, as indicated by' two sets of control experiments. (A) Analysis by HPLC of the nucleosides prepared by enzyme digest of liver DNA isolated directly or via chromatin did not reveal any consistent peak which could have been attributed to a nucleoside-steroid adduct. (B) All DNA radioactivity could be due to protein contaminations, because the specific activity of chromatin protein was determined to be more than 3 ,000 tim es high er than of DNA. The high affinity of the hormone to protein was also demonstrated by in vitro incubations, where it could be shown that the specific activity of DNA and protein was essentially proportional to the concentration of radiolabelled hormone in the organ homogenate, regardless of whether the animal was treated or whether the hormone was added in vitro to the homogenate. Carcinogens acting by covalent DNA binding can be classified according to potency on the basis of the Covalent Binding Index. Values of 10\(^3\)-10\(^4\) have been found for potent, 10\(^2\) for moderate, and 1-10 for weak carcinogens. Since estrone is moderately carcinogenic for the kidney of the male hamster, a CBI of about 100 would be expected. The actually measured Iimit of detection of 0.01 places covalent DNA binding among the highly unlikely mechanisms of action.
KW  - Toxikologie
KW  - Estrogen
KW  - Hormone
KW  - Carcinogenesis
KW  - DNA binding
KW  - Protein binding
KW  - Estrone
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-60995
ER  - 
TY  - JOUR
A1  - Huber, K. W.
A1  - Lutz, Werner K.
T1  - Methylation of DNA in stomach and small intestine of rats after oral administration of methylamine and nitrite
N2  - Young adult male Sprague-Dawley rats were given 30 \(\mu\)mol/kg body weight [\(^{14}\)C]methylamine hydrochloride and 700 \(\mu\)mol/ kg body weight sodium nilrite by oral gavage. DNA isolated from the stomach and from the first 15 cm of the smaß intestine was methylated, containing 7-methylguanine (7mG) at a level of one 7mG molecule per 5x10\8^6\) and lx10\(^7\) nucleotides, respectively. No 7mG was found fn the liver at a limit of detection of one 7mG molecule per 2xl0\(^8\) nucleotides. ln a second experiment, the excised stomachs were incubated with deoxyribonuclease before the isolation of the DNA in order to degrade DNA in the Iumen and in the uppermost lining cells. This treatment resulted in a 30% decrease in the yield of DNA and a 90% reduction in the level of 7mG formation. The results show that nitrosation of a primary alkylamine yields a precursor of an alkylating agent which has a long enough lifetime to diffuse towards and react with intracellular DNA. A correlation of DNA methylation in the stomach with the corresponding tumor formation by the methylating carcinogen N-methyi-N'-nitro-N-nitroso-guanidine was used to estimate the roJe of DNA damage resulting from endogenous nitrosation of dietary methylamine in man. It was concluded that the risk resulting from this single amine must be negligible bot that a similar evaluation of other primary amines is required before the over-aU role of primary amine nitrosation in the etiology of human gastric cancer can be assessed.
KW  - Toxikologie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-60984
ER  - 
TY  - JOUR
A1  - Gessler, Manfred
A1  - Barnekow, Angelika
T1  - Differential expression of the cellular oncogenes c-src and c-yes in embryonal and adult chicken tissues
N2  - The cellular onc-genes c-src and c-yes are expressed very differently during chicken embryonic development. The c-src mRNA and its translational product are detectable at high levels in brain extracts of chicken embryos and adult chickens, whereas muscle extracts show an age-dependent decrease in the amounts of c-src-specific mRNA and pp60<sup>c-src</sup> kinase activity. In contrast, the Ievels of c-yes mRNA in brain, heart, and muscle are relatively low in early embryonic stages and increase later on to values comparable to those found for liver, while in adult animals the pattern of c-yes expression is similar to that of the c-src gene. From the close correlation between the Ievels of pp60<sup>c-src</sup>, its enzymatic activity, and its corresponding mRNA at a given stage of development and in given tissues, it appears that the expression of pp60<sup>c-src</sup> is primarily controlled at the level of transcription. It is suggested that because of the different patterns of expression, the two cellular oncogenes, c-src and c-yes, play different roles in cell proliferation during early embryonic stages as weil as in ensuing differentiation processes.
