TY  - JOUR
A1  - Leininger, H.
A1  - Lanzendörfer, F.
A1  - Christl, Manfred
T1  - Über die Reduktion des Benzvalenozonids zum cis-1,3-Cyclobutandimethanol mit LiAlH\(_4\)
N2  - No abstract available
KW  - Organische Chemie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-58130
ER  - 
TY  - CHAP
A1  - Krüger, Hans-Peter
T1  - What differentiates a differential psychopharmacology?
N2  - The methodological implications of a differential psychopharmacology are discussed. It is shown that the technique of stratifying subjects with personality scores depends on one basic assumption: the personality score is not affected by the other experimental factors. Two experiments are reported in which pre- and posttest (after the experiment) scores were measured. The pre-post-differences showed themselves to be affected by the medication. It is argued that in psychopharmacological experimentation an additional step must be included. All non-treatment factors must be examined for their stability in the course of the experiment. If they are stable, usual evaluation may take place. If changes are attributable to the treatment, personality scores must be regarded as dependent variables. They have to be evaluated together with the other observables with a multivariate model. Additionally, a procedure like this yields as "experimental differential psychology" a self-reliant contribution to the problems of differential psychology.
KW  - Differential psychopharmacology
KW  - differential psychology
KW  - drug-personality interaction
KW  - methodology of differential psychopharmacology
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41248
ER  - 
TY  - JOUR
A1  - Härtlein, Michael
A1  - Schiessl, Sigrid
A1  - Wagner, Wilma
A1  - Rdest, Ursula
A1  - Kreft, Jürgen
A1  - Goebel, Werner
T1  - Transport of hemolysin by Escherichia coli
N2  - No abstract available
KW  - Biologie
KW  - Hemolysin
KW  - Escberichia coli
KW  - Gene cloning
KW  - Expression
KW  - Transport
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-60619
ER  - 
TY  - JOUR
A1  - Hoppe, J.
A1  - Friedl, P.
A1  - Schairer, H. U.
A1  - Sebald, Walter
A1  - Meyenburg, K. von
A1  - Jorgensen, B. B.
T1  - The topology of the proton translocating F\(_0\) component of the ATP synthase from E. coli K12: studies with proteases
N2  - The accessibility of the three F\(_0\) subunits a, b and c from the Escherichia coli Kll A TP synthase to various proteases was studied in F\(_1\)-depleted inverted membrane vesicles. Subunit b was very sensitive to all applied proteases. Chymotrypsin produced a defined fragment of mol. wt. 1S 000 which remained tightly bound to the membrane. The cleavage site was located at the C-terminal region of subunit b. Larger amounts of proteases were necessary to attack subunit a (mol. wt. 30 000). There was no detectable deavage of subunit c. It is suggested that the major hydrophilic part of subunit b extends from the membrane into the cytoplasm and is in contact with the F\(_1\) sector. The F\(_1\) sector was found to afford some protection against proteolysis oftheb subunit in vitro andin vivo. Protease digestion bad no influence on the electro-impelled H\(^+\) conduction via F\(_0\) bot ATP-dependent H\(^+\) translocation could not be reconstituted upon binding of F\(_1\)• A possible role for subunit b as a linker between catalytic events on the F\(_1\) component and the proton pathway across the membrane is discussed.
KW  - Biochemie
KW  - protein pathway
KW  - ATPase mutants
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-62718
ER  - 
TY  - JOUR
A1  - Sagelsdorff, P.
A1  - Lutz, Werner K.
A1  - Schlatter, C.
