TY  - JOUR
A1  - Rommel, Marcel G. E.
A1  - Milde, Christian
A1  - Eberle, Regina
A1  - Schulze, Harald
A1  - Modlich, Ute
T1  - Endothelial–platelet interactions in influenza‐induced pneumonia: A potential therapeutic target
JF  - Anatomia, Histologia, Embryologia
N2  - Every year, influenza viruses spread around the world, infecting the respiratory systems of countless humans and animals, causing illness and even death. Severe influenza infection is associated with pulmonary epithelial damage and endothelial dysfunction leading to acute lung injury (ALI). There is evidence that an aggressive cytokine storm and cell damage in lung capillaries as well as endothelial/platelet interactions contribute to vascular leakage, pro‐thrombotic milieu and infiltration of immune effector cells. To date, treatments for ALI caused by influenza are limited to antiviral drugs, active ventilation or further symptomatic treatments. In this review, we summarize the mechanisms of influenza‐mediated pathogenesis, permissive animal models and histopathological changes of lung tissue in both mice and men and compare it with histological and electron microscopic data from our own group. We highlight the molecular and cellular interactions between pulmonary endothelium and platelets in homeostasis and influenza‐induced pathogenesis. Finally, we discuss novel therapeutic targets on platelets/endothelial interaction to reduce or resolve ALI.
KW  - endothelial cell
KW  - influenza
KW  - interaction
KW  - laboratory animals
KW  - lung injury
KW  - platelet
KW  - pneumonia
KW  - therapy
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-213610
VL  - 49
IS  - 5
SP  - 606
EP  - 619
ER  -