KW  - Biochemie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59289
ER  - 
TY  - JOUR
A1  - Christl, Manfred
A1  - Leininger, H.
A1  - Kemmer, P.
T1  - Über das cis-Glycol und das Epoxid des Benzvalens
N2  - No abstract available
KW  - Organische Chemie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58174
ER  - 
TY  - JOUR
A1  - Christl, Manfred
A1  - Lang, R.
A1  - Reimann, W.
A1  - Irngartinger, H.
T1  - Darstellung und Röntgenstrukturanalyse des Diels-Alder-Addukts von 4-Phenyl-4H-1,2,4-triazol-3,5-dion an Octavalen
N2  - No abstract available
KW  - Organische Chemie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58162
ER  - 
TY  - JOUR
A1  - Schenk, Wolfdieter A.
A1  - Leissner, Johanna
A1  - Burschka, Christian
T1  - Stabilisierung von Schwefelmonoxid durch Koordination an Übergangsmetalle
T1  - Stabilization of sulfur monoxide by coordination on transition metals
N2  - No abstract available
KW  - Anorganische Chemie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-57848
ER  - 
TY  - JOUR
A1  - Schneider-Schaulies, Jürgen
A1  - Knauer, R.
A1  - Hünig, T.
A1  - Schimpl, A.
A1  - Wecker, E.
T1  - Induction of c-onc expression in polyclonally activated mouse lymphocytes
N2  - No abstract available
KW  - Lymphozyt
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-54784
ER  - 
TY  - JOUR
A1  - Sirén, Anna-Leena
A1  - Paakkari, I.
T1  - Cardiovascular effects of TRH i.c.v. in conscious rats
N2  - In addition to the endocrine effects, the thyrotropin releasing hormone (TRH) is known to induce dose-dependent increases in blood pressure and heart rate after intracerebroventricular (i.c.v.) administration in urethane-anaesthetised rats (1, 2). The a~ of the present study was to investigate whether TRH has similar effects in conscious rats of various strains i.e. spontaneously hypertensive rats (SHR), normotensive Wistar-Kyoto (WKY) and Wistar (NR) rats.
KW  - Medizin
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-49071
ER  - 
TY  - JOUR
A1  - Wieber, Markus
A1  - Wirth, Dieter
A1  - Burschka, Christian
T1  - Synthese und Struktur einiger Methyl(dicarboxilato)stibane
T1  - Syntheses and structure of Some Methyl(dicarboxilato)stibanes
N2  - No abstract available
KW  - Chemie
KW  - Methyldiethoxistibane
KW  - Methyl(maleato)stibane
KW  - Methyl(phthalato)stibane
KW  - X-Ray
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46741
ER  - 
TY  - CHAP
A1  - Weinert, F. E.
A1  - Knopf, Monika
A1  - Körkel, J.
A1  - Schneider, Wolfgang
A1  - Vogel, K.
A1  - Wetzel, M.
T1  - Die Entwicklung einiger Gedächtnisleistungen bei Kindern und älteren Erwachsenen in Abhängigkeit von kognitiven, metakognitiven und motivationalen Einflußfaktoren
N2  - No abstract available
KW  - Psychologie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50458
ER  - 
TY  - JOUR
A1  - Ulrichs, Karin
A1  - Schang, T.
A1  - Keller, R.
A1  - Müller-Ruchholtz, W.
T1  - Reactivity of pancreas islet cells with antisera of known specificity
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45466
ER  - 
TY  - JOUR
A1  - Ulrichs, Karin
A1  - Yu, MY
A1  - Duncker, D.
A1  - Müller-Ruchholtz, W.
T1  - Immunosuppression by cytostatic drugs?