T1  - The relevance of covalent binding to mouse liver DNA to the carcinogenic action of hexachlorocyclohexane isomers
N2  - [\(^3\)H]Hexachlorocyclohexane (HCH) was synthesized by chlorination of [\(^3\)H]benzene prepared by catalytic tritiation of benzene with tritiated water. The isomers of HCH were separated by adsorption chromatography on silica gel. In order to determine the covalent binding to DNA, [\(^3\)H]HCH was administered to male mice by oral gavage, and liver DNA was isolated via cbromatin. The specific radioactivity of the DNA was nonnalized by the dose administered and expressed in the molar units of the Covalent binding index, CBI = DNA damage/dose = (\(\mu\)mol bound HCH/mol DNA nucleotide)/(mmol HCH administered/kg body weight). CBI values of - 0.2 were found 10 h after the administration of alpha- and gamma-HCH. Enzymatic digestion of the DNA to the nucleosides and h.p.l.c. analysis revealed that - 40% of the radioactivity co-migrated with the natural nucleosides. At elution volumes known to contain the more lipophilic carcinogen-nucleoside adducts, - 10% of the radioactivity could be detected. The remaining 50% of th,e radioactivity eluted with the front, representing a mixture of oligonucleotide- HCH adducts and/or hydrophilic degradation products which were strongly bot not covalently associated with intact DNA. Therefore, a true CBI of 0.02-0.1 must be expected both for alpha- and gamma-HCH. This CBI is by a factor of 10\(^5\) -10\(^6\) below the value found with the strongest DNAbinding carcinogens like aflatoxin B1 or dimethylnitrosamine and is unlikely to be decisive for the liver tumor induction in mice because of the foUowing additional findings: (i) both isomers gave rise to similar Ievels of DNA darnage although the alpha-isomer is a much morepotent tumor inducer. This similarity was seen not only at the time of mäximum binding but up to 10 days after oral administration; (ii) three mouse strains with apparently different susceptibility to tumor induction by gamma-HCH could not be distinguished with respect to DNA binding; (iii) the level of DNA binding of alpha-HCH (CBI = 0.02-0.1) is more than three orders of magnitude lower than would be expected if the mechanism of tumor induction was by genotoxicity mediated by DNAbinding. For a preliminary investigation on a potential stimulatory effect on liver DN A replication and ceU division, [\(^{14}\)]thymidine was admlnistered i.p. 3.5 h before sacrifice of the [\(^3\)H]HCH-treated mice. The alpha-isomer was found to be more potent than the gamma-isomer in this respect. Taken together, our data allow the conclusion that the non- mutational processes must be more important for the carcinogenicity of HCH.
KW  - Toxikologie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61039
ER  - 
TY  - JOUR
A1  - Christl, Manfred
A1  - Leininger, Hartmut
A1  - Mattauch, Brigitte
T1  - The <sup>13</sup>C NMR Spectra of Some Tricyclo[2.2.0.0<sup>2,6</sup>]hexane Derivatives : Unexpected High Field Absorptions Due to Additive gamma-anti Subsituent Effects
N2  - By means of the BC NMR spectra of tricyclo{2.2.0~rfJ6Jhexane and thirteen of its derivatives the effects of substituents in endo-3- and endo-5-positions on the HC chemical shifts have been determined. The y-anti effects are at least as Jarge as in monosubstituted cyc1obutanes, where the shielding values of second-row hetero substituents exceed those in unstrained systems by far, and higher-row and carbon substituents still cause substantial upfield shifts. In the title system the y-anti effect of a substituent in the endo-3- and endo-5-position are operative additively, and thus shift the absorption of C-J upfieJd by a maximum of 27 ppm with respect to the unsubstituted hydrocarbon.
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-41620
SN  - x
ER  - 
TY  - JOUR
A1  - Hacker, Jörg
A1  - Knapp, S.
A1  - Goebel, W.
T1  - Spontaneous deletions and flanking regions of the chromosomal inherited hemolysin determinant of an Escherichia coli 06 strain
N2  - The hemolytic Escherichia coli strain 536 (06) propagates spontaneous hemolysin- negative mutants at relatively high rates (10-3 to 10-4 ). One type of mutant (type I) lacks both secreted (external) and periplasmic (internal) hemolysin activity (HlYex - IHlYin -) and in addition shows no mannose-resistant hemagglutination (Mrh -), whereas the other type (type II) is HlYex -IHIYin + and Mrh +. The genetic determinants for hemolysin production (hly) and for mannose-resistant hemagglutination (mrh) of this strain are located on the chromosome. Hybridization experiments with DNA probes specific for various parts of the hly determinant reveal that mutants of type I have lost the total hly determinant, whereas those of type 11 lack only part of the hlyB that is essential for transport of hemolysin across the outer membrane. Using a probe that contains the end sequence of the plasmid pHly152-encoded hly determinant (adjacent to hlyB), we determined that a related sequence flanks also the hlyB-distal end of the chromosomal hly determinant of E. coli 536. In addition several other similar or even identical sequences are found in the vicinity of the hlyC- and the hlyB-distal ends of both the chromosomal and the plasmid hly determinants.
