TY  - JOUR
A1  - Graser, Stephanie
A1  - Liedtke, Daniel
A1  - Jakob, Franz
T1  - TNAP as a new player in chronic inflammatory conditions and metabolism
JF  - International Journal of Molecular Sciences
N2  - This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here.
KW  - TNAP
KW  - Hypophosphatasia
KW  - HPP
KW  - mineralization
KW  - nervous system
KW  - inflammation
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-258888
SN  - 1422-0067
VL  - 22
IS  - 2
ER  - 
TY  - JOUR
A1  - Höhn, Stefan
A1  - Frimmel, Hartwig E.
A1  - Debaille, Vinciane
A1  - Price, Westley
T1  - Pre‐Klondikean oxidation prepared the ground for Broken Hill‐type mineralization in South Africa
JF  - Terra Nova
N2  - New Cu isotope data obtained on chalcopyrite from the Black Mountain and the Broken Hill deposits in the medium‐ to high‐grade metamorphic Aggeneys‐Gamsberg ore district (South Africa) require a revision of our understanding of the genesis of metamorphic Broken Hill‐type massive sulphide deposits. Chalcopyrite from both deposits revealed unusually wide ranges in δ\(^{65}\)Cu (−2.41 to 2.84‰ NIST 976 standard) in combination with distinctly positive mean values (0.27 and 0.94‰, respectively). This is interpreted to reflect derivation from various silicate and oxide precursor minerals in which Cu occurred in higher oxidation states. Together with the observation of a typical supergene base metal distribution within the deposits and their spatial association with an unconformity only meters above the ore horizon, our new data are best explained by supergene oxidation of originally possibly SEDEX deposits prior to metamorphic sulphide formation, between the Okiepian (1,210–1,180 Ma) and Klondikean (1,040–1,020 Ma) orogenic events.
KW  - South Africa
KW  - mineralization
KW  - Broken Hill
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-218545
VL  - 33
IS  - 2
SP  - 168
EP  - 173
ER  -