N2  - In the present study, an attempt was made to characterize the immunomodulating abilities of the cytostatic drugs cydophosphamide, ifosfamide, vinblastine, vincristine, procarbazine, dacarbazine, 6-mercaptopurine, methotrexate, 5-f/uor-uracil and adriamycine in a defined experimental model. Varying combinations of drug plus transplantation alloantigen, (C3H-lymphocytes) were injected into Balb/c mice at different time intervals in vivo. The resulting T-effector cell reactivity was determined in vitro with the microcytotoxicity assay on day + 5 for primary (r) and day + 7 for secondary (2°) sensitized mice. According to the type of drug (alkylating agent vs. vinca alkaloid vs. antimetabolite vs. cytostatic antibiotic), the dosage (20% LD50 vs. 60% LD50), the state of sensitization (r vs. 2° sensitized recipients), and the time of drug application in relation to the antigen treatment on day 0 (in varying steps from day -6 to day +4), so-called "pharmaconantigen- variation-effects" (PA VE) were established for each of the investigated drugs in form of reaction profiles. The results were as folIows: (1) For almost alt substances, characteristic reaction profiles involving immunostimulation and/or immunosuppression could be established. Similarities in the profiles of different substances made it possible to classify the drugs according to different reaction types. The reaction type however is not definitely correlated to the biochemical mechanism of drug action. (2) The PA VE are decisively inf/uenced by so me of the biological parameters, such as the time of drug application in relation to the antigen treatment and the state of sensitization but relatively !ittle by the dosage of the drug. (3) Considering the different processes occurring du ring primary and secondary immune responses, the PAVE may give hints for a distinct manipulation of the immunoregulation and thus information on the immunobiological mechanism of drug action.
KW  - Immunologie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45574
ER  - 
TY  - JOUR
A1  - Werner, H.
A1  - Otto, H.
A1  - Tri, Ngo Khac
A1  - Burschka, Christian
T1  - Synthese und Eigenschaften neuer Kupfer- und Gold- Komplexe des Typs C\(_5\)H\(_5\)MPR\(_3\), C\(_5\)Me\(_5\)MPR\(_3\) und R"C\(_2\)MPR\(_3\)(M=Cu,Au)sowie die Kristallstruktur von C\(_5\)H\(_5\)AuPPr\(_3\)
N2  - No abstract available
KW  - Chemie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46666
ER  - 
TY  - JOUR
A1  - Werner, Helmut
A1  - Werner, Reiner
A1  - Burschka, Christian
T1  - Aromaten(phosphan)metall-Komplexe, V: zur Addition von Carbanionen an (Benzol)ruthenium(II)- und -osmium(II)-Komplexe. Kristall- und Molekülstruktur von (exo-6-n-C4H9-Pi5-C6H6)OsI(PMe3)2
N2  - No abstract available
KW  - Chemie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46652
ER  - 
TY  - JOUR
A1  - Werner, H.
A1  - Kletzin, H.
A1  - Burschka, Christian
T1  - Aromaten(Phosphan)Metall-Komplexe: VIII. Syntese und Struktur eines Diaromatenruthenium-Komplexes mit Pi-gebundenem Triphenylphosphan-Liganden
N2  - No abstract available
KW  - Chemie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46627
ER  - 
TY  - JOUR
A1  - Hoffmann, Gerhard G.
A1  - Burschka, Christian
T1  - Darstellung und Eigenschaften von Diphenylalkylthio- und Diphenylarylthio-Gallanen : Kristallstruktur von Diphenylethylthiogallan
N2  - Triphenylgallan reagiert mit Alkyl- bzw. Arylthiolen unter Bildung der entsprechenden Diphenylalkyl- und Diphenylarylthiogallane. Spektren sowie einige physikalische und chemische Eigenschaften der neuen Verbindungen werden mitgeteilt. Die Ergebnisse der Röntgenstrukturuntersuchung von Diphenylethylthiogallan werden diskutiert.
N2  - Triphenylgallane reacts with alkyl- and aryl-thiols, respectively, with formation of the corresponding diphenylalkyl- and diphenylaryl-thiogallanes. Spectra and some physical and chemical properties of the new compounds are given. The results of the X-ray structure determination of diphenylethylthiogallane are discussed.
KW  - Chemie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-46612
ER  - 
TY  - CHAP
A1  - Krüger, Hans-Peter
T1  - Was ist Sprechen? - objektive Registrierung des Sprechverhaltens im Alltag mit dem Logoport
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41266
ER  - 
TY  - CHAP
A1  - Ellgring, Johann Heinrich
T1  - The study of nonverbal behavior and its applications: State of the art in Europe
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42997
ER  - 
TY  - CHAP
A1  - Klos, Thomas
A1  - Ellgring, Johann Heinrich
T1  - Sprechgeschwindigkeit und Sprechpausen von Depressiven
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41977
ER  - 
TY  - CHAP
A1  - Warburg, M. R.
