TY  - JOUR
A1  - Lombardi, Jolina
A1  - Mayer, Benjamin
A1  - Semler, Elisa
A1  - Anderl‐Straub, Sarah
A1  - Uttner, Ingo
A1  - Kassubek, Jan
A1  - Diehl‐Schmid, Janine
A1  - Danek, Adrian
A1  - Levin, Johannes
A1  - Fassbender, Klaus
A1  - Fliessbach, Klaus
A1  - Schneider, Anja
A1  - Huppertz, Hans‐Jürgen
A1  - Jahn, Holger
A1  - Volk, Alexander
A1  - Kornhuber, Johannes
A1  - Landwehrmeyer, Bernhard
A1  - Lauer, Martin
A1  - Prudlo, Johannes
A1  - Wiltfang, Jens
A1  - Schroeter, Matthias L.
A1  - Ludolph, Albert
A1  - Otto, Markus
T1  - Quantifying progression in primary progressive aphasia with structural neuroimaging
JF  - Alzheimer's & Dementia
N2  - Introduction
The term primary progressive aphasia (PPA) sums up the non‐fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression.
Methods
Structural brain imaging and an extensive assessment were applied at baseline and up to 4‐year(s) follow‐up in 269 participants. With automated atlas‐based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials.
Results
At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (–17%) and of the left temporal lobe for svPPA (–34%) and lvPPA (–24%). Severest progression within 1‐year follow‐up occurred in the basal ganglia in nfvPPA (–7%), in the hippocampus/amygdala in svPPA (–9%), and in (medial) temporal regions in lvPPA (–6%).
Conclusion
PPA presents as a left‐dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant‐specific.
KW  - atlas‐based volumetry
KW  - disease progression
KW  - frontotemporal dementia
KW  - longitudinal magnetic resonance imaging
KW  - primary progressive aphasia
KW  - sample size calculation
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-262605
VL  - 17
IS  - 10
SP  - 1595
EP  - 1609
ER  - 
TY  - JOUR
A1  - Kübler, Andrea
A1  - Hautzinger, Martin
A1  - Ludolph, Albert
A1  - Dickhaus, Thorsten
A1  - Real, Ruben G. L.
T1  - Well-being in amyotrophic lateral sclerosis: a pilot experience sampling study
N2  - Objective: The aim of this longitudinal study was to identify predictors of instantaneous well-being in patients with amyotrophic lateral sclerosis (ALS). Based on flow theory well-being was expected to be highest when perceived demands and perceived control were in balance, and that thinking about the past would be a risk factor for rumination which would in turn reduce well-being.

Methods: Using the experience sampling method, data on current activities, associated aspects of perceived demands, control, and well-being were collected from 10 patients with ALS three times a day for two weeks.

Results: Results show that perceived control was uniformly and positively associated with well-being, but that demands were only positively associated with well-being when they were perceived as controllable. Mediation analysis confirmed thinking about the past, but not thinking about the future, to be a risk factor for rumination and reduced well-being.

Discussion: Findings extend our knowledge of factors contributing to well-being in ALS as not only perceived control but also perceived demands can contribute to well-being. They further show that a focus on present experiences might contribute to increased well-being.
KW  - amyotrophic lateral sclerosis
KW  - ALS
KW  - coping
KW  - well-being
KW  - experience sampling
KW  - ESM
KW  - reminiscence
KW  - rumination
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-113057
ER  -