TY  - JOUR
A1  - Kaiser, Mathias
A1  - Burek, Malgorzata
A1  - Britz, Stefan
A1  - Lankamp, Frauke
A1  - Ketelhut, Steffi
A1  - Kemper, Björn
A1  - Förster, Carola
A1  - Gorzelanny, Christian
A1  - Goycoolea, Francisco M.
T1  - The influence of capsaicin on the integrity of microvascular endothelial cell monolayers
JF  - International Journal of Molecular Sciences
N2  - Microvascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.
KW  - tight junctions
KW  - capsaicin
KW  - endothelial cells
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-284865
SN  - 1422-0067
VL  - 20
IS  - 1
ER  -