TY  - JOUR
A1  - Sinn, Stefan
A1  - Eichler, Mirjam
A1  - Müller, Lothar
A1  - Bünger, Daniel
A1  - Groll, Jüergen
A1  - Ziemer, Gerhard
A1  - Rupp, Frank
A1  - Northoff, Hinnak
A1  - Geis-Gerstorfer, Jürgen
A1  - Gehring, Frank K.
A1  - Wendel, Hans P.
T1  - NCO-sP(EO-stat-PO) Coatings on Gold Sensors-a QCM Study of Hemocompatibility
JF  - Sensors
N2  - The reliability of implantable blood sensors is often hampered by unspecific adsorption of plasma proteins and blood cells. This not only leads to a loss of sensor signal over time, but can also result in undesired host vs. graft reactions. Within this study we evaluated the hemocompatibility of isocyanate conjugated star shaped polytheylene oxide-polypropylene oxide co-polymers NCO-sP(EO-stat-PO) when applied to gold surfaces as an auspicious coating material for gold sputtered blood contacting sensors. Quartz crystal microbalance (QCM) sensors were coated with ultrathin NCO-sP(EO-stat-PO) films and compared with uncoated gold sensors. Protein resistance was assessed by QCM measurements with fibrinogen solution and platelet poor plasma (PPP), followed by quantification of fibrinogen adsorption. Hemocompatibility was tested by incubation with human platelet rich plasma (PRP). Thrombin antithrombin-III complex (TAT), beta-thromboglobulin (beta-TG) and platelet factor 4 (PF4) were used as coagulation activation markers. Furthermore, scanning electron microscopy (SEM) was used to visualize platelet adhesion to the sensor surfaces. Compared to uncoated gold sensors, NCO-sP(EO-stat-PO) coated sensors revealed significant better resistance against protein adsorption, lower TAT generation and a lower amount of adherent platelets. Moreover, coating with ultrathin NCO-sP(EO-stat-PO) films creates a cell resistant hemocompatible surface on gold that increases the chance of prolonged sensor functionality and can easily be modified with specific receptor molecules.
KW  - self-assembled monolayers
KW  - 316L stainless-steel
KW  - protein adsorption
KW  - poly(ethylene glycol)
KW  - platelet-adhesion
KW  - blood-plasma
KW  - surfaces
KW  - biosensor
KW  - cell self-assembled monolayers
KW  - cell coagulation
KW  - surface coating
KW  - biosensors
KW  - hemocompatibility
KW  - QCM
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-141110
VL  - 11
IS  - 5
ER  - 
TY  - THES
A1  - Hipp, Matthias
T1  - Modifikation elektrochemisch auf Titan aufgebrachter Calciumhydroxidbeschichtungen durch Fremdmetallionendotierung
T1  - Modification of electrochemically deposited calcium hydroxide surface coatings on titanium by different metal ions
N2  - Die Verwendung von im Knochen befestigten Implantaten und Endoprothesen aus Titan, sowie Osteosyntheseverfahren mittels Plattenapplikation stellen häufige Routineeingriffe in der Medizin dar. Die Infektion einer Endoprothese oder Osteosyntheseplatte mit Biofilmbildung bedeutet dabei eine schwerwiegende postoperative Komplikation. Ein Schwerpunkt medizinischer Forschung beschäftigt sich aus diesem Grunde mit der Entwicklung antiseptischer Oberflächen. Die vorliegende Arbeit beschreibt die Weiterentwicklung einer in der Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde der Universitätsklinik Würzburg entwickelten elektrochemischen Calciumhydroxidbeschichtung auf Titan. Durch die gezielte Dotierung der Ausgangsschicht mit Silberionen konnte die starke kurzfristige Antisepsis des Calciumhydroxides mit einer wirksamen und langfristigen bakteriziden Wirkung des Silbers kombiniert werden.
N2  - The use of bone-fixed implants, endoprosthesis and osteosythesis plates made of titanium are common treatements in medicine. Post-operative infections associated with biofilm-formation are a serious complication in surgery. Therefore, a focus in medical research deals with the developement of antiseptic surface coatings. This study describes the advancement of an electrochemical deposited surface coating made of calcium hydroxide on titanium, developed at “Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde” at University Hospital Würzburg. It was possible to combine the strong short-term antisepsis of calcium hydroxide with an effective long-term bactericide action by silber ions.
KW  - Calciumhydroxid
KW  - Hydroxylapatit
KW  - Beschichtungsanlage
KW  - Antisepsis
KW  - Silber
KW  - Osteosynthese
KW  - calciumhydroxide
KW  - surface coating
KW  - antisepis
KW  - silver
KW  - osteosynthesis
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-55114
ER  -