TY  - JOUR
A1  - Ferianec, Vladimír
A1  - Fülöp, Matej
A1  - Ježovičová, Miriam
A1  - Radošinská, Jana
A1  - Husseinová, Marta
A1  - Feriancová, Michaela
A1  - Radošinská, Dominika
A1  - Barančík, Miroslav
A1  - Muchová, Jana
A1  - Hȍgger, Petra
A1  - Ďuračková, Zdeňka
T1  - The oak−wood extract Robuvit\(^®\) improves recovery and oxidative stress after hysterectomy: a randomized, double-blind, placebo-controlled pilot study
JF  - Nutrients
N2  - Hysterectomy has a variety of medical indications and improves pre-operative symptoms but might compromise the quality of life during recovery due to symptoms such as fatigue, headache, nausea, depression, or pain. The aim of the present study was to determine the effect of a standardized extract from French oak wood (Quercus robur) containing at least 40% polyphenols of the ellagitannins class, Robuvit\(^®\), on convalescence and oxidative stress of women after hysterectomy. Recovery status was monitored with the SF-36 questionnaire. The supplementation with Robuvit\(^®\) (300 mg/day) during 4 weeks significantly improved general and mental health, while under placebo some items significantly deteriorated. Oxidative stress and enhancement of MMP–9 activity was significantly reduced by Robuvit\(^®\) versus placebo. After 8 weeks of intervention, the patients’ condition improved independently of the intervention. Our results suggest that the use of Robuvit\(^®\) as a natural supplement relieves post-operative symptoms of patients after hysterectomy and reduces oxidative stress. The study was registered with ID ISRCTN 11457040 (13/09/2019).
KW  - hysterectomy
KW  - Robuvit\(^®\)
KW  - oak wood extract
KW  - post-operative recovery
KW  - oxidative stress
KW  - matrix metalloproteinases
KW  - complementary medicine
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-203265
SN  - 2072-6643
VL  - 12
IS  - 4
ER  - 
TY  - JOUR
A1  - Volpp, Linda
A1  - Ferianec, Vladimír
A1  - Ježovičová, Miriam
A1  - Ďuračková, Zdeňka
A1  - Scherf-Clavel, Oliver
A1  - Högger, Petra
T1  - Constituents and Metabolites of a French Oak Wood Extract (Robuvit®) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy
JF  - Frontiers in Pharmacology
N2  - Ellagitannins are signature constituents of oak wood and their consumption has been associated with various health benefits. In vivo, they undergo metabolic degradation including gut microbial metabolism yielding urolithins. Only limited data is available about compounds being present in blood after intake of an extract from French oak wood, Robuvit®. In the course of a randomized, double-blind, controlled clinical investigation, 66 patients undergoing hysterectomy received placebo or 300 mg Robuvit® per day before and over 8 weeks after surgery. Serum and blood cell samples were analyzed by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The number of urolithin producers and the urolithin levels increased after intake of Robuvit®. In serum samples, the median concentration of urolithin A was 14.0 ng/ml [interquartile range (IQR) 57.4] after 8 weeks. Urolithin B was determined at 22.3 ng/ml (IQR 12.6), urolithin C at 2.66 ng/ml (IQR 2.08). In blood cells, lower concentrations and only urolithins A and B were detected. A statistically significant association of lower post-surgical pain scores with metabotype A was detected (p < 0.05). To conclude, supplementation with French oak wood extract raised urolithin generation in patients and suggested health advantages for urolithin-producers.
KW  - polyphenols
KW  - urolithins
KW  - oak wood
KW  - post-surgery recovery
KW  - human
KW  - liquid chromatography electrospray ionization tandem mass spectrometry
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-200105
SN  - 1663-9812
VL  - 11
IS  - 74
ER  -