TY  - JOUR
A1  - Sirén, Anna-Leena
A1  - Letts, G.
A1  - Feuerstein, G.
T1  - N-Acetyl-leukotriene E\(_4\) is a potent constrictor of rat mesenteric vessels
N2  - N-Acetyl-leukotriene E\(_4\) administered to conscious freely moving rats produced a dose-dependent vasoconstriction in the mesenteric vessels which led to profound reduction of blood flow to the gut. Renal and hindquarter blood flow and vascular resistance were not affected even by high doses of N-acetyl-leukotriene E\(_4\) . N-Acetyl-leukotriene E\(_4\) was 10-fold more potent than the thromboxane analog U-46619 and 1000-fold more potent than prostaglandin F\(_{2a}\) but 2-5-fold less potent than leukotriene D\(_4\)/E\(_4\) to induce mesenteric vasoconstriction. These data indicatc that N-acetylleukotriene E\(_4\) is a biologically active metabolite of peptide leukotrienes, and might play a role in cardiovascular derangements mediated by leukotrienes.
KW  - Neurobiologie
KW  - Peptide-leukotrienes
KW  - N-Acetyl-leukotriene E4
KW  - Prostaglandins
KW  - Mesenteric circulation
KW  - Anaphylactic shock
Y1  - 1988
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63196
ER  -