TY  - JOUR
A1  - Baune, Bernhard T.
A1  - Konrad, Carsten
A1  - Grotegerd, Dominik
A1  - Suslow, Thomas
A1  - Birosova, Eva
A1  - Ohrmann, Patricia
A1  - Bauer, Jochen
A1  - Arolt, Volker
A1  - Heindel, Walter
A1  - Domschke, Katharina
A1  - Schöning, Sonja
A1  - Rauch, Astrid V.
A1  - Uhlmann, Christina
A1  - Kugel, Harald
A1  - Dannlowski, Udo
T1  - Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain
JF  - Journal of Neuroinflammation
N2  - Background: Cytokines such as interleukin 6 (IL-6) have been implicated in dual functions in neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative and neuroproliferative properties of cytokine genes. In this study the potential dual role of several IL-6 polymorphisms in brain morphology is investigated. 
Methodology: In a large sample of healthy individuals (N = 303), associations between genetic variants of IL-6 (rs1800795; rs1800796, rs2069833, rs2069840) and brain volume (gray matter volume) were analyzed using voxel-based morphometry (VBM). Selection of single nucleotide polymorphisms (SNPs) followed a tagging SNP approach (e. g., Stampa algorigthm), yielding a capture 97.08% of the variation in the IL-6 gene using four tagging SNPs. Principal findings/results In a whole-brain analysis, the polymorphism rs1800795 (-174 C/G) showed a strong main effect of genotype (43 CC vs. 150 CG vs. 100 GG; x = 24, y = -10, z = -15; F(2,286) = 8.54, p(uncorrected) = 0.0002; p(AlphaSim-corrected) = 0.002; cluster size k = 577) within the right hippocampus head. Homozygous carriers of the G-allele had significantly larger hippocampus gray matter volumes compared to heterozygous subjects. None of the other investigated SNPs showed a significant association with grey matter volume in whole-brain analyses. 
Conclusions/significance: These findings suggest a possible neuroprotective role of the G-allele of the SNP rs1800795 on hippocampal volumes. Studies on the role of this SNP in psychiatric populations and especially in those with an affected hippocampus (e.g., by maltreatment, stress) are warranted.
KW  - aging brain
KW  - hippocampal neurogenesis
KW  - cholinergic neurons
KW  - neurothrophic factor
KW  - Alzheimers disease
KW  - neurite outgrowth
KW  - inflammatory cytokines
KW  - major depression
KW  - nervour system
KW  - dentate gyrus
KW  - genetics
KW  - inflammation
KW  - interleukin 6
KW  - neuroprotection
KW  - voxel-based morphometry
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-130804
VL  - 9
IS  - 125
ER  - 
TY  - JOUR
A1  - Song, Ning-Ning
A1  - Jia, Yun-Fang
A1  - Zhang, Lei
A1  - Zhang, Qiong
A1  - Huang, Ying
A1  - Liu, Xiao-Zhen
A1  - Hu, Ling
A1  - Lan, Wei
A1  - Chen, Ling
A1  - Lesch, Klaus-Peter
A1  - Chen, Xiaoyan
A1  - Xu, Lin
A1  - Ding, Yu-Qiang
T1  - Reducing central serotonin in adulthood promotes hippocampal neurogenesis
JF  - Scientific Reports
N2  - Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We used tamoxifen (TM)-induced Cre in Pet1-CreER\(^{T2}\) mice to either deplete central serotonergic (5-HTergic) neurons or inactivate 5-HT synthesis in adulthood and explore the role of central 5-HT in adult hippocampal neurogenesis. A dramatic increase in hippocampal neurogenesis is present in these two central 5-HT-deficient mice and it is largely prevented by administration of agonist for 5-HTR2c receptor. In addition, the survival of new-born neurons in the hippocampus is enhanced. Furthermore, the adult 5-HT-deficient mice showed reduced depression-like behaviors but enhanced contextual fear memory. These findings demonstrate that lowering central 5-HT function in adulthood can also enhance adult hippocampal neurogenesis, thus revealing a new aspect of central 5-HT in regulating adult neurogenesis.
KW  - serotonin
KW  - SSRI
KW  - hippocampal neurogenesis
KW  - adulthood
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:20-opus-168004
VL  - 6
IS  - 20338
ER  -