TY  - JOUR
A1  - Winter, Anna
A1  - Schulz, Stefan M.
A1  - Schmitter, Marc
A1  - Brands, Roman C.
A1  - Straub, Anton
A1  - Kübler, Alexander
A1  - Borgmann, Anna
A1  - Hartmann, Stefan
T1  - Oral-health-related quality of life in patients with medication-related osteonecrosis of the jaw: a prospective clinical study
JF  - International Journal of Environmental Research and Public Health
N2  - Medication-related osteonecrosis of the jaw (MRONJ) represents an adverse side effect of antiresorptive and antiangiogenic medications. It is associated with impaired quality of life, oral health, and oral function and can be classified into various stages. The purpose of this prospective clinical study is to evaluate the impact of stages I and II MRONJ on oral-health-related quality of life (OHRQoL) and related parameters. Patients’ OHRQoL, satisfaction with life, oral discomfort, and oral health were assessed using the German version of the Oral Health Impact Profile (OHIP-G49), visual analog scales (VAS), and Satisfaction with Life Scale (SWLS) at baseline (T0), 10 days (T1), and 3 months after treatment (T2) in 36 patients. Data were analyzed using Kolmogorov–Smirnov test, two-way mixed ANOVAs, and follow-up Mann–Whitney U tests. The impact of treatment effects on the original seven OHIP domain structures and the recently introduced four-dimensional OHIP structure were evaluated using linear regression analysis. Thirty-six patients received surgical MRONJ treatment. Before treatment, patients’ perceived OHRQoL, oral discomfort, oral health, and satisfaction with life were negatively affected by MRONJ. Surgical treatment significantly improved OHRQoL and related parameters (all p ≤ 0.012). This improvement was greater in patients with higher impairment at T0. OHRQoL and oral restrictions were still impaired after treatment in patients who needed prosthetic treatment. The four-dimensional structure revealed valuable information beyond the standard seven OHIP domains. Increased awareness of MRONJ risks and an interdisciplinary treatment approach for MRONJ patients are needed.
KW  - oral-health-related quality of life
KW  - satisfaction with life
KW  - oral health
KW  - medication-related osteonecrosis of the jaw
KW  - treatment benefit
KW  - OHIP-49
KW  - SWLS
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-288141
SN  - 1660-4601
VL  - 19
IS  - 18
ER  - 
TY  - JOUR
A1  - Winter, Anna
A1  - Schulz, Stefan M.
A1  - Schmitter, Marc
A1  - Müller-Richter, Urs
A1  - Kübler, Alexander
A1  - Kasper, Sylvia
A1  - Hartmann, Stefan
T1  - Comprehensive geriatric assessment and quality of life aspects in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC)
JF  - Journal of Clinical Medicine
N2  - To define frailty in older cancer patients, the aim of this study was to assess the geriatric status and quality of life (QoL) aspects in patients suffering from recurrent/metastatic head and neck squamous cell carcinoma (r/m HNSCC) under palliative treatment. A comprehensive geriatric assessment (CGA) was performed on 21 r/m HNSCC patients at two defined assessments, and the QoL aspects and the impact of descriptive data were evaluated. The Kolmogorov–Smirnov test, Spearman’s rho correlation, and two-way mixed ANOVA were used for statistical analysis. All patients were found to be “frail”. Pain, fatigue, and the burden of illness were the highest-rated symptoms. Oral function and orofacial appearance were highly impaired. A significant impact of descriptive data on the CGA and QoL results was found (all p ≤ 0.05). Thus, the CGA results revealed high frailty, severe comorbidities, and high impairments in QoL aspects. The CGA and QoL results were negatively affected by the primary HNSCC treatment approach, the need for prosthetic treatment, and worse oral functional capacity. Therefore, frailty in r/m HNSCC patients seems to be multidimensional. The evaluation of the CGA and QoL aspects in r/m HNSCC patients can be recommended to detect special needs, organize aftercare, and improve the support for frail and vulnerable cancer patients to create a multidisciplinary treatment approach.
KW  - frailty
KW  - geriatric cancer patient
KW  - recurrent/metastatic head and neck squamous cell carcinoma
KW  - oral health-related quality of life
KW  - prosthetic rehabilitation
KW  - oral functional capacity
Y1  - 2023
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-363096
SN  - 2077-0383
VL  - 12
IS  - 17
ER  -