A1  - Linsenmair, Karl Eduard
A1  - Bercovitz, K.
T1  - The effect of climate on the distribution and abundance of isopods
N2  - Climate affects both the distribution and abundance of isopods. Humidity and moisture affect their activity and distribution. Survival of juveniles is largely dependent on moisture. The reproductive pattern is affected by temperature and light. Food affects growth and thus, indirectly, also reproduction, as larger females tend to produce larger broods and more frequent broods than smaller ones. Generally in isopods there is little evidence to suggest that food is a very important factor affecting their abundance. Both semelparity and iteroparity are found in isopods and both reproductive strategies are apparently successful. Mortality factors affect the oocytes, the marsupial stages, and most of all the newly released individuals . Apart from climatic factors, predation and, to a lesser extent, parasitism are the main causes of mortality. Longevity of isopods ranges from one to five years. Occasional population explosions ofisopods are known to take place, their cause being unknown.
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44473
ER  - 
TY  - CHAP
A1  - Ellgring, Heiner
T1  - Nonverbale Indikatoren des psychischen Befindens
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42082
ER  - 
TY  - JOUR
A1  - Heinsen, Helmut
A1  - Heinsen, YL
T1  - Strain-specific differences in the vermian granular layer of albino rats
N2  - Foliation of the cerebella of Sprague-Dawley rats (strain Han:SPRD) is more advanced than in Wistar rats (strain Chbb:THOM). The differences expressed as length of the granular layer in median sections were significant in lobules VIa, VIII, IX and X. The length of the other vermian lobules is generally higher in the former strain. With regard to the volume of the granular layer, the situation is reversed, indicating that the lateral extent and thickness of vermian lobules in Wistar rats (strain Chbb:THOM) is generally larger. These quantitative differences may express differences in cerebellar microcircuitry and fibre connections in the cortex of Wistar and Sprague-Dawley rats.
KW  - Albino rats
KW  - Cerebellum
KW  - Granular layer
KW  - Quantitative anatomy
KW  - Strain differences
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-45735
ER  - 
TY  - BOOK
A1  - Klawitter, Jörg
T1  - Charles Sanders Peirce: Realität, Wahrheit, Gott: Einblicke in Leben und Werk des Begründers des Pragmatismus
N2  - No abstract available.
KW  - Charles S. Peirce
KW  - Philosophie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-44271
SN  - 3-88479-194-X
N1  - Zugl. Dissertation, Würzburg, 1984, u. d. T. Untersuchung zu den Begriffen Realität, Wahrheit, Gott bei Charles Sanders Peirce
ER  - 
TY  - JOUR
A1  - Franke, Werner W.
A1  - Scheer, Ulrich
A1  - Zentgraf, Hanswalter
T1  - Organization of transcriptionally active and inactive chromatin
N2  - No abstract available
KW  - Deutschland
KW  - Gefäßpflanzen
KW  - Verzeichnis
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40588
ER  - 
TY  - BOOK
A1  - Wolf, Norbert Richard
A1  - Domröse, Gerd
A1  - Sprothen, Otmar
A1  - Wallraff, Dieter
A1  - Danner, Klaus
T1  - List Sprachbuch 8
N2  - No abstract available
KW  - Deutschunterricht
KW  - Lehrmittel
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41726
ER  - 
TY  - GEN
T1  - Jahresbericht 1983
T1  - Annual Report 1983
N2  - Die Entwicklung der Universitätsbibliothek Würzburg im Jahr 1983.
N2  - Annual Report of the University Library of Würzburg, 1983.