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-40260
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Bentlage, Anke
A1  - Towart, Robertson
A1  - Möller, Eike
T1  - Sila-pharmaca, XXV. Sila-analogues of nifedipine-like dialkyl 2,6-dimethyl-4-aryl-1,4 dihydropyridine-3,5-dicarboxylates, III
N2  - IS neue C/Si-Analogenpaare (C-Verbindungen und sila- bzw. disila-substituierte Derivate), die sich strukturell vom Nifedipin ableiten, wurden synthetisiert. Diese und einige weitere C/Si-Paare wurden hinsichtlich ihrer physikochemischen und pharmakologischen Eigenschaften vergleichend untersucht. Mittels reversed-phase-Dünnschichtchromatographie wurde gezeigt, daß die Sila- bzw. Disila-Analoga lipophiler sind als die entsprechenden C-Verbindungen. Bezüglich der spasmolytischen in vitra-Aktivitäten zeigen die Si-Verbindungen in erster Näherung ähnliche Struktur-Wirkungs-Beziehungen wie ihre Carba-Analoga. Dagegen konnten hinsichtlich der ill vlva-Effekte (cardiovasculäre und antihypertensive Aktivität) in einigen Fällen große Unterschiede nachgewiesen werden.
N2  - 15 new C/Si-analogue pairs (C-compounds and sila- or disila-substituted derivatives, respectively), which are structurally related to nifedipine, have been synthesized. These and some further C/Si-pairs have been investigated comparatively with respect to their physicochemical and pharmacological properties. Using reversed-phase thin-layer chromatography it was shown that both the sila- and disila-analogues are more Iipophilic than the corresponding C-compounds. With respect to the in vitra spasmolytic potencies the Si-compounds show approximately similar structure-activity relationships to their carba-analogues. However, in some cases marked differences in in vivo effects (cardiovascular and antihypertensive activity) could be demonstrated.
KW  - Anorganische Chemie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-78357
ER  - 
TY  - CHAP
A1  - Wilhelm, Gernot
T1  - Reconstructing the phonology of dead languages
N2  - no Abstract available
KW  - Schreiben
KW  - Schrift
KW  - Sprache
KW  - Alphabetisierung
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-103601
ER  - 
TY  - JOUR
A1  - Heinsen, Helmut
A1  - Heinsen, Y. L.
T1  - Quantitative studies on regional differences in Purkinje cell dendritic spines and parallel fiber synaptic density
N2  - No abstact available
KW  - Medizin
KW  - Cerebellar cortex
KW  - Albino rats
KW  - Quantitative anatomy
KW  - Purkinje cells
KW  - Spines
KW  - Parallel fiber synapses
KW  - Regional differences
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59917
ER  - 
TY  - JOUR
A1  - Christl, Manfred
A1  - Leininger, Hartmut
A1  - Brückner, Dieter
T1  - On the Nature of the Bicyclo [3.2.1]octa-3,6-dien-2-yl Anion: A <sup>13</sup>C NMR spectroscopic study
N2  - No abstract available
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30060
ER  - 
TY  - JOUR
A1  - Viebrock, A
A1  - Perz, A
A1  - Sebald, Walter
T1  - Molecular cloning of middle-abundant mRNAs from Neurospora crassa
N2  - no abstract available
KW  - Neurospora crassa
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-82033
ER  - 
TY  - JOUR
A1  - Scheer, Ulrich
A1  - Lanfranchi, Gerolamo
A1  - Rose, Kathleen M.
A1  - Franke, Werner W.
A1  - Ringertz, Nils R.
T1  - Migration of rat RNA polymerase I into chick erythrocyte nuclei undergoing reactivation in chick-rat heterokaryons
N2  - Transcriptionally inactive chick erythrocyte nudei were reactivated by Sendai virusinduced fusion of erythrocytes with rat L6j1 myoblasts. We used antibodies to trace the appearance of a specific protein engaged in transcription of a defined dass of genes, those coding for rRNA, during reactivation. Using immunofluorescence microscopy, we found increasing amounts of rat RNA polymerase I to appear, during a certain period of time after fusion, in the reforming nudeoli of the chick nudei. Amounts of rat RNA polymerase I sufficient to be detected by immunofluorescence microscopy had accumulated in the newly developed chick nudeoli 72- 190 h after fusion was initiated. This time interval coincides with the time when chick rRNA synthesis can first be detected. The results raise the possibility that during these stages of the reactivation process chick rRNA genes are transcribed by heterologous RNA polymerase I moleeules of rat origin.
