TY  - JOUR
A1  - Tacke, Reinhold
A1  - Pikies, J.
A1  - Linoh, H.
A1  - Rohr-Aehle, R.
A1  - Gönne, S.
T1  - Sila-Procyclidin: Eine neue Synthese sowie Untersuchungen zur peripheren und zentralen anticholinergen Wirkung
N2  - Sila-Procyclidin (1 b) sowie dessen Derivate 2b (Sila-Tribexyphenidyl), 3b und 4b (Sila-Cycrimin) wurden - ausgehend von Cl\(_3\)SiCH\(_2\)Cl - durch eine neue, sechsstufige Synthese mit einer Gesamtausbeute von 16 (lb), t9 (2b), 8 (3b) bzw. 7% (4b) dar· gestellt. - Vergleichende in-vivo-Untcrsuchungen (Maus, per-osApplikation) hinsichtlich der peripheren und zentralen auticholincrgen Wirkung haben gezeigt, daß die Silicium-Verbindung 1 b dem Kohlenstoff-Analogon Ia (Procyclidin) überlegen ist.
N2  - Starting with Cl\(_3\)SiCH\(_2\)Cl. sila-procycUdine (I b) as well as its derivatives 2b (sila-trihexyphenidyl), 3b, and 4b (sila-cycrimine) were prepared by a new six-step synthesis witb a total yield of 16 (lb), 19 (2b), 8 (31) aud 7% (4b), respectively. - Comparative in vivo investigations (mice per os administration) with respect to the peripheral and centrat anticholinergic activity bavc shown that the silicon compound 1 b is advantageous over the c:arbon aualogue t a (procyclidine).
KW  - Anorganische Chemie
Y1  - 1987
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63815
ER  - 
TY  - JOUR
A1  - Sarge, S.
A1  - Cammenga, H. K.
A1  - Becker, B.
A1  - Rohr-Aehle, R.
A1  - Tacke, Reinhold
T1  - Energetic and kinetic investigation of thermally induced molecular rearrangements of esters of (hydroxymethyl)hydridosilanes by DSC
N2  - No abstract available
KW  - Anorganische Chemie
Y1  - 1988
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63850
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Rohr-Aehle, R.
T1  - Ester des (Hydroxymethyl)[(trimethylsilyl)methyl]silans: Synthese und thermisch induzierte Umlagerung
N2  - Die Synthese des (Hydroxymethyl)[(trimethylsilyl)methyl]silans (3) sowie des hiervon abzuleitenden Acetats 4 und Chlorformiats 6 wird beschrieben. 4 und 6 unterliegen einer thermisch induzierten Umwandlung zu den difunktionellen Silanen 5 bzw. 8. Die Umwandlungen 4 -> 5 und 6 -> 8 erfolgen gemäß einer Kinetik 1. Ordnung mit Halbwertszeiten von 10.0 bzw. 3.6 h (135 ° C, in C\(_6\)D\(_6\)).
N2  - The synthesis of (hydroxymethyl)[(trimethylsilyl)methyl]silane (3) and that of the corresponding acetate 4 and chloroformiate 6 are described. 4 and 6 undergo a thermally induced rearrangement to give the difunctional silanes 5 and 8, respectively. The transformations 4 -> 5 and 6 -> 8 follow a first order rate law with half life times of 10.0 and 3.6 h, respectively (135 o C, in C\(_6\)D\(_6\) ).
KW  - Anorganische Chemie
Y1  - 1988
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-63889
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Wiesenberger, F.
A1  - Becker, B.
A1  - Rohr-Aehle, R.
A1  - Schneider, P. B.
A1  - Ulbrich, U.
A1  - Sarge, S. M.
A1  - Cammenga, H. K.
A1  - Koslowski, T.
A1  - Niessen, W. von
T1  - Ester von (Hydroxymethyl)diorganylsilanen: Synthese und thermisch induzierte Umlagerung
T1  - Esters of (Hydroxymethyl)diorganylsllanes: Synthesis and Thermally Induced Rearrangement
N2  - Twenty silanes of the type R\(^1\)R\(^2\)Si(H)CH\(_2\)OR\(^3\) (A) were syn- and entropy of activation) of these reactions were studied by thesized {R\(^1\), R\(^2\) = Me, Ph, 1-naphthyl, PhCH\(_2\), Me\(_3\)SiCH\(_2\); OR\(^3\) means of düferential scanning calorimetry (DSC). In addition, = OC(O)Me, OC(O)Ph, OC(O)CF\(_3\) , OS(0)\(_2\)CF\(_3\), OP(O)Ph\(_2\), the kinetics of all reactions were investigated by 1H-NMR OC(O)Cl, and studied for their thermal behaviour. The silanes spectroscopy. The transition state of the rearrangement was A undergo a thermally induced rearrangement to give the investigated by an ab initio study based on the model comcorresponding silanes R\(^1\)R\(^2\)Si(OR\(^3\))Me (B). For compounds with pound H\(_3\)SiCH\(_2\)OC(O)H (-> MeH\(_2\)SiOC(O)H]. The theoretical OR3 = OC(O)Cl, an additional decarboxylation takes place to data and the experimentally obtained energetic and kinetic yield the chlorosilanes R1R2Si(Cl)Me. Except for the deriva- data are discussed in terms of mechanistic aspects of the retives with OR\(^3\) = OC(O)Cl, the energetic (reaction enthalpy) arrangement reaction A -> B. and kinetic data (reaction order, frequency factor, enthalpy ...
KW  - Anorganische Chemie
Y1  - 1992
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-64188
ER  -