T3  - Jahresbericht der Universitätsbibliothek Würzburg - 1983 
KW  - Würzburg
KW  - Universitätsbibliothek
KW  - Bericht
KW  - Jahresbericht
KW  - Würzburg
KW  - University Library
KW  - Report
KW  - Annual Report
KW  - Wuerzburg
KW  - Wurzburg
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-42263
ER  - 
TY  - JOUR
A1  - Knapp, Stefan
A1  - Hacker, Jörg
A1  - Then, Irene
A1  - Müller, Dorothee
A1  - Goebel, Werner
T1  - Multiple copies of hemolysin genes and associated sequences in the chromosome of uropathogenic Escherichia coli strains
N2  - The 06 serogroup Escherichia coli strain 536 carries two hemolysin (hly) determinants integrated into the chromosome. The two hly determinants are not completely identical, either functionally or structurally, as demonstrated by spontaneous deletion mutants carrying only one of them and by cloning each of the two determinants separately into cosmid vectors. Each hly determinant is independently deleted at a frequency of 10-4 , leading to variants which exhibit similar levels of internal hemolysin but different amounts of secreted hemolysin. The two hly determinants were also identified in the 04 E. coli strain 519. The three E. coli strains 251, 764, and 768, which belong to the serogroup 018, and the 04 strain 367 harbor a single chromosomal hly determinant, as demonstrated by hybridization with hly-gene-specific probes. However, a hybridization probe derived from a sequence adjacent to the hlyC-proximal end of the plasmid pHlyl52-encoded hly determinant hybridizes with several additional chromosomal bands in hemolytic 018 and 06 E. coli strains and even in E. coli K-12. The size ofthe probe causing the multiple hybridization suggests a 1,500- to 1,800-base pair sequence directly flanking hlyC. Spontaneous hemolysin-negative mutants were isolated from strains 764 and 768, which had lost the entire hly determinant but retained all copies of the hlyC-associated sequence. This sequence is not identical to a previously identified (J. Hacker, S. Knapp, and W. Goebel, J. Bacteriol. 154:1145-1154, 1983) somewhat smaller (about 850 base pairs) sequence flanking the other (hlyBb-proximal) end of the plasmid pHlyl52-encoded hly determinant which, as shown here, exists also in multiple copies in these hemolytic E. coli strains and in at least two copies in E. coli K-12. In contrast to the plasmid-encoded hly determinant which is directly flanked at both ends by these two diJJerent sequences, the chromosomal hly determinants are not immediately flanked by such sequences.
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40278
ER  - 
TY  - JOUR
A1  - Albert, Bernhard
A1  - Berning, Wilfried
A1  - Burschka, Christian
A1  - Hünig, Siegfried
A1  - Prokschy, Frank
T1  - Azobrücken aus Azinen, IV. Intramolekulare [2 + 2]-Photocycloaddition zwischen parallelen C = C- und N = N-Bindungen
T1  - Azo Bridges from Azines, IV.Intramolecular [2 + 2]-Photocycloaddition of Parallel C = C and N = N Bonds
N2  - In den starren Molekülen 1- 10 reagieren die benachbarten parallelen C = C- und N = N-Bindungen nahezu quantitativ unter Photocyclisierung lU den l,2-Diazetidinen 11-10, deren Struktur spektroskopisch und für 13 durch Kristallstrukturanalyse bewiesen wird. Die in Abwesenheit der C = C-Bindung beobachtete Photo-Denitrogenierung unterbleibt selbst bei den empfindlichen Derivaten des 2,3-Diazabicyclo[2.2.11heptens. Photocyclisierung von 6 mit lwei zur N=N· Bindung benachbarten C=C-Bindungen tritt nur mit der Norbornendoppelbindung ein.
N2  - The parallel C = C and N = N bonds in the rigid molecules 1- 10 photocyclile nearly quantitatively, forming l,2-diautidines 11-10. Their structure is confirmed by spectroscopic methods and for 13 by X-ray analysis. Radiation induced denitrogenation, the normal reaction for similar compounds without neighbouring C = C bonds, is suppressed even with the sensitive derivatives of 2,3-diazabicyclo[1.2.1)heptene. Photocyc1ization of 6, carrying two neighbouring C=C bonds, inc1udes only the norbornene bond.
KW  - Chemie
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-31314
ER  - 
TY  - JOUR
A1  - Scheer, Ulrich
A1  - Hinssen, Horst
A1  - Franke, Werner W.
A1  - Jockusch, Brigitte M.
T1  - Microinjection of actin-binding proteins and actin antibodies demonstrates involvement of nuclear actin in transcription of lampbrush chromosomes
N2  - Nuclei of amphibian oocytes contain large amounts of actin, mostly in unpolymerized or short-polymer form. When antibodies to actin or actin-binding proteins (fragmin and the actin modulator from mammalian smooth muscle) are injected into nuclei of living oocytes of Pleurodeles waltlii, transcription of the lampbrush chromosomes, but not of the rRNA genes, is inhibited. When transcription is repressed by drugs or RNA is digested by microinjection of RNAase into oocyte nuclei, an extensive meshwork of actin filament bundles is seen in association with the isolated lampbrush chromosomes. These observations indicate a close relationship between the state of nuclear actin and transcriptional activity and suggest that nuclear actin may be involved in transcriptional events concerning protein-coding genes.
