TY  - JOUR
A1  - Horvat, Sonja
A1  - Vogel, Patrick
A1  - Kampf, Thomas
A1  - Brandl, Andreas
A1  - Alshamsan, Aws
A1  - Alhadlaq, Hisham A.
A1  - Ahamed, Maqusood
A1  - Albrecht, Krystyna
A1  - Behr, Volker C.
A1  - Beilhack, Andreas
A1  - Groll, Jürgen
T1  - Crosslinked Coating Improves the Signal‐to‐Noise Ratio of Iron Oxide Nanoparticles in Magnetic Particle Imaging (MPI)
JF  - ChemNanoMat
N2  - Magnetic particle imaging is an emerging tomographic method used for evaluation of the spatial distribution of iron‐oxide nanoparticles. In this work, the effect of the polymer coating on the response of particles was studied. Particles with covalently crosslinked coating showed improved signal and image resolution.
KW  - crosslinked coating
KW  - imaging agents
KW  - magnetic properties
KW  - MPI
KW  - MPS
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-214718
VL  - 6
IS  - 5
SP  - 755
EP  - 758
ER  - 
TY  - JOUR
A1  - Brand, Jessica S.
A1  - Forster, Leonard
A1  - Böck, Thomas
A1  - Stahlhut, Philipp
A1  - Teßmar, Jörg
A1  - Groll, Jürgen
A1  - Albrecht, Krystyna
T1  - Covalently Cross-Linked Pig Gastric Mucin Hydrogels Prepared by Radical-Based Chain-Growth and Thiol-ene Mechanisms
JF  - Macromolecular Bioscience
N2  - Mucin, a high molecular mass hydrophilic glycoprotein, is the main component of mucus that coats every wet epithelium in animals. It is thus intrinsically biocompatible, and with its protein backbone and the o-glycosidic bound oligosaccharides, it contains a plethora of functional groups which can be used for further chemical modifications. Here, chain-growth and step-growth (thiol-ene) free-radical cross-linked hydrogels prepared from commercially available pig gastric mucin (PGM) are introduced and compared as cost-efficient and easily accessible alternative to the more broadly applied bovine submaxillary gland mucin. For this, PGM is functionalized with photoreactive acrylate groups or allyl ether moieties, respectively. Whereas homopolymerization of acrylate-functionalized polymers is performed, for thiol-ene cross-linking, the allyl-ether-functionalized PGM is cross-linked with thiol-functionalized hyaluronic acid. Morphology, mechanical properties, and cell compatibility of both kinds of PGM hydrogels are characterized and compared. Furthermore, the biocompatibility of these hydrogels can be evaluated in cell culture experiments.
KW  - click chemistry
KW  - photopolymerization
KW  - hydrogels
KW  - mucin
KW  - thiol-ene
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-318453
VL  - 22
IS  - 4
ER  -