TY  - JOUR
A1  - Salvador, Ellaine
A1  - Burek, Malgorzata
A1  - Löhr, Mario
A1  - Nagai, Michiaki
A1  - Hagemann, Carsten
A1  - Förster, Carola Y.
T1  - Senescence and associated blood-brain barrier alterations in vitro
JF  - Histochemistry and Cell Biology
N2  - Progressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood-brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and changes in the BBB has not yet been thoroughly explored. Moreover, the lack of in vitro models for the study of the mechanisms involved in those changes impede further and more in-depth investigations in the field. For this reason, we herein present an in vitro model of the senescent BBB and an initial attempt to identify senescence-associated alterations within.
KW  - senescence
KW  - in vitro model
KW  - aging
KW  - CNS diseases
KW  - blood–brain barrier
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-267435
SN  - 1432-119X
VL  - 156
IS  - 3
ER  -