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39706
ER  - 
TY  - JOUR
A1  - Scheer, Ulrich
A1  - Schmidt-Zachmann, Marion S.
A1  - Hügle, Barbara
A1  - Franke, Werner W.
T1  - Identification and localization of a novel nucleolar protein of a high molecular weight by a monoclonal antibody
N2  - A monoclonal murine antibody (No-I 14) is described which reacts specifically with a polypeptide of molecular weight (M,) 180000 present in low-speed nuclear pellets from oocytes and somatic cells of Xenopus laevis and X. borealis and in isolated amplified nucleoli. Two-dimensional gel electrophoresis has revealed the acidic nature of this polypeptide (isoelectric at pH of ca 4.2 in the presence of 9.5 M urea). A relatively large proportion of the protein is extracted at elevated ionic strength( i.e., at 0.4-0.5 M alkali salt) in a form sedimenting at approx. 7-8S , compatible with a monomeric state. It is also extracted by digestion with RNase but not with DNase. In immunofluorescence microscopy, antibody No-114 stains intensely nucleoli of oocytes and all somatic cells examined , including the residual nucleolar structure of Xenopus erythrocytes which are transcriptionally inactive. During mitosis the antigen does not remain associated with the nucleolar organizer regions (NOR) of chromosomes but is released and dispersed over the cytoplasm until telophase when it re-associates with the reforming interphase nucleoli. At higher resolution the immunofluorescent region is often resolved into a number of distinct subnucleolar components of varied size and shape. Immunoelectron microscopy using colloidal gold-coupled secondary antibodies reveals that the M, 180000 protein is confined to the dense fibrillar component of the nucleolus. This conclusion is also supported by its localization in the fibrillar part of segregated nucleoli of cells treated with actinomycin D. We conclude that nucleoli contain a prominent protein of M, 180000 which contributes to the general structure of the dense fibrillar component of the interphase nucleolus , independent of its specific transcriptional activity.
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-39786
ER  - 
TY  - CHAP
A1  - Ellgring, Johann Heinrich
T1  - Ethologie
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-34170
ER  - 
TY  - JOUR
A1  - König, Dorothea
T1  - Materialien zu den Fragmenten des Mihanovic-Homiliars
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38566
ER  - 
TY  - JOUR
A1  - König, Dorothea
T1  - Die "Davidias" des Marko Marulic / Winfried Baumann
N2  - Winfried Baumann, Die "Davidias" des Marko Marulic, Frankfurt, 1984
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38576
ER  - 
TY  - JOUR
A1  - König, Dorothea
T1  - Die glagolitische Druckerei von Rijeka und ihr historisches Knižice od žitije rimskih arhierov i cesarov / Günther Tutschke
N2  - Günther Tutschke, Die glagolitische Druckerei von Rijeka und ihr historisches Knižice od žitije rimskih arhierov i cesarov, München, 1983
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-38584
ER  - 
TY  - JOUR
A1  - Linsenmair, Karl Eduard
T1  - Comparative studies on the social behaviour of the desert isopod Hemilepistus reaumuri and of a Porcellio species
N2  - Behavioural adaptations have made the desert isopod Hemilepistus reaumuri the most successful herbivore and detritivore of the macrofauna of many arid areas in North Africa and Asia Minor. For survival and reproduction Hemilepistus is dependent on burrows. New burrows can only be dug during spring. With the time-consuming digging of a burrow, Hemilepistus has only made the first step towards solving its ecological problems. The burrows are vital and have to be continuously defended against competitors. This requirement is met by co-operation of individuals within the framework of a highly developed social behaviour. In spring adults form monogamous pairs in which partners recognize each other individually and later form, with their progeny, strictly closed family communities. Hemilepistus is compared with a Porcellio' sp. which has developed, convergently, a social behaviour which resembles that of Hemilepistus in many respects, but differs essentially in some aspects, partly reflecting differences in ecological requirements. This and a few other Porcellio species demonstrate some possible steps in the evolution of the social behaviour of Hemilepistus. The female Hemilepistus is-in contrast to Porcellio sp. - semelparous and the selective advantages of monogamy in its environment are not difficult to recognize. This chapter discusses how this mating system could have evolved and especially why monogamous behaviour is also the best method for the Hemilepistus male to maximize its reproductive success. The cohesion of pairs and of family communities in Hemilepistus is based on a highly developed chemical communication system. Individual- and family-specific badges owe their specificity to genetically determined discriminating substances. The nature of the badges raises a series of questions: e.g. since alien badges release aggression, how do parents avoid cannibalizing their young? Similar problems arise from the fact that family badges are mixtures of chemical compounds of very low volatility with the consequence that they can only be transferred by direct contact and that during moulting all substances are lost which an individual does not produce itself. It is shown that in solving these problems inhibiting properties (presumably substances) and learning play a dominant role.