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33232
ER  - 
TY  - JOUR
A1  - Meier-Bratschi, A.
A1  - Lutz, Werner K.
A1  - Schlatter, C.
T1  - Methylation of liver DNA of rat and mouse by N-nitrosodimethylamine formed in vivo from dimethylamine and nitrite
N2  - The extent of formation of N-nitrosodimethylaminc {NDMA) in the stomachs of rats and mice after sirnultancous oral administration of [\(^{14}\)C]dimethylamine and potassium nitrite was determined by measuring the methylation of liver DNA. With doses of around 1 mg dimethylamine hydrochloride/ kg body weight and 50 mg potassium nitrite/kg body weight. 0,8 % of the amine was nitrosated on average. The individual fluctuations ranged from 0.2 to 1.30% in the rat and from 0.2 to 1.9% in the mouse. Simultaneous administration of 50 mg sodium ascorbate (vitamin Cl/kg body weight inhibited the nitrosation by ahout 80% while 50 mg \(\alpha\)-tocopherol acetate [Vitamin E)/kg body weight reduced the nitrosation by about a half. Assuming similar kinctics and conditions of nitrosation in rats and man. a comparison of the formation of NDMA in vivo from dietary dimethylamine and nitrite with the estimated human uptake of preformed N DMA revealed that in vitro formation in the stomach of man is probably negligible.
KW  - Toxikologie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61052
ER  - 
TY  - JOUR
A1  - Jauch, A.
A1  - Lutz, Werner K.
T1  - In vivo assay for somatic point mutations induced by genotoxic carcinogens: incorporation of [\(^{35}\)S]methionine into a rat liver cytochrome b\(_5\) normally lacking sulphur-containing amino acids
N2  - The trypsin fragments of rat liver microsomal cytochron1e b\(_5\) (Tb\(_5\)) lack both methionine (met) and cysteine (cys), i.e., the sulphur-containing antino acids. Tb\(_5\) should therefore contain no 358-radioactivity after isolation from animals treated wHh [\(^{35}\)S]met or [\(^{36}\)S]cys. If, however, the nucleic acids coding for this polypeptide have been damaged by a genotoxic carcinogen, a miscoding could result in an incorporation of met or cys into the polypeptide so that Tb\(_8\) could now be \(^{36}\)S-radiolabelled. Two experiments are descrihed. the first one where a toxic regimen of N -nitrosomorpholine (NNM) to rats resulted in a significant increase of \(^{35}\)S-radioactivity in the Tbs of liver microsomes, and a second experiment with a non-toxic regimen of N,N diethylnitrosamine (DENA), where no increase was observable.
KW  - Toxikologie
KW  - MammaJian mutagenicity test
KW  - Pointmutation
KW  - Protein coding
KW  - Cytochrome b5
KW  - Amino acid composition
KW  - Rat Iiver microsomes
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61047
ER  - 
TY  - JOUR
A1  - Kleinschmidt, Jürgen A.
A1  - Scheer, Ulrich
A1  - Dabauvalle, Marie-Christine
A1  - Bustin, Michael
A1  - Franke, Werner W.
T1  - High mobility group proteins of amphibian oocytes: a large storage pool of a soluble high mobility group-1-like protein and involvement in transcriptional events
N2  - No abstract available
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-33250
ER  - 
TY  - JOUR
A1  - Hughes, C.
A1  - Hacker, Jörg
A1  - Roberts, A.
