TY  - JOUR
A1  - Boelch, Sebastian Philipp
A1  - Weissenberger, Manuel
A1  - Spohn, Frederik
A1  - Rudert, Maximilian
A1  - Luedemann, Martin
T1  - Insufficient sensitivity of joint aspiration during the two-stage exchange of the hip with spacers
JF  - Journal of Orthopedic Surgery and Research
N2  - Background:
Evaluation of infection persistence during the two-stage exchange of the hip is challenging. Joint aspiration before reconstruction is supposed to rule out infection persistence. Sensitivity and specificity of synovial fluid culture and synovial leucocyte count for detecting infection persistence during the two-stage exchange of the hip were evaluated.

Methods:
Ninety-two aspirations before planned joint reconstruction during the two-stage exchange with spacers of the hip were retrospectively analyzed.

Results:
The sensitivity and specificity of synovial fluid culture was 4.6 and 94.3%. The sensitivity and specificity of synovial leucocyte count at a cut-off value of 2000 cells/μl was 25.0 and 96.9%. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values were significantly higher before prosthesis removal and reconstruction or spacer exchange (p = 0.00; p = 0.013 and p = 0.039; p = 0.002) in the infection persistence group. Receiver operating characteristic area under the curve values before prosthesis removal and reconstruction or spacer exchange for ESR were lower (0.516 and 0.635) than for CRP (0.720 and 0.671).

Conclusions:
Synovial fluid culture and leucocyte count cannot rule out infection persistence during the two-stage exchange of the hip.
KW  - two-stage exchange
KW  - hip
KW  - periprosthetic infection
KW  - joint aspiration
KW  - spacer
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-175576
VL  - 13
IS  - 7
ER  - 
TY  - JOUR
A1  - von Hertzberg-Boelch, Sebastian Philipp
A1  - Luedemann, Martin
A1  - Rudert, Maximilian
A1  - Steinert, Andre F.
T1  - PMMA bone cement: antibiotic elution and mechanical properties in the context of clinical use
JF  - Biomedicines
N2  - This literature review discusses the use of antibiotic loaded polymethylmethacrylate bone cements in arthroplasty. The clinically relevant differences that have to be considered when antibiotic loaded bone cements (ALBC) are used either for long-term implant fixation or as spacers for the treatment of periprosthetic joint infections are outlined. In this context, in vitro findings for antibiotic elution and material properties are summarized and transferred to clinical use.
KW  - spacer
KW  - bone cement
KW  - PMMA
KW  - polymethylmethacrylate
KW  - periprosthetic infection
KW  - antibiotic elution
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-281708
SN  - 2227-9059
VL  - 10
IS  - 8
ER  -