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30846
ER  - 
TY  - JOUR
A1  - Simon, Markus M.
A1  - Moll, Heidrun
A1  - Prester, Marlot
A1  - Nerz, Gaby
A1  - Eichmann, Klaus
T1  - Immunoregulation by mouse T-cell clones. I. Suppression and amplification of cytotoxic responses by cloned H-Y-specific cytolytic T lymphocytes.
N2  - H-Y-specific and H-2Db-restricted, Lyt-1 "2+ T-cell clones (CTLL) with graded specific cytotoxic activities on male C57BL/6 (B6) target cells (1E3, +++; 2C5, ++; 2A5, +, 3E6, ±) were tested for their capacity to inhibit the generation of H-Y-specific cytotoxic T lymphocytes (CTL) in vitro. Addition of irradiated lymphocytes of CTLL 1E3 and CTLL 3E6 but not those of CTLL 2A5 or CTLL 2C5 abolished the generation of CTL from in vivo primed H-Y-specific precursor cells (CTLP) when added to fresh mixed-lymphocyte cultures (MLC). Exogenous sources of T-cell growth factors (TCGF) did not overcome suppression. Rather the presence of TCGF resulted in a further enhancement of suppressive activities in CTLL 1E3 and 3E6 and the induction of similar activities in cells from CTLL 2A5 and 2C5, which by themselves were not inhibitory. Moreover when added to similar MLC on Day 1 instead of Day 0, only irradiated cells of CTLL 3E6 but not those of the other three CTLL were suppressive. Induction of suppressive activities in H-Y-specific CTLL was independent of the appropriate male stimulator cells since it was also observed in MLC induced by irrelevant antigens (H-2, trinitrophenol). Furthermore at low cell numbers, irradiated lymphocytes from any of the CTLL consistently enhanced CTL activities generated from H-Y-specific CTLP. This augmenting activity, which was not TCGF, could be transferred by soluble mediators present in antigen-sensitized CTLL cultures. Thus, these data indicate (i) that cytotoxic effector cells can function as suppressor cells in the generation of CTL, (ii) that the cytotoxic activity of cloned CTL does not correlate with their capacity to suppress CTL responses, (iii) that the inhibition of CTL responses by CTLL is not due to simple consumption of T-cell growth factors produced in MLC, and (iv) that different CTL clones may interfere with the generation of CTL at different stages of their maturation. Moreover, the experiments suggest an antigen-independent enhancement of suppression by the interaction of CTL with lymphokines. Together with the augmenting activity evoked by cloned CTL the data provide strong evidence for the expression of multiple immunological functions by one particular subset of T cells and suggest that cytotoxic effector cells can differentially regulate the maturation and/or clonal expression of their precursor cells.
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30892
ER  - 
TY  - JOUR
A1  - Scheer, Ulrich
A1  - Hügle, Barbara
A1  - Hazan, Rachel
A1  - Rose, Kathleen M.