A1  - Goebel, W
T1  - Hemolysin production as a virulence marker in symptomatic and asymptomatic urinary tract infections caused by Escherichia coli
N2  - Potential virulence, as defined by combined Ievels of adhesion to urinary epithelial cells, serum resistance, and mouse toxicity, was assessed for Escherichia coli strains causing symptomatic and asymptomatic urinary tract infections in relation to the carriage of hemolysin and other suspected virulence determinants. Hemolysin production (Hly), associated with certain 0 (04, 06, 018, and 075), K (5), and hemagglutination (VI and VII) antigenic types but not colicin V production (Cva), was evident in 83 and 60% ofisolates in groups possessing high potential virulence andin only 11 and 6% of those with low virulence. Strains of particular 0-types were not more virulent per se, but among the serotypes, specific combinations of virulence factors appeared decisive, e.g., 018 HAVI B/D/G Hly+ K5+t- and 018 HAIIIIIVBN Hly- Cva +t- Kl +t- strains were, respectively, of high and low potential virulence. Isolates with high potential virulence were found to a similar extent in symptomatic and asymptomatic infections.
KW  - Infektionsbiologie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59346
ER  - 
TY  - JOUR
A1  - Kreft, Jürgen
A1  - Burger, Klaus J.
A1  - Goebel, Werner
T1  - Expression of antibiotic resistance genes from Escherichia coli in Bacillus subtilis
N2  - Bifunctional recombinant plasmids were constructed, comprised of the E. coli vectors pBR322, pBR325 and pACYC184 and different plasmids from Gram-positive bacteria, e.g. pBSU161-1 of B. subtilis and pUB110 and pC221 of S. aureus. The beta-lactamase (bla) gene and the chloramphenicol acetyltransferase (cat) gene from the E. coli plasmids were not transcribed and therefore not expressed in B. subtilis. However, tetracycline resistance from the E. coli plasmids was expressed in B. subtilis. Transcription of the tetracycline resistance gene(s) started in B. subtilis at or near the original E. coli promoter, the sequence of which is almost identical with the sequence recognized by σ<sup>55</sup> of B. subtilis RNA polymerase.
KW  - Biologie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-60600
ER  - 
TY  - CHAP
A1  - Clarke, AH
A1  - Ellgring, Johann Heinrich
T1  - Computer-aided video
N2  - The recent developments in microprocessor electronics and time-code equipment have vastly improved the efficiency of working with video material so that through the combination of data processing and video recording equipment a substantial rationalization of both data acquisition procedures and functional control of the recording machines may be achieved. Such a system, in which video editing and time-code control equipment is interfaced to a process computer, has been developed for the analysis of human communicative behaviour. The system provides exact indexing of the recorded material, automatic search and edit routines for the videotape machines and synchronicity of registered data. In summary, it can be maintained that given a sound theoretical basis, modern video and computer technologies can substantially increase the efficiency and accuracy of behavioural observation and analysis.
KW  - Psychologie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-50332
ER  - 
TY  - JOUR
A1  - Kreft, Jürgen
A1  - Berger, Harald
A1  - Härtlein, Michael
A1  - Müller, Bodo
A1  - Weidinger, Gerhard
A1  - Goebel, Werner
T1  - Cloning and expression in Escherichia coli and Bacillus subtilis of the hemolysin (cereolysin) determinant from Bacillus cereus
N2  - From a cosmid gene bank of Bacillus cereus GP4 in Escherichia coli we isolated clones which, after several days of incubation, formed hemolysis zones on erythrocyte agar plates. These clones contained recombinant cosmids with B. cereus DNA insertions of varying lengths which shared some common restriction fragments. The smallest insertionwas recloned as aPstl fragment into pJKK3-1, a shuttle vector which repücates in Bacillus subtilis and E. coli. When this recombinant plasmid (pJKK3-1 hly-1) was transformed into E. coli, it caused hemolysis on erythrocyte agar plates, but in liquid assays no extemal or intemal hemolytic activity could be detected with the E. coli transformants. B. subtilis carrying the same plasmid exhibited hemolytic activity at Ievels comparable to those ofthe B. cereus donor strain. The hemolysin produced in B. subtilis seemed to be indistinguishable from cereolysin in its sensitivity to cholesterol, activation by dithiothreitol, and inactivation by antibodies raised against cereolysin. When the recombinant DNA carrying the cereolysin gene was used as a probe in hybridization experiments with chromosomal DNA from a streptolysin 0-producing strain of Streptococcus pyogenes or from üsteriolysin-producing strains of Usteria monoeytogenes, no positive hybridization signals were obtained. These data soggest that the genes for these three SH-activated cytolysins do not have extended sequence homology.
