TY  - JOUR
A1  - Eidmann, Annette
A1  - Ewald, Andrea
A1  - Boelch, Sebastian P.
A1  - Rudert, Maximilian
A1  - Holzapfel, Boris M.
A1  - Stratos, Ioannis
T1  - In vitro evaluation of antibacterial efficacy of vancomycin-loaded suture tapes and cerclage wires
JF  - Journal of Materials Science: Materials in Medicine
N2  - Usage of implants containing antibiotic agents has been a common strategy to prevent implant related infections in orthopedic surgery. Unfortunately, most implants with microbial repellent properties are characterized by accessibility limitations during daily clinical practice. Aim of this in vitro study was to investigate whether suture tapes and cerclage wires, which were treated with vancomycin, show a sustainable antibacterial activity. For this purpose, we used 24 stainless steel wire cerclages and 24 ultra-high molecular weight polyethylene and polyester suture tape test bodies. The test bodies were incubated for 30 min. in 100 mg/ml vancomycin solution or equivalent volumes of 0.9% NaCl. After measuring the initial solution uptake of the test bodies, antibacterial efficacy via agar diffusion test with Staphylococcus aureus and vancomycin elution tests were performed 1, 2, 3, and 6 days after incubation. Vancomycin-loaded tapes as well as vancomycin-loaded cerclage wires demonstrated increased bacterial growth inhibition when compared to NaCl-treated controls. Vancomycin-loaded tapes showed an additional twofold and eightfold increase of bacterial growth inhibition compared to vancomycin-loaded wires at day 1 and 2, respectively. Elution tests at day 1 revealed high levels of vancomycin concentration in vancomycin loaded tapes and wires. Additionally, the concentration in vancomycin loaded tapes was 14-fold higher when compared to vancomycin loaded wires. Incubating suture tapes and cerclage wires in vancomycin solution showed a good short-term antibacterial activity compared to controls. Considering the ease of vancomycin application on suture tapes or wires, our method could represent an attractive therapeutic strategy in biofilm prevention in orthopedic surgery.
KW  - anti-bacterial agents / administration & dosage
KW  - anti-bacterial agents / chemistry
KW  - bone wires
KW  - drug liberation
KW  - materials testing
KW  - anti-bacterial agents / pharmacology
KW  - biocompatible Materials
KW  - prostheses and implants
KW  - Staphylococcus aureus / drug effects
KW  - sutures
KW  - Vancomycin / administration & dosage
KW  - Vancomycin / chemistry
KW  - Vancomycin / pharmacology
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-260089
VL  - 32
IS  - 4
ER  -