T1  - Drug-induced dispersal of transcribed rRNA genes and transcriptional products: Immunolocalization and silver staining of different nucleolar components in rat cells treated with 5,6-dichloro-1-Beta-D-ribofuranosylbenzimidazole
N2  - Upon incubation of cultured rat cells with the adenosine analogue 5,6-dichloro-l-&#946;- D-ribofuranosylbenzimidazole (DRB), nucleoli reversibly dissociate into their substructures, disperse throughout the nuclear interior, and form nucleolar "necklaces". We have used this experimental system, which does not inhibit transcription of the rRNA genes, to study by immunocytochemistry the distribution of active rRNA genes and their transcriptional products during nucleolar dispersal and recovery to normal morphology. Antibodies to RNA polymerase I allow detection of template-engaged polymerase, and monoclonal antibodies to a ribosomal protein (S 1) of the small ribosomal subunit permit localization of nucleolar preribosomal particles. The results show that, under the action of DRB transcribed rRNA, genes spread throughout the nucleoplasm and finally appear in the form of several rows, each containing several (up to 30) granules positive for RNA polymerase land argyrophilic proteins. Nucleolar material containing preribosomal particles also appears in granular structures spread over the nucleoplasm but its distribution is distinct from that of rRNA gene-containing granules. We conclude that, although transcriptional units and preribosomal particles are both redistributed in response to DRB, these entities retain their individuality as functionally defined subunits. We further propose that each RNA polymerase-positive granular unit represents a single transcription unit and that each continuous array of granules ("string of nucleolar beads") reflects the linear distribution of rRNA genes along a nucleolar organizer region. Based on the total number of polymerase I-positive granules we estimate that a minimum of 60 rRNA genes are active during interphase of DRB-treated rat cells.
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33216
ER  - 
TY  - CHAP
A1  - Scheer, Ulrich
A1  - Rose, Kathleen M.
T1  - Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry
N2  - Rabbit antibodies to RNA polymerase I from a rat hepatoma have been used to localize the enzyme in a variety of cells at the light and electron microscopic level. In interphase cells the immunofluorescence pattern indicated that polymerase I is contained exclusively within the nucleolus. That this fluorescence, which appeared punctated rather than uniform, represented transcriptional complexes of RNA polymerase I and rRNA genes was suggested by the observation that it was enhanced in regenerating liver and in a hepatoma and was markedly diminished in cells treated with actinomycin D. Electron microscopic immunolocalization using gold-coupled second antibodies showed that transcribed rRNA genes are located in, and probably confined to, the fibrillar centers of the nucleolus. In contrast, the surrounding dense fibrillar component, previously thought to be the site of nascent prerRNA, did not contain detectable amounts of polymerase I. During mitosis, polymerase I molecules were detected by immunofluorescence microscopy at the chromosomal nucleolus organizer region, indicating that a considerable quantity of the enzyme remains bound to the rRNA genes. From this we conclude that rRNA genes loaded with polymerase I molecules are transmitted from one cell generation to the next one and that factors other than the polymerase itself are involved in the modulation of transcription of DNA containing rRNA genes during the cell cycle.
KW  - nucleolus
KW  - nucleolus organizer
KW  - fibrillar centers
KW  - rRNA genes
KW  - anti-RNA polymerase I antibodies
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33223
ER  - 
TY  - CHAP
A1  - Ruhe, Ernstpeter
T1  - La peur de la transgression: A propos du Livre d'Enanchet et du Bestiaire d'amours.
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-36841
ER  - 
TY  - CHAP
A1  - Ruhe, Ernstpeter
T1  - Inventio devenue troevemens: La recherche de la matière au moyen âge.
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-36816
ER  - 
TY  - JOUR
A1  - Ruhe, Ernstpeter
T1  - Der Roman als totales Spiel: Alain Robbe-Grillet, Topologie d'une cité fantôme.
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-36889
ER  - 
TY  - CHAP
A1  - Ruhe, Ernstpeter
T1  - Der chevalier errant auf enzyklopädischer Fahrt
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33722
ER  - 
TY  - CHAP
A1  - Ruhe, Ernstpeter
T1  - Mokutu et le coq divinatoire
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33639
ER  - 
TY  - JOUR
A1  - Christl, Manfred
A1  - Brunn, Erich
A1  - Lanzendorfer, Franz
T1  - Reactions of Benzvalene with Tetracyanoethylene, 2,3-Dichloro-5,6-dicyano-rho-benzoquinone, Chlorosulfonyl Isocyanate, and Sulfur Dioxide. Evidence for Concerted 1,4-Cycloadditions to a Vinylcyclopropane System
N2  - No abstract available
Y1  - 1984
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30052
ER  -