KW  - Biologie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-60596
ER  - 
TY  - JOUR
A1  - Hacker, Jörg
A1  - Hughes, C.
A1  - Hof, H.
A1  - Goebel, W.
T1  - Cloned hemolysin genes from Escherichia coli that cause urinary tract infection determine different levels of toxicity in mice
N2  - After intraperitoneal injection of mice with Escherichia coli strains isolated from patients with urinary tract infections, the mortality due to hemolytic (Hly+) and nonhemolytic (Hiy-) isolates was 77 and 40%, respectively. Deletion of the chromosomal hemolysin (h/y) determinant in an E. co/i 06:K15:H31 urinary tract infection strain led to a significant reduction in toxicity for mice, and its reintroduction on a recombinant plasmid partially restored the original toxicity. Although introduction of the cloned plasmid pHiy152-encoded hly determinant into the Hly- E. coli 06 mutant strain increased toxicity by only a marginal degree, transformation with the cloned chromosomal hly determinants from two E. coli strains of serotypes 018ac:K5:H- and 075:K95:H? resulted in markedly greater toxicity, even exceeding that of the original Hly+ E. coli 06 wild-type strain.
KW  - Infektionsbiologie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59330
ER  - 
TY  - JOUR
A1  - Neumann-Haefelin, D.
A1  - Rethwilm, Axel
A1  - Bauer, G.
A1  - Gudat, F.
A1  - zur Hausen, H.
T1  - Characterization of a foamy virus isolated from Cercopithecus aethiops lymphoblastoid cells
N2  - A virus derived from cells of a Iymphoblastoid line originating from the lymph node of a healthy African green monkey was characterized as a typical member of the foamy virus subgroup of rctroviridac by its morphological, physicochemical, biological and biochemical properties (reverse transcriptase actvity). Besides the usual host range of foamy viruses, the isolated strain revealed a remarkable T -lymphotropism, distinguishing it from the prototypes of foamy viruses previously isolated from African green monkeys. Two foamy virus infectious are demonstrated in human contacts of the African green monkey colony, with the animal barbauring the isolate.
KW  - Virologie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-61538
ER  - 
TY  - JOUR
A1  - Heinsen, Helmut
A1  - Heinsen, Y. L.
T1  - Cerebellar capillaries: qualitative and quantitative observations in young and senile rats
N2  - Ultrastructural changes including reduced electron density, reduction in polysemes and cisternae of rough endoplasmic reticulum occur in the cytoplasrn of endothelial cells and pericytes in the cerebellar cortex of senile virgin female Han: WIST-rats in cornparison to 3-month old virgin rats. Processes of pericytes cover less of the capillary surface in the cerebellar cortex of senile rats; moreover, arithmetic and harmonic mean thickness of the endothelium and relative volume of mitochondria in endothelial cells and pericytes are reduced, w hereas the luminal diameter of the capillaries, harmonic and arithmetic mean thickness of pericytes and their processes and of the basal laminae between endothelial cells and astrocytes (abbreviated BAL 1), pericytes and astrocytes (BAL 2) and endothelial cells and pericytes (BAL 3) increase. The increase in harmonic mean thickness of the basal laminae is statistically significant (α<=0.05) and compensates for a decrease in thickness of capillary endothelium. Consequently, the total barrier mass and thickness of cerebellar cortical capillaries in senile animals is higher than in young individuals.
KW  - Medizin
KW  - Capillaries
KW  - Blood-brain barrier
KW  - Quantitative anatomy
KW  - Cerebellar cortex
KW  - Senile rats
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-59924
ER  - 
TY  - CHAP
A1  - Ellgring, Johann Heinrich
A1  - Clarke, AH
A1  - Wagner, H.
T1  - A syntactic approach to the analysis of nonverbal behaviour
N2  - No abstract available
KW  - Psychologie
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-52403
ER  - 
TY  - JOUR
A1  - Lanzendörfer, Franz
A1  - Christl, Manfred
T1  - 3,4-Bismethylentricyclo[3.1.0.0<sup>2,6</sup>]hexan - Synthese und Diels-Alder-Addition an Tetracyanethylen
N2  - No abstract available
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-30263
ER  -