TY  - JOUR
A1  - Zhou, Xiang
A1  - Wuchter, Patrick
A1  - Egerer, Gerlinde
A1  - Kriegsmann, Mark
A1  - Mataityte, Aiste
A1  - Koelsche, Christian
A1  - Witzens-Harig, Mathias
A1  - Kriegsmann, Katharina
T1  - Role of virological serum markers in patients with both hepatitis B virus infection and diffuse large B-cell lymphoma
JF  - European Journal of Haematology
N2  - Background
Causality between hepatitis B virus (HBV) infection and diffuse large B-cell lymphoma (DLBCL) was reported in various studies. However, the implication of different virological serum markers of HBV infection in patients with both HBV infection and DLBCL is not fully understood. The aim of this study was to investigate the impact of HBV markers on overall survival (OS) and progression-free survival (PFS) in patients with both HBV infection and DLBCL.

Methods
In this study, patients (n = 40) diagnosed with both HBV infection and DLBCL were identified between 2000 and 2017. Six patients with hepatitis C virus (HCV) and/or human immunodeficiency virus (HIV) co-infection were excluded from this study. We retrospectively analyzed patients’ demographic characteristics, treatment, and the prognostic impact of different HBV markers at first diagnosis of DLBCL (HBsAg, anti-HBs, HBeAg, anti-HBe, and HBV-DNA) on OS and PFS.

Results
The majority of patients (n = 21, 62%) had advanced disease stage (III/IV) at diagnosis. In the first-line therapy, 24 patients (70%) were treated with R-CHOP regimen (rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisolone). HBeAg positive patients had a trend toward inferior OS and PFS compared with HBeAg negative patients. Anti-HBe positive patients had a statistically significant better OS and PFS compared with anti-HBe negative group (both P < .0001). Viremia with HBV-DNA ≥ 2 × 107 IU/L had a significant negative impact on OS and PFS (both P < .0001).

Conclusion
High activity of viral replication is associated with a poor survival outcome of patients with both HBV infection and DLBCL.
KW  - hepatitis B virus
KW  - diffuse large B-cell lymphoma
KW  - prognosis
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-258442
VL  - 103
IS  - 4
ER  -