TY  - JOUR
A1  - Tacke, Reinhold
A1  - Kropfgans, Martin
A1  - Tafel, Andrea
A1  - Wiesenberger, Frank
A1  - Sheldrick, William S.
A1  - Mutschler, Ernst
A1  - Egerer, Hansjörg
A1  - Rettenmayr, Nikola
A1  - Gross, Jan
A1  - Waelbroeck, Magali
A1  - Lambrecht, Günter
T1  - (Hydroxymethyl)diphenyl(piperidinoalkyl)silane des Typs (HOCH2)(C6H5)2Si(CH2)nNC5H10 (n = 2,3) und deren Methoiodide: Synthese, Struktur und antimuscarinische Eigenschaften
N2  - No abstract available.
KW  - (Hydroxymethyl)diphenyl(piperidinoalkyl)silanes
KW  - Sila-pridinol
KW  - Sila-difenidol
KW  - muscarinic antagonists
KW  - muscarinic receptors
Y1  - 1994
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-86904
ER  - 
TY  - JOUR
A1  - Tacke, Reinhold
A1  - Lange, Hartwig
A1  - Sheldrick, William S.
A1  - Lambrecht, Günter
A1  - Moser, Ulrich
A1  - Mutschler, Ernst
T1  - Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon
T1  - Sila-Pharmaca, 31 th Communication [1] Synthesis, Structure, and Pharmacological Properties of Diphenyl(2-piperidinoethoxymethyl)silanol and its Carbon Analogue
JF  - Zeitschrift für Naturforschung B
N2  - In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).
KW  - antimuscarinic and papaverine-like activity
KW  - sila-substitution
KW  - crystal and molecular structure
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-128410
VL  - 38
IS  